Macromolecular crowding in equine bone marrow mesenchymal stromal cell cultures using single and double hyaluronic acid macromolecules

Garnica-Galvez, Sergio; Skoufos, Ioannis; Tzora, Athina; Diakakis, Nikolaos; Prassinos, Nikitas; Zeugolis, Dimitrios I.

doi:10.1016/j.actbio.2023.08.042

Cited by 4 publications

(1 citation statement)

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“…In addition, HA increased the molecular polarity of the scaffold complex because of its hydroxyl, amine, and carboxyl groups. Garnica-Galvez [ 176 ] evaluates the physicochemical properties and biological consequences of mesenchymal stromal cell cultures of single and mixed HA molecules. It was found that in HA in type III collagen deposition was more pronounced and induced a higher degree of mineralization that enhanced chondrogenesis and osteogenesis.…”

Section: Applications Of Ha Bioinksmentioning

confidence: 99%

3D printed scaffolds based on hyaluronic acid bioinks for tissue engineering: a review

Chen,

Xue,

Zeng

et al. 2023

Biomater Res

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Hyaluronic acid (HA) is widely distributed in human connective tissue, and its unique biological and physicochemical properties and ability to facilitate biological structure repair make it a promising candidate for three-dimensional (3D) bioprinting in the field of tissue regeneration and biomedical engineering. Moreover, HA is an ideal raw material for bioinks in tissue engineering because of its histocompatibility, non-immunogenicity, biodegradability, anti-inflammatory properties, anti-angiogenic properties, and modifiability. Tissue engineering is a multidisciplinary field focusing on in vitro reconstructions of mammalian tissues, such as cartilage tissue engineering, neural tissue engineering, skin tissue engineering, and other areas that require further clinical applications. In this review, we first describe the modification methods, cross-linking methods, and bioprinting strategies for HA and its derivatives as bioinks and then critically discuss the strengths, shortcomings, and feasibility of each method. Subsequently, we reviewed the practical clinical applications and outcomes of HA bioink in 3D bioprinting. Finally, we describe the challenges and opportunities in the development of HA bioink to provide further research references and insights. Graphical Abstract

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Section: Applications Of Ha Bioinksmentioning

confidence: 99%