Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics

Zhang, Bin; Yang, Rui; Yu, Hongwei; Peng, Yamin; Huang, Haoyu; Hameed, Meera Moydeen Abdul; Wang, Han; Zhang, Guixiang; EL-Newehy, Mohamed; Shen, Mingwu; Shi, Xiangyang; Peng, Shaojun

doi:10.1039/d4bm00357h

Biomater. Sci.

2024

DOI: 10.1039/d4bm00357h

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Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics

Bin Zhang,

Rui Yang,

Hongwei Yu

et al.

Abstract: Developing effective nanomedicines to cross the blood-brain barrier (BBB) for efficient glioma theranostics is still considered to be a challenging task. Here, we describe the development of macrophage membrane (MM)-coated...

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Cited by 5 publications

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Dendrimer‐Cu(II) Complexes Mediate Enzyme Delivery for Lactate Depletion‐Enhanced Combinational Treatment of Leukemia and Glioma

Li,

Gao,

Xiao

et al. 2024

Adv Funct Materials

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Cancer cells engage in active aerobic glycolysis to meet their bioenergetic synthesis needs, which is known as the Warburg effect. Such a process leads to lactate accumulation in the tumor microenvironment (TME), further promoting cancer progression and inducing immunosuppression. Herein, functionalized dendrimer‐Cu(II) complexes (for short, D‐Cu(II)) as a nanocarrier, which enables a Fenton‐like reaction is developed to generate a large amount of hydroxyl radicals and shows a T1‐weighted magnetic resonance (MR) imaging performance. Importantly, the D‐Cu(II) allows efficient delivery of lactate oxidase (LOx) to cancer cells, directly downregulating the lactate levels. When combining with an immune activator of leukadherin‐1, the developed D‐Cu(II)/LOx complexes alleviate the symptoms of mouse leukemia. With a further coating of macrophage membranes, the generated D‐Cu(II)/LOx@M allows for effective blood‐brain barrier crossing to treat an orthotopic murine glioma model under the guidance of Cu(II)‐facilitated MR imaging. By integrating the LOx‐mediated lactate depletion with Cu(II)‐mediated chemodynamic therapy, the developed dendrimer nanomedicines improve the overall survival and antitumor immune responses of mice, and help to remodel the immunosuppressive TME in both cancer models, greatly sensitizing the treatment efficacy of immune activator. Such dendrimer technology may further be used for theranostics of other cancer types through lactate depletion‐enhanced combinational therapy.

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Dendrimer‐Cu(II) Complexes Mediate Enzyme Delivery for Lactate Depletion‐Enhanced Combinational Treatment of Leukemia and Glioma

Li,

Gao,

Xiao

et al. 2024

Adv Funct Materials

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Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers

Banerjee,

Biswas,

Shukla

et al. 2024

ChemMedChem

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Stimuli activatable systems have the potential to deliver drugs to targeted areas by releasing therapeutic agents in response to diseased specific microenvironments such as the acidic environment commonly found in diseased tissues. This review article focuses on gossypol, a bioactive compound with inherent toxicity due to its formyl groups. It highlights the potential of imine‐linked gossypol‐based prodrugs and nanoparticle formulations for targeted delivery and controlled release. The unique presence of polyphenolic cores on gossypol can be utilized to prepare nanoparticles. This review offers valuable insights into designing safer and more effective drug delivery systems by elucidating the masking effect and stimuli‐responsive release mechanisms. Numerous examples demonstrate the conversion of formyl groups to imines, creating prodrugs that mask reactive functionalities and offer pH‐responsive release. This insight can guide the design of combination therapeutics, where a second drug with an amine terminal group can form imine‐linked prodrugs. Additionally, the second part discusses the use of polyphenolic moieties to create stable nanoparticles from infinite polymeric networks. Through a comprehensive examination of gossypol's properties and applications, this review emphasizes the broader implications of such a masking strategy for optimizing the therapeutic benefits of many similar bioactive compounds while minimizing adverse effects.

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Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations

Caverzan,

Ibarra

2024

International Journal of Biological Macromolecules

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Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles for precision glioma theranostics

Abstract: Developing effective nanomedicines to cross the blood-brain barrier (BBB) for efficient glioma theranostics is still considered to be a challenging task. Here, we describe the development of macrophage membrane (MM)-coated...

Cited by 5 publications

References 46 publications

Dendrimer‐Cu(II) Complexes Mediate Enzyme Delivery for Lactate Depletion‐Enhanced Combinational Treatment of Leukemia and Glioma

Dendrimer‐Cu(II) Complexes Mediate Enzyme Delivery for Lactate Depletion‐Enhanced Combinational Treatment of Leukemia and Glioma

Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers

Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations

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