Macrophage Class A Scavenger Receptors – A Functional Perspective

Gordon, Siamon; Chung, Matthew Wai Heng; Harris, Scarlett L.; Martinez-Estrada, Fernando; Mukhopadhyay, Subhankar

doi:10.1016/b978-0-12-821618-7.00255-8

Encyclopedia of Cell Biology 2023

DOI: 10.1016/b978-0-12-821618-7.00255-8

|View full text |Cite

Macrophage Class A Scavenger Receptors – A Functional Perspective

Siamon Gordon¹,

Matthew Wai Heng Chung²,

Scarlett L. Harris³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 143 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Mononuclear Phagocytes, Cellular Immunity, and Nobel Prizes: A Historic Perspective

Gordon,

Roberti,

Kaufmann

2024

Cells

View full text Add to dashboard Cite

The mononuclear phagocyte system includes monocytes, macrophages, some dendritic cells, and multinuclear giant cells. These cell populations display marked heterogeneity depending on their differentiation from embryonic and bone marrow hematopoietic progenitors, tissue location, and activation. They contribute to tissue homeostasis by interacting with local and systemic immune and non-immune cells through trophic, clearance, and cytocidal functions. During evolution, they contributed to the innate host defense before effector mechanisms of specific adaptive immunity emerged. Mouse macrophages appear at mid-gestation and are distributed throughout the embryo to facilitate organogenesis and clear cells undergoing programmed cell death. Yolk sac, AGM, and fetal liver-derived tissue-resident macrophages persist throughout postnatal and adult life, supplemented by bone marrow-derived blood monocytes, as required after injury and infection. Nobel awards to Elie Metchnikoff and Paul Ehrlich in 1908 drew attention to cellular phagocytic and humoral immunity, respectively. In 2011, prizes were awarded to Jules Hoffmann and Bruce Beutler for contributions to innate immunity and to Ralph Steinman for the discovery of dendritic cells and their role in antigen presentation to T lymphocytes. We trace milestones in the history of mononuclear phagocyte research from the perspective of Nobel awards bearing directly and indirectly on their role in cellular immunity.

show abstract

Mononuclear Phagocytes, Cellular Immunity, and Nobel Prizes: A Historic Perspective

Gordon,

Roberti,

Kaufmann

2024

Cells

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Macrophage Class A Scavenger Receptors – A Functional Perspective

Cited by 1 publication

References 143 publications

Mononuclear Phagocytes, Cellular Immunity, and Nobel Prizes: A Historic Perspective

Mononuclear Phagocytes, Cellular Immunity, and Nobel Prizes: A Historic Perspective

Contact Info

Product

Resources

About