Macrogeographic genetic structure of Lutzomyia longipalpis complex populations using Next Generation Sequencing

Casaril, Aline Etelvina; Alonso, Diego Peres; Franco, Karina Garcia; Alvarez, Marcus Vinícius Niz; Barrios, Suellem Petilim Gomes; Fernandes, Wagner de Souza; Infran, Jucelei de Oliveira Moura; Rodrigues, Ana Caroline Moura; Ribolla, Paulo Eduardo Martins; Oliveira, Alessandra Gutierrez de

doi:10.1371/journal.pone.0223277

Cited by 13 publications

(4 citation statements)

References 59 publications

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“…longipalpis in Brazil has been recently explored by Casaril et al, who demonstrated the occurrence of three Lu. longipalpis populations in endemic municipalities [51]. Such processes of divergence and speciation of vectors represent mechanisms generating the heterogeneity of vector capacity and competence, as well as vector susceptibility to infectious agents or insecticides.…”

Section: Inferences On the Transmission Dynamics Of Neotropical L Inmentioning

confidence: 99%

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

Boité

Späth

Bussotti

et al. 2019

Genes

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Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasite’s successful establishment on the continent.

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Section: Inferences On the Transmission Dynamics Of Neotropical L Inmentioning

confidence: 99%

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

Boité

Späth

Bussotti

et al. 2019

Genes

View full text Add to dashboard Cite

show abstract

“…al., who demonstrated the occurrence of three Lu. longipalpis populations in endemic municipalities [51]. Such processes of divergence and speciation of vectors represent mechanisms generating the heterogeneity of vector capacity and competence, as well as vector susceptibility to infectious agents or insecticides.…”

Section: Inferences On the Transmission Dynamics Of Neotropical L Inmentioning

confidence: 99%

Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania Infantum in the Americas

Boité¹,

Späth²,

Bussotti³

et al. 2019

Preprint

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Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of VL in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasites' successful establishment on the continent.

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“…However, two main obstacles prevented the generalization of these findings: (a) the genetic polymorphism of the Lu. longipalpis complex, with ongoing cryptic speciation processes and introgression between sibling species, with different vector capacity or spread potential (Casaril et al 2019); and (b) the plasticity that allows Lu. longipalpis dispersion and adaptation to different environments, probably caused by the aforementioned genetic heterogeneity, that consequently made different variables critical in different scenarios with disparate or even contradictory results (Lainson & Rangel 2005).…”

Section: Introductionmentioning

confidence: 99%

Lutzomyia longipalpis, Gone with the Wind and Other Variables

Salomón

2020

Neotrop Entomol

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Lutzomyia longipalpis (Lutz & Neiva) is the main vector of Leishmania infantum (Nicolle) in America, associated in turn with the current spread and urbanization of American visceral leishmaniasis (AVL). The vector distribution in AVL foci shows a spatial-temporal clustering despite the different epidemiological contexts. The factors associated with the macroscale distribution of Lu. longipalpis as a landscape stratification are discussed in the framework of the process of their adaptation to anthropized environments. On the other hand, the fact that Lu. longipalpis is clustered in only a few hot spots or critical sites suggests that microscale approaches that describe the trap surrounding environment and the availability of refuges and food sources are better at explaining the uneven distribution of this vector, and should contribute, together with macroscale variables, to design operational control strategies. With regard to temporal distribution and climatic or vegetation data obtained by remote sensing as variables to explain and forecast the abundance of Lu. longipalpis, it is necessary to take into account the time lags in relation to the life cycle of the vector, the difference between the level of daily activity and actual abundance, and the differences in critical variables and thresholds according to the region or season. In conclusion, this review shows that it is feasible to characterize the distribution of Lu. longipalpis at focus level and within it to identify the main critical sites, proposing a sequential cost-effectivity strategy for urban AVL surveillance and control.

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Macrogeographic genetic structure of Lutzomyia longipalpis complex populations using Next Generation Sequencing

Cited by 13 publications

References 59 publications

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania Infantum in the Americas

Lutzomyia longipalpis, Gone with the Wind and Other Variables

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