Macronutrient intake and outcomes of ICU patients with refeeding hypophosphatemia

Slingerland-Boot, Rianne; Rooijakkers, EF; WAC, Koekkoek; Blokland, Dick van; Arbous, Sesmu; Zanten, Arthur R. H. van

doi:10.1016/j.clnesp.2023.03.003

Cited by 6 publications

(1 citation statement)

References 39 publications

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“…Early high protein intake may worsen clinical outcomes, as has been shown in an observational study and posthoc analyses of randomized controlled trials (RCTs) [22][23][24]. Recently, our group also found associations with increased mortality of high protein intake during the emergence of refeeding hypophosphatemia [25]. Therefore, guidelines have recommended gradual progression to the protein intake target [1].…”

Section: Individualised Protein Strategymentioning

confidence: 63%

Editorial: Personalized nutrition therapy in critical illness and convalescence: moving beyond one-size-fits-all to phenotyping and endotyping

Zanten

2023

Current Opinion in Critical Care

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Section: Individualised Protein Strategymentioning

confidence: 63%

Editorial: Personalized nutrition therapy in critical illness and convalescence: moving beyond one-size-fits-all to phenotyping and endotyping

Zanten

2023

Current Opinion in Critical Care

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Prevalence, predictive factors, and outcomes of refeeding syndrome among medically critically ill patients: A retrospective cohort study

Tongyoo,

Rawangban,

Naorungroj

2024

Nut in Clin Prac

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BackgroundRefeeding syndrome (RFS) is a life‐threatening metabolic derangement occurring when nutrition is reintroduced after prolonged starvation. Limited data exist regarding RFS prevalence, risk factors, and outcome, particularly in critically ill patients.MethodsA retrospective cohort study was conducted in a medical intensive care unit from June 2018 to August 2020. RFS diagnostic criteria from the National Institute for Health and Care Excellence (NICE) and the American Society for Parenteral and Enteral Nutrition (ASPEN) were used. The primary outcome was 30‐day mortality.ResultsAmong 216 patients, RFS was diagnosed in 22.7% and 27.3% of patients per the NICE and ASPEN criteria, respectively. There was no significant difference in 30‐day mortality between patients with and without RFS (22/59 [37.3%] vs 53/157 [33.8%]; P = 0.627). Independent predictors of RFS were malignancy (odds ratio [OR] = 2.09; 95% CI = 1.06–4.15; P = 0.035), septic shock (OR = 2.26; 95% CI = 1.17–4.39; P = 0.016), and high NICE RFS risk classification (OR = 2.52; 95% CI = 1.20–5.31; P = 0.015). Factors associated with reduced RFS risk were Sequential Organ Failure Assessment (SOFA) scores >12 (OR = 0.45; 95% CI = 0.23–0.88; P = 0.020) and high‐dose vasopressor treatment (OR = 0.34; 95% CI = 0.14–0.79; P = 0.012).ConclusionRFS affected one‐fourth of the critically ill patients but did not significantly impact 30‐day mortality. Malignancy, septic shock, and high NICE RFS risk classification were positively associated with RFS, whereas high SOFA scores and extensive vasopressor use were linked to decreased risk.

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Proteins—What Have Recent Trials Shown Us?

Paulus,

van Zanten

2024

Critical Care Clinics

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Macronutrient intake and outcomes of ICU patients with refeeding hypophosphatemia

Cited by 6 publications

References 39 publications

Editorial: Personalized nutrition therapy in critical illness and convalescence: moving beyond one-size-fits-all to phenotyping and endotyping

Editorial: Personalized nutrition therapy in critical illness and convalescence: moving beyond one-size-fits-all to phenotyping and endotyping

Prevalence, predictive factors, and outcomes of refeeding syndrome among medically critically ill patients: A retrospective cohort study

Proteins—What Have Recent Trials Shown Us?

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