Macroamylasemia in a 4-year-old girl with abdominal pain

Ko, Jeong Hee; Lee, Dae Hyoung

doi:10.3345/kjp.2009.52.11.1283

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…It has been associated with various diseases such as celiac disease, lymphoma, the human immunodeficiency virus infection, monoclonal gammopathy, rheumatoid arthritis, and ulcerative colitis. The exact prevalence of macroamylasemia in children remains unknown, and there have only been a few reports on pediatric cases with celiac disease [5], lymphoma in Wiskott-Aldrich syndrome [6], Crohn disease [7], and appendicitis [8]. In the present case, a severely multiple-handicapped boy had a significantly elevated plasma amylase level while in the hospital for acute asthmatic bronchitis.…”

Section: Introductionmentioning

confidence: 54%

Transient Macroamylasemia in a Severely Multiple-Handicapped Child Following the Development of Acute Bronchitis

Sakurai

2015

OJPed

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Macroamylasemia is a condition of elevated serum amylase levels in which normal serum amylase form a complex with high molecular weight proteins such as immunoglobulins. This is a case report on a patient with macroamylasemia following acute asthmatic bronchitis. A 5-year-old male with cerebral palsy and developmental retardation was admitted to our hospital because of high fever and severe cough. Treatment of the respiratory symptoms provided symptomatic improvement, but the serum amylase levels became suddenly elevated. Although acute pancreatitis associated with respiratory infection was initially suspected, a predominant salivary isoamylase, normal serum lipase level, low urine amylase level, and low amylase-creatinine clearance ratio (ACCR) (0.58%) indicated macroamylasemia. The serum amylase level decreased, and the ACCR increased within normal range 2 weeks after discharge. Both of these indicators have been within normal range over the past year. Transient macroamylasemia can be misdiagnosed as acute pancreatitis, especially in a severely multiple-handicapped child who is unable to complain. The ACCR is useful in the diagnosis of macroamylasemia.

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Section: Introductionmentioning

confidence: 54%

Transient Macroamylasemia in a Severely Multiple-Handicapped Child Following the Development of Acute Bronchitis

Sakurai

2015

OJPed

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“…Strangely, this disorder has no symptoms. 16 It's primarily identified by the presence of too much amylase in the blood. Unfortunately, this characteristic is synonymous to that of acute pancreatitis, which is also characterized by high levels of amylase in the blood.…”

Section: Macroamylasemiamentioning

confidence: 99%

“…In every situation, it's very important to identify the real cause of the high level of amylase in the blood, as any misdiagnosis of macroamylase, can lead to costly analyses for ruling out pancreatic disease and unnecessary prescriptions such as fasting and intravenous replacement therapies. 16 Macroamylasemia can be differentiated from acute pancreatitis through analysis of the urine level of amylase. Generally, the urine levels of amylase are low in people with macroamylasemia but high in patients with acute pancreatitis.…”

Section: Macroamylasemiamentioning

confidence: 99%