Macrocyclic supramolecular biomaterials in anti-cancer therapeutics

Hazarika, Biki; Singh, Ved Prakash

doi:10.1016/j.cclet.2023.108220

Cited by 15 publications

(3 citation statements)

References 161 publications

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“…130 Nowadays CB[ n ]s have taken over the prominent spot of highly promising macrocyclic candidates for biological applications and drug delivery. 98,122,125,131–151 Moreover, CB[ n ] hosts have shown potential as supramolecular antidotes, neutralizing the effects of a poison though the encapsulation of a small toxic molecule. 147,152,153 The so-called chemical reasons for these new trends are the observations that CDs, when compared to CB[ n ]s, show generally lower selectivity and weaker binding affinities 52 ( K a are usually lower than 10 5 M −1 ).…”

Section: Cucurbit[n]urils In Drug Deliverymentioning

confidence: 99%

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

Alešković,

Šekutor

2024

RSC Med. Chem.

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Section: Cucurbit[n]urils In Drug Deliverymentioning

confidence: 99%

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

Alešković,

Šekutor

2024

RSC Med. Chem.

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“…Currently, the varied biological features of the metal complexes of Schiff base macrocycles (including the -C=N group) attract a lot of interest as shown in Figure 1. [10][11][12][13][14][15][16]…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes

Mishra,

Sethi,

Ramasamy

et al. 2024

Eur J Clin Exp Med

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Introduction and aim. At present, several microbial diseases are prominent and of concern worldwide. The intent of this study was to examine the antibacterial potential of newly synthesized tetradentate macrocyclic complexes against different bacte rial strains. The macrocyclic scaffold has gained attention as a biologically active class of supramolecular chemistry due to its unique properties and ability to target various microorganisms. Thus, the goal of the present study was to develop a series of biologically active transition metal-based macrocycles. Material and methods. All macrocyclic compounds were synthesized by a template method and validated by molar conductiv ity, elemental studies, and spectral and magnetic studies. Antibacterial activities of all metal complexes were evaluated against Escherichia coli (MTCC 739) and Staphylococcus aureus (MTCC 731) bacterial strains by taking ampicillin as a standard reference drug. DNA photocleavage potential was explored using agarose gel electrophoresis. Results. Results revealed the formation of novel macrocyclic complexes via tetra nitrogen bond trapping of metals. Copper complexes have strong potential against S. aureus bacteria as copper and nickel both show good DNA photocleavage potential. Conclusion. The findings endorse the biomedical relevance of these macrocyclic scaffolds, suggesting avenues for further exploration in targeted drug delivery and potential clinical applications. The proposed octahedral geometry for the complexes enhances our understanding of their structural aspects. This research contributes substantively to the field, laying the foundation for future investigations in advanced antimicrobial design and application.

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“…Macrocyclic hosts, including crown ethers [9,10], cyclodextrins [11][12][13][14][15], calixarenes [16], cucurbiturils [17][18][19], pillararenes [20][21][22][23][24][25][26], coronarenes [27] and oxatubarenes [28], are attractive supramolecular hosts with inherent cavities. Thanks to their excellent host-guest properties, macrocyclic hosts play important roles in the fields of chemistry [29][30][31][32], materials science [33][34][35][36], biology [37][38][39][40][41], etc.…”

Section: Introductionmentioning

confidence: 99%

Biphenarenes, Versatile Synthetic Macrocycles for Supramolecular Chemistry

2023

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The development of supramolecular chemistry has always been accompanied by the innovation of macrocyclic hosts. The synthesis of novel macrocycles with unique structures and functions will bring new development opportunities for supramolecular chemistry. As a new generation of macrocyclic hosts, biphenarenes have customizable cavity sizes and diverse backbones, overcoming the limitation that the cavities of traditionally popular macrocyclic hosts are generally smaller than 10 Å. These features undoubtedly endow biphenarenes with distinguished host–guest properties, which have attracted more and more attention. In this review, the structural characteristics and molecular recognition properties of biphenarenes are summarized. In addition, the applications of biphenarenes in adsorption and separation, drug delivery, fluorescence sensing and other fields are introduced. Hopefully, this review will provide a reference for the study of macrocyclic arenes, especially biphenarenes.

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Macrocyclic supramolecular biomaterials in anti-cancer therapeutics

Cited by 15 publications

References 161 publications

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes

Biphenarenes, Versatile Synthetic Macrocycles for Supramolecular Chemistry

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