Macrophage Function in Senescence

Finger, H; B, Heymer; König, Carl Heinz Wirsing von; Emmerling, P

doi:10.1159/000212537

Cited by 26 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors state that macrophage function does not decline with age ( Sondell et al . 1990 ), while others have found a diminished function ( De la Fuente 1985), or a stimulation of such phagocytic activity ( Finger et al . 1982 , De la Fuente et al .…”

Section: Discussionmentioning

confidence: 97%

“…Some studies have established that these functions do not decline with age ( Makinodan & Kay 1980, Sondell et al . 1990 ); other authors have found a diminished function at certain stages of the phagocytic process ( De la Fuente 1985), whereas still others have observed a stimulation of the capacity of the monocyte–macrophage system ( Finger et al . 1982 , Ortega et al .…”

mentioning

confidence: 98%

See 1 more Smart Citation

Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages

Ferrández

Fuente

1999

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

Different stages of the phagocytic process, i.e. chemotaxis, ingestion of latex beads and superoxide anion production, were measured in peritoneal macrophages from young (12 +/- 2 weeks old) and old (60 +/- 2 weeks old) male and female BALB/C mice, which were subjected to an acute bout of exercise (swimming until exhaustion) or to a period of training exercise (90 min of swimming each day during 20 days). Sedentary male and female mice as well as young and old animals were used as sex and age controls. The results show that both acute and training exercise stimulate the phagocytic process of murine peritoneal macrophages. The macrophage functions from sedentary controls were lower in the old than in the young animals. The chemotaxis and ingestion capacities of macrophages were higher in the female young and old sedentary mice than in their male counterparts. After exercise, the stimulation of the phagocytic process was higher in old and female mice than in young and male animals. In addition, serum corticosterone levels were measured in order to investigate the relations between stress and macrophage activity. Old and female mice as well as animals subjected to exercise showed, in general, higher corticosterone levels than young, male and sedentary animals.

show abstract

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 98%

Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages

Ferrández

Fuente

1999

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…Due to fear of reactions following vaccination, pertussis immunization was not recommended in Germany from 1974 to 1991 [2,8].As a consequence, the low acceptance of the vaccination by pediatricians and parents led to a marked increase in the incidence of pertussis to about 100-180 cases/100,000 persons/year [2,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Hospitalization and Complications in Children under 2 Years of Age with Bordetella pertussis Infection

Stojanov¹,

Jg²,

Belohradsky³

2000

Infection

View full text Add to dashboard Cite

We prospectively followed 725 children under 2 years of age with laboratory-diagnosed Bordetella pertussis infection to investigate the hospitalization rate and complications. Diagnosis was made by culture and polymerase chain reaction (PCR) from nasopharyngeal swabs in 11,016 children who presented with > or = 7 days of cough at 63 pediatric practices in Germany. Of these children, 33 (4.5%) were hospitalized at a mean age of 4.8 months (range, 17 days to 19.5 months). Complications occurred in 16 (48%) of the 33 patients. Pneumonia developed in two (6%) children and a convulsion was observed in one (3%). Intensive care monitoring was required for 23 (70%) children. Further complications were bradycardia (21%), apnea (12%), conjunctivitis (12%), loss of weight (12%), otitis media (6%), atelectasis (3%) and dehydration (3%). Children aged 6-24 months who had not received any dose of pertussis vaccine had a ten-fold increased risk of hospitalization compared to those who had been partially or fully immunized (p < 0.05). Pertussis immunization should be given at an early point in time and completely in order to prevent severe courses of pertussis and hospitalization in young children.

show abstract

“…It is known that aging is accompanied by a decline in immune response [4], although there are controversial findings in several immune functions. Some authors [5] studying the immune system in aging showed no change of macrophage function due to aging; the changes in the functional capacity of inflammatory cells are ranging from decreased to increased [3,6,7].…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>L</i>-Carnitine on Carrageenan-Induced Inflammation in Aged Rats

İzgüt‐Uysal

Ağaç

Derın³

2003

Gerontology

View full text Add to dashboard Cite

Background: It is known that L-carnitine is a cofactor in the transport of fatty acids across the inner mitochondrial membrane for β-oxidation. However, L-carnitine is an antioxidant compound widely used for the treatment of deficits in functions due to the aging process. Objective: The purpose of the study was to investigate the effect of L-carnitine on carrageenan-induced inflammation in aged rats. Methods:L-Carnitine (50 mg/kg/day) or control vehicle was given by gavage for 30 consecutive days to young (2-month-old) and aged (24-month old) rats. 6 ml of air was injected subcutaneously into the dorsum of each rat, followed 2 days later by 4 ml of 2% carrageenan. After 2 days, the exudate was collected from the inflamed site of each rat. The quantity of collected exudate and the number of cells which have migrated to the inflamed site were determined. Results: No differences were observed in quantity of exudate in all groups; a decrease in the number of exudate cells was established in aged rats. However, L-carnitine treatment significantly increased the number of exudate cells in both young and aged rats. The exudate cells from the aged rats exhibited a decline of both phagocytic and chemotactic activities as compared with those from the young rats, and the decreased functions were significantly enhanced by L-carnitine treatment. However, superoxide anion release was seen to be unchanged in exudate cells due to aging, and L-carnitine intake decreased the production of superoxide anion by these cells in young and aged rats. Conclusions: These findings demonstrate that L-carnitine is capable of restoring the age-related changes in the functions of inflammatory cells. Moreover, L-carnitine may play a protective role in the tissue destruction in inflammation by decreasing the superoxide anion production.

show abstract

Macrophage Function in Senescence

Cited by 26 publications

References 8 publications

Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages

Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages

Hospitalization and Complications in Children under 2 Years of Age with Bordetella pertussis Infection

Effect of <i>L</i>-Carnitine on Carrageenan-Induced Inflammation in Aged Rats

Contact Info

Product

Resources

About