Macromol. Biosci. 4/2018

Vankayala, Raviraj; Corber, Samantha R.; Mac, Jenny T.; Rao, Masaru P.; Shafie, Mohammad; Anvari, Bahman

doi:10.1002/mabi.201870009

Cited by 6 publications

(10 citation statements)

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“…[210,211] Besides, it was proved that the system of EM-NVs-ICG was also suitable for imaging of ischemic stroke. [212] Liu. et al have synthesized a core-shell zinc gallogermanate nanostructuresmesoporous SiO 2 and further enveloped by EM-NVs.…”

Section: Biological Sensor and Diagnosticsmentioning

confidence: 99%

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Erythrocyte‐Inspired Functional Materials for Biomedical Applications

et al. 2022

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Erythrocytes are the most abundant cells in the blood. As the results of long‐term natural selection, their specific biconcave discoid morphology and cellular composition are responsible for gaining excellent biological performance. Inspired by the intrinsic features of erythrocytes, various artificial biomaterials emerge and find broad prospects in biomedical applications such as therapeutic delivery, bioimaging, and tissue engineering. Here, a comprehensive review from the fabrication to the applications of erythrocyte‐inspired functional materials is given. After summarizing the biomaterials mimicking the biological functions of erythrocytes, the synthesis strategies of particles with erythrocyte‐inspired morphologies are presented. The emphasis is on practical biomedical applications of these bioinspired functional materials. The perspectives for the future possibilities of the advanced erythrocyte‐inspired biomaterials are also discussed. It is hoped that the summary of existing studies can inspire researchers to develop novel biomaterials; thus, accelerating the progress of these biomaterials toward clinical biomedical applications.

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Section: Biological Sensor and Diagnosticsmentioning

confidence: 99%

“…[ 210,211 ] Besides, it was proved that the system of EM‐NVs‐ICG was also suitable for imaging of ischemic stroke. [ 212 ] Liu. et al.…”

Section: Biomedical Applications Of Erythrocyte‐inspired Materialsmentioning

confidence: 99%

Erythrocyte‐Inspired Functional Materials for Biomedical Applications

et al. 2022

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“…Vankayala designed a multifunctional nanoplatform with imaging detection and therapeutic thrombosist (Figure 3F, tPAconjugated NETs). [46] An NIR imaging agent ICG was loaded into nanoscale erythrocyte membranes and then combined with tissue fibrinogen activator tPA for the construction of the probe. tPA, is the only existing Food and Drug Administrationapproved pharmacologic treatment for ischemic stroke, and is a naturally occurring enzyme that catalyzes the conversion of plasminogen to plasmin when bound to fibrin in blood clots, resulting in dissolution of clots.…”

Section: Fibrin-targeting and Fibrinogen-targetingmentioning

confidence: 99%

“…Vankayala designed a multifunctional nanoplatform with imaging detection and therapeutic thrombosist (Figure 3F, tPA‐conjugated NETs) [46] . An NIR imaging agent ICG was loaded into nanoscale erythrocyte membranes and then combined with tissue fibrinogen activator tPA for the construction of the probe.…”

Section: Thrombus Probe For Fluorescence Imagingmentioning

confidence: 99%

Application of Near‐Infrared Fluorescence Imaging in Thrombosis Detection

Zhang

Wang

et al. 2022

Analysis & Sensing

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In recent years, researchers have developed a variety of near infrared (NIR) fluorescent probes to achieve visual detection of thrombotic plaques in vivo. In this review, after clarifying the advantages of NIR probes in sensing thrombus in vivo, the structures and design strategies underlying always-on and turnon NIR thrombus probes are discussed. Subsequently, by summarizing and classifying the biomarkers overexpressed in thrombus, we highlight the recent advances in thrombus NIR fluorescent probes in biomedical applications. Furthermore, specific issues and opportunities in this field are explored at the end of the review, which will facilitate the inventive design of new multifunctional fluorescent probes and actively promote their future clinical translation.

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“…In another example, RBC membranes were loaded with indocyanine green, a near-infrared imaging agent, as well as tPA for dissolving clots through the conversion of plasminogen to plasmin. 191 Here, the cell membrane acted to prolong the circulation of the formulation through immunomodulatory markers on the surface, while the tPA targeted clots via favorable fibrin binding. In vitro blood clot localization studies demonstrated significantly higher accumulation of the tPA-conjugated formulation when compared to unconjugated formulations, suggesting future utility of the platform for ischemic stroke applications.…”

Section: Diagnosticsmentioning

confidence: 99%