Macrophage‐Capturing Self‐Assembly Photosensitizer Nanoparticles Induces Immune Microenvironment Re‐Programming and Golgi‐Responsive Immunogenic Cell Death in Head and Neck Carcinoma

Abstract

Head and neck carcinoma treatment has been shifted towards the combination of therapy causing immune checkpoint blockade (ICB) and immunogenic cell death (ICD). In this study,we developed a CSFRi‐chimeric TAMCSFR+‐targeting extracellular vesicle (EV@CSFRi) platform and designed an intracellular protoporphyrin conjugated with RVRR peptide sequence for furin‐cleavage to perform Golgi‐targeting and generating ROS (GT‐RG). Graphical abstract illustrates the self‐assembly of GT‐RG nanoparticles into nanofiber through hydrophily of RVRR and hydrophobicity of RG, and the red line indicates the site of furin cleavage. As is shown in the Graphical abstract, the Golgi‐targeting Protoporphyrin‐RVRR platform is composed with CSFRi‐chimeric extracellular vesicles and forms the tumor‐responsive TAM‐reprogramming bilayers (GT‐RGEV@CSFRi). The GT‐RGEV@CSFRi acted as a multifunctional theranostic platform, which could induce immunogenic cell death and further help modulate TAM, thus suppressing HNC xenograft model by combination therapy with anti‐PD‐1.This article is protected by copyright. All rights reserved

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

“…Besides the established treatment of HNC based on (radio)chemotherapy, combined treatment schedules including immune checkpoint inhibitors, such as pembrolizumab, have revealed improved prognosis in clinical studies, offering new hope to patients with advanced or recurrent disease [122]. Zhou et al have addressed this shift of HNC therapy towards immunotherapy in a recent study [123]. The authors designed an extracellular vesicle-based intelligent nanoplatform, which is able to respond to and modulate the tumor microenvironment, thereby inducing immunogenic cell death.…”