Macrophage membrane-modified targeted phase-change nanoparticles for multimodal imaging of experimental autoimmune myocarditis

Yin, Dan; Zheng, Min; Zhang, Qin; Li, Mi; Xiang, Ping; Tian, Jie

doi:10.1039/d3nr05391a

Nanoscale

2024

DOI: 10.1039/d3nr05391a

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Macrophage membrane-modified targeted phase-change nanoparticles for multimodal imaging of experimental autoimmune myocarditis

Dan Yin,

Min Zheng,

Qin Zhang

et al.

Abstract: Myocarditis is an important public health issue due to the high prevalence of sudden death in adolescents and young adults. Nevertheless, the early identification of myocarditis remains a serious problem...

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2024

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Cited by 2 publications

References 45 publications

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Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy

Wang,

Liu,

et al. 2024

Small

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Immunotherapy involving PDL1 degradation holds great potential in anti‐tumor treatment. Optimal design of PDL1 degraders and subsequent efficient delivery into tumors are essential for expected efficacy, especially when abnormal tumor vasculature is considered. Herein, a nanodroplet‐based novel drug delivery platform termed as NDsmTx (nanodroplet‐based therapeutics) for ultrasound targeted delivery of PDL1 degrader is designed. Briefly, the shell of the NDsmTx is armed with RGD and mPD1 (a bioorthogonal PD1 mutant produced by genetic codon expansion technology can covalently bind PDL1), and the core is composed of perfluorohexane (PFH, C6F14). The RGD on the NDsmTx recognizes αvβ3 expressed by tumor vasculature, making NDsmTx accumulated in tumor practical and visible by low‐frequency ultrasound (LFUS). In turn, inertial cavitation induced by LFUS facilitates mPD1 on the nanodroplet debris penetrating the tumor, where mPD1 covalently binds PDL1 and initiates a lysosomal degradation process. Through both in vitro and in vivo study, the superior performance of NDsmTx in degrading PDL1 and boosting anti‐tumor immunity is confirmed. In conclusion, NDsmTx emerge as an alternative to existing PDL1 blockers in tumor immunotherapy.

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Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy

Wang,

Liu,

et al. 2024

Small

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Engineered macrophages: an “Intelligent Repair” cellular machine for heart injury

Zhang,

Du,

Gao

et al. 2024

Cell Regen

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Macrophages are crucial in the heart’s development, function, and injury. As part of the innate immune system, they act as the first line of defense during cardiac injury and repair. After events such as myocardial infarction or myocarditis, numerous macrophages are recruited to the affected areas of the heart to clear dead cells and facilitate tissue repair. This review summarizes the roles of resident and recruited macrophages in developing cardiovascular diseases. We also describe how macrophage phenotypes dynamically change within the cardiovascular disease microenvironment, exhibiting distinct pro-inflammatory and anti-inflammatory functions. Recent studies reveal the values of targeting macrophages in cardiovascular diseases treatment and the novel bioengineering technologies facilitate engineered macrophages as a promising therapeutic strategy. Engineered macrophages have strong natural tropism and infiltration for cardiovascular diseases aiming to reduce inflammatory response, inhibit excessive fibrosis, restore heart function and promote heart regeneration. We also discuss recent studies highlighting therapeutic strategies and new approaches targeting engineered macrophages, which can aid in heart injury recovery.

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Macrophage membrane-modified targeted phase-change nanoparticles for multimodal imaging of experimental autoimmune myocarditis

Abstract: Myocarditis is an important public health issue due to the high prevalence of sudden death in adolescents and young adults. Nevertheless, the early identification of myocarditis remains a serious problem...

Cited by 2 publications

References 45 publications

Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy

Ultrasound Guided Local Delivery of Bioorthogonal PDL1 Degrader for Enhanced Immunotherapy

Engineered macrophages: an “Intelligent Repair” cellular machine for heart injury

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