Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease

Cheng, Chih Mei; Hsieh, Chong Chao; Lin, Cheng-Yu; Dai, Zen Kong; Shih, Pin‐Keng; Everett, Mary Lou; Thomas, Anitra D.; Parker, William; Davis, Robert D.; Lin, Song

doi:10.1016/j.imbio.2009.02.001

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…*p \ 0.05, **p \ 0.01, ***p \ 0.005 Chronic aspiration shifts immunity 869 laden pathology [32]. Our previous in vitro study showed that Toll-like receptor (TLR)-4-dependent pathway and NF-jB are both involved in mouse macrophage activation by gastric fluid, further supporting the role of gastric fluidassociated bacteria in the pathogenesis [33]. Another study showed that lipopolysaccharides (LPS) enhance the cellular response to allergen in patients with allergic asthma [34].…”

Section: Discussionmentioning

confidence: 88%

Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma

Thomas

Chang

et al. 2012

Inflamm. Res.

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Section: Discussionmentioning

confidence: 88%

Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma

Thomas

Chang

et al. 2012

Inflamm. Res.

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“…The imbalance between MMPs and TIMPs may lead to the migration of inflammatory cells such as eosinophils and mast cells to the nasal mucosa of AR patients, which suggested that MMPs might play a positive role in the occurrence of AR. According to an animal study, gastric juice can activate the secretion of inflammatory cytokines in mouse cells (RAW264.7), activate NF-KB signaling pathway, and activate MMP-2 and MMP-9 [23]. Therefore, LPR may promote the occurrence of AR.…”

Section: Discussionmentioning

confidence: 99%

A Characterization Study of the Patients Visiting Hospital due to Laryngopharyngeal Reflux Suspicion: A Prospective Case-Control Study

Chang

Qiu

Qin

et al. 2022

Int Arch Allergy Immunol

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Background: This study aimed to explore the characteristics of laryngopharyngeal reflux (LPR) and the association between LPR and allergic rhinitis (AR). Methods: In this prospective case-control study, a total of 102 patients with suspected LPR who visited the Department of Otolaryngology Head and Neck Surgery, Heping Hospital Affiliated to Changzhi Medical College, between June 2019 and June 2021 were consecutively included. They were divided into the LPR-positive group and the LPR-negative group according to 24-h Dx-pH monitoring. The influencing factors of LPR, including the scores for AR (SFAR) and AR prevalence, were compared between the two groups. Results: The total SFAR and scores in items 1, 3, 4, and 5 of the LPR-positive group were significantly higher than those of the LPR-negative group (p < 0.05). The prevalence of AR in the LPR-positive group was 60%, which was significantly higher than that in the LPR-negative group (36.54%) (p < 0.05). After excluding confounding factors, AR was positively correlated with the incidence of LPR, and the incidence of LPR with AR was 2.372 times that of non-AR. Receiver operating characteristic curve results show that AR has the highest predictive value for LPR, and the area of AR under the curve is was 0.617. Conclusions: The SFAR and incidence of AR are high in patients with positive LPR, and AR may be a risk factor for LPR. The results of this study may deepen our understanding of the occurrence of LPR.

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“…One key aspect in deciding feeding risk is understanding the data on aspiration complications. Most literature focuses on large volume aspiration in animal models, whereas the airway injury seems to be related to acidity, type of feeding (clear, milk, particulate matter) and volume of gastric contents, the generalizability to humans is not known (18)(19)(20)(21). Most pediatric aspiration is due to chronic small volume aspiration (22,23).…”

Section: Risk Of Aspirationmentioning

confidence: 99%

The Ethics of Feeding the Aspirating Child in an Age of Increasing Patient Complexity

Rosen

Kamin²,

Simoneau³

et al. 2020

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Submissions for the Topic of the Month should include high-quality TIF endoscopic images of unusual or informative findings. In addition, 1 or 2 other associated photographs, such as radiological or pathological images, can be submitted. A brief description of no more than 200 words should accompany the images. Submissions are to be made online at www.jpgn.org, and will undergo peer review by members of the NASPGHAN Endoscopy and Procedures Committee, as well as by the Journal.

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Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease

Cited by 10 publications

References 40 publications

Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma

Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma

A Characterization Study of the Patients Visiting Hospital due to Laryngopharyngeal Reflux Suspicion: A Prospective Case-Control Study

The Ethics of Feeding the Aspirating Child in an Age of Increasing Patient Complexity

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