2019
DOI: 10.1101/667816
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Macromolecule Translocation in a Nanopore: Center of Mass Drift–Diffusion over an Entropic Barrier

Abstract: Many fundamental biological processes involve moving macromolecules across membranes, through nanopores, in a process called translocation. Such motion is necessary for gene expression and regulation, tissue formation, and viral infection. Furthermore, in recent years nanopore technologies have been developed for single molecule detection of biological and synthetic macromolecules, which have been most notably employed in next generation DNA sequencing devices. Many successful theories have been established, w… Show more

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Cited by 2 publications
(1 citation statement)
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“…The molecular mechanism for the increased retention time is unclear. Speculation on the mechanism has suggested increased interaction strength between the polymer and the pore (47,48), decreased solubility of the polymer as the solvent stops behaving as a good solvent (25), or changes in the entropic barrier to transport (49)(50)(51)(52). The temperature-dependent studies here shed light on the mechanism.…”
Section: Ionic Strength Dependence For Homopolymer Peg: Open Porementioning
confidence: 75%
“…The molecular mechanism for the increased retention time is unclear. Speculation on the mechanism has suggested increased interaction strength between the polymer and the pore (47,48), decreased solubility of the polymer as the solvent stops behaving as a good solvent (25), or changes in the entropic barrier to transport (49)(50)(51)(52). The temperature-dependent studies here shed light on the mechanism.…”
Section: Ionic Strength Dependence For Homopolymer Peg: Open Porementioning
confidence: 75%