Macrophage Activation Syndrome as a Severe Manifestation of Adult's Still's Disease. Hemophagocytic Cells in Ascites

Dubuc, César Egües; Ecenarro, Miren Uriarte; Aguirre, Nerea Errazquin; Otano, Joaquín Belzunegui

doi:10.1016/j.reumae.2014.04.003

Cited by 2 publications

(2 citation statements)

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“…This triggered a repeat bone marrow biopsy now showing hemophagocytosis, which along with worsening cytopenias confirmed the diagnosis of HLH. This finding of hemophagocytosis on ascitic fluid has rarely been reported 9,10 . In addition to being a rare occurrence, this case illustrates the challenges in diagnosing HLH.…”

Section: Discussionmentioning

confidence: 58%

“…In addition, hemophagocytosis can be a physiologic finding following blood transfusion or surgery, or may be seen in infections, malignancies, and other acute illnesses 7,8 . Hemophagocytosis in the ascitic fluid has rarely been reported in HLH 9,10 . Here, we report the case of a patient who presented with fever and abdominal distention and ascites.…”

Section: Introductionmentioning

confidence: 92%

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Hemophagocytosis on ascitic fluid cytology: Diagnosis of HLH

Shaar

Perry

Otrock

2022

Diagnostic Cytopathology

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Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening syndrome of pathologic immune response characterized by excessive activation of macrophages. Hemophagocytosis is one of the diagnostic criteria for HLH, and it usually involves the bone marrow, spleen, lymph nodes, or any part of the reticuloendothelial system. Hemophagocytosis in the ascitic fluid has rarely been reported in HLH. Here, we report the case of a patient who presented with fever and abdominal distention and ascites. Ascitic fluid cytology showed hemophagocytosis which was the clue for HLH diagnosis. We also review the literature for this rare cytological occurrence.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 92%

Hemophagocytosis on ascitic fluid cytology: Diagnosis of HLH

Shaar

Perry

Otrock

2022

Diagnostic Cytopathology

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Rare cause of natural death in forensic setting: hemophagocytic syndrome

et al. 2015

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We report about the case of a sudden unexpected death of a 25-year-old male suffering from infectious disease. An autopsy was ordered with no final premortem diagnosis. Microscopic and microbiological examination revealed a pneumococcal bronchopneumonia and hemophagocytic lesions in the bone marrow. After integrating clinical and autopsy reports as well as additional postmortem investigations, the cause of death was found to be infectious-triggered hemophagocytic syndrome (HPS) with a final cytokine storm. This seems to be the first reported fatal case of a reactive form of HPS associated to Streptococcus pneumoniae to the best of our knowledge. HPS is a dangerous hyperinflammation with highly characteristic, but nonspecific, laboratory findings and symptoms. Autopsies in such cases must be carefully performed and include systematic tissue sampling done by an experienced pathologist.

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Macrophage Activation Syndrome as a Severe Manifestation of Adult's Still's Disease. Hemophagocytic Cells in Ascites

Cited by 2 publications

References 7 publications

Hemophagocytosis on ascitic fluid cytology: Diagnosis of HLH

Hemophagocytosis on ascitic fluid cytology: Diagnosis of HLH

Rare cause of natural death in forensic setting: hemophagocytic syndrome

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