Macromol. Mater. Eng. 1/2013

Sakai, Reika; John, Baiju; Okamoto, Masami; Seppälä, Jukka; Vaithilingam, Jayasheelan; Hussein, Husnah; Goodridge, Ruth

doi:10.1002/mame.201370001

Cited by 9 publications

(13 citation statements)

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“…A high porosity and an adequate pore size are also necessary to allow for cell seeding and diffusion of nutrients . Moreover, biodegradability is an essential factor and it's also important to control the rate of degradation, allowing degradation to occur as neotissue forms …”

Section: Introductionmentioning

confidence: 99%

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Liu

Shen

et al. 2017

Macro Materials & Eng

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Biodegradable hydrogels have attracted much attention in tissue engineering due to their good biocompatibility and elastomeric behavior. In this work, a series of inorganic–organic polyhedral oligomeric silsequioxanes–poly(ethylene glycol) (POSS–PEG) hybrid hydrogels are prepared by covalently grafting POSS into PEG and further cross‐linked by matrix metalloproteinase (MMP) degradable peptide via Michael‐type addition polymerization. All the POSS–PEG hybrid hydrogels have a porous structure and high hydrophilic ability, and the grafted hydrophobic POSS macromers result in a higher mechanical properties and lower equilibrium swelling ratio. Additionally, the hydrogels can be biodegraded by MMP‐2 solution and the POSS loading level can influence the degradation rate. It is worth mentioning that POSS‐containing hybrid hydrogels can be prepared in water and be used for 3D cell culture. In vitro cell viability study on human umbilical vein endothelial cells for 3D cell culture indicates POSS–PEG hydrogels have good compatibility. All of these results suggest that these POSS–PEG hybrid hydrogels exhibit the potential for tissue engineering scaffolds.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Liu

Shen

et al. 2017

Macro Materials & Eng

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“…[7] A wide variety of solution phase fabrication methods exist, including those involving phase separation mechanisms [8,9] and templating. [10,11] Increasingly, fabrication processes are moving toward solventless methods in order to lessen the environmental and economic impact associated with the use of organic solvents. [12][13][14] The initiated chemical vapor deposition (iCVD) technique is an example of a solventless method that can be used to deposit thin dense polymer coatings by using gaseous monomer and initiator precursors.…”

Section: Introductionmentioning

confidence: 99%

All‐Dry Fabrication of Poly(methacrylic acid)‐Based Membranes with Controlled Dissolution Behavior

Seidel

Cheong

Kwong

et al. 2015

Macro Materials & Eng

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The all-dry fabrication of porous poly(methacrylic acid)-based membranes displaying tunable dissolution behaviors in aqueous media is presented. Poly(methacrylic acid) (PMAA) membranes were fabricated using a low temperature, solventless technique with gaseous initiator and monomer precursors. The PMAA was then converted to poly(methacrylic acid-co-methacrylic anhydride) by thermal annealing. By controlling the annealing time, the methacrylic anhydride (MAN) content was varied, which allowed for the dissolution behavior to be tuned. The incorporation of MAN moieties in the membranes also allowed for crosslinking via a vapor phase reaction with 1,3-diaminopropane. The membranes can be deposited on a variety of substrates, including gauze.

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“…Pore size and pore interconnectivity has considerable biological importance for bony ingrowths. Minimum pore size of 30–100 μm is required for cell migration, vascularization and transportation processes . Pores having a diameter greater than 50 µm are reported for positive impact on osteogenic outcomes while pores with diameter greater than 10 µm contribute to a higher bone inducing protein adsorption, ion exchange and bone‐like apatite formation .…”

Section: Resultsmentioning

confidence: 99%

Supercritical CO₂ deposition and foaming process for fabrication of biopolyester–ZnO bone scaffolds

Ivanović

Rezwan

Kroll

2017

J of Applied Polymer Sci

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Subsequent supercritical CO2‐assisted deposition and foaming process followed by in situ synthesis was used to fabricate functional polylactide (PLA) and polylactide–poly(ɛ‐caprolactone) (PLA–PCL) bone scaffolds. Deposition of zinc bis(2‐thenoyltrifluoroacetonate) as a ZnO precursor onto biopolyester substrates (30 MPa; 110 °C) was followed by fast depressurization to create cellular structure. Contact time was optimized regarding the deposition yield (2 h), while PCL content in PLA was varied (1–10 wt %). Scaffolds impregnated with the precursor were treated with hydrazine alcoholic solution to obtain biopolyester–ZnO composites. Precursor synthesis and deposition onto the scaffolds was confirmed by Fourier‐transform infrared. Processed scaffolds had micron‐sized pores (d50 ∼ 20 μm). High open porosity (69–77%) and compressive strength values (2.8–8.3 MPa) corresponded to those reported for trabecular bone. PLA blending with PCL positively affected precursor deposition, crystallization rate, and compressive strength of the scaffolds. It also improved PLA surface roughness and wettability which are relevant for cell adhesion. ZnO improved compressive strength of the PLA scaffolds without significant effect on thermal stability. Analysis of structural, thermal, and mechanical properties of biopolyester–ZnO scaffolds testified a great potential of the obtained platforms as bone scaffolds. Proposed processing route is straightforward and ecofriendly, fast, easy to control, and suitable for processing of thermosensitive polymers. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45824.

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Macromol. Mater. Eng. 1/2013

Cited by 9 publications

References 0 publications

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

All‐Dry Fabrication of Poly(methacrylic acid)‐Based Membranes with Controlled Dissolution Behavior

Supercritical CO₂ deposition and foaming process for fabrication of biopolyester–ZnO bone scaffolds

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Macromol. Mater. Eng. 1/2013

Cited by 9 publications

References 0 publications

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

All‐Dry Fabrication of Poly(methacrylic acid)‐Based Membranes with Controlled Dissolution Behavior

Supercritical CO2 deposition and foaming process for fabrication of biopolyester–ZnO bone scaffolds

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Supercritical CO₂ deposition and foaming process for fabrication of biopolyester–ZnO bone scaffolds