Macrocyclic “tet a” derived colorimetric sensor for the detection of mercury cations and hydrogen sulphate anions and its bio-imaging in living cells

Optical sensing of anions by macrocyclic and interlocked hosts

“…In contrast, the binding of HSO 4 − in the same solvent mixture, which was postulated to occur via multiple hydrogen bonds and/or charged interactions with the amine and hydroxyl groups of 38, induced chelation-enhanced fluorescence by restricting the free rotation of the sensor. 67 Ionisable pyridine groups have also been used to enhanced the binding of receptors to anions. Johnson and co-workers reported two pyridine-containing macrocycles 39a-b (Fig.…”

Fluorescence-Based Sensing of Pesticides Using Supramolecular Chemistry

“…Of note, one clear advantage to the use of fluorescent macrocycles is the fact that signaling elements are built right into the structure of the macrocycle, which provides close contact between that element and the pesticide analyte that binds in the macrocycle cavity (Jiang et al, 2020c). Although the potential for such close contacts to lead to improved sensor performance exists, in many cases the sensitivity and selectivity obtained from using fluorescent macrocycle sensors are essentially indistinguishable from those obtained using other macrocycle scaffolds (Sethupathi et al, 2020). Additional advantages of such macrocycles include the ability to attach them to solid supports, including paper (Kumar et al, 2018) and glass backing (Wienke et al, 1996), for the development of solid-state sensors (Lvova et al, 2018).…”

Mercury Toxicity and Detection Using Chromo-Fluorogenic Chemosensors

“…The Hg 2+ sensing ability of 6 was further studied in live U-2-OS cells [37]. Murugan et al [38] have reported the tetraazamacrocyclic derivative appended with the salicylaldehyde 7 (Figure 5) for the selective fluorescent turn-off sensing of Hg 2+ in CH 3 CN/HEPES buffer (2:8, v/v). The fluorescence emission of 7 at 490 nm was quenched upon complexation with Hg 2+ in 1:1 ratio due to chelation enhancement quenching (CHEQ) effect.…”