Macrophage Lxrα reduces atherosclerosis in Ldlr−/− mice independent of Arl7 transactivation

New insights into the suppression of inflammation and lipid accumulation by JAZF1

“…Interestingly, the promoters of ACC , 58 FAS , 59 , 60 FABP4 , 61 and SCD-1 62 also contain LXREs . Other lipid metabolism genes also contain LXREs , including ABCA1 , 63 , 64 ABCG1 , 65 , 66 long-chain acyl-CoA synthetases 3 ( ACSL3 ), 67 angiopoietin-like protein 3 ( Angptl3 ), 68 3alpha-hydroxysteroid dehydrogenase ( AKR1C4 ), 69 ADP ribosylation factor like GTPase 4C ( Arl4c , also named Arl7 ), 70 α-tocopherol transfer protein ( α-TTP ), 71 cholesteryl ester transfer protein ( CETP ), 72 cholesterol 25-hydroxylase ( CH25H ), 73 cholesterol 7-alpha-hydroxylase ( CYP7A1 ), 74 ileal bile acid-binding protein ( I-BABP ), 75 lysophosphatidylcholine acyltransferase 3 ( LPCAT3 ), 76 lipoprotein lipase ( LPL ), 77 midline-1-interacting G12-like protein ( MIG12 ), 78 organic solute transporter alpha/beta ( Ostalpha/beta ), 79 phospholipid transfer protein ( PLTP ), 80 group IIA secretory phospholipase A2 ( sPLA2 ), 81 SR-BI , 82 sulfotransferase family 1E ( Sult1e1 ), 83 and UDP-glucuronosyltransferase 1A3 ( UGT1A3 ). 84 Because JAZF1 regulates SREBP-1c expression via LXREs , we hypothesized that JAZF1 could regulate lipid metabolism by binding to the LXREs of these genes ( Fig.…”