Macrophage migration inhibitory factor derived from spinal cord is involved in activation of macrophages following gecko tail amputation

Wang, Yingjie; Wei, Sumei; Song, Honghua; Zhang, Xuejie; Wang, Wenjuan; Du, Nan; Song, Tiancheng; Liang, Hao; Chen, Xiaojun; Wang, Yongjun

doi:10.1096/fj.201801966rrr

Cited by 12 publications

(20 citation statements)

References 48 publications

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“…Besides functioning in phagocytosis and killing bacteria, they also release proteases, chemokines, and growth factors which will stimulate cell proliferation and migration within the damaged tissues [ 39 , 40 ]. After the loss of the tail, heterophils, a kind of granulocytes equivalent to the mammalian neutrophils, are recruited to the wound site to participate in phagocytosis of tissue debris and defense of various microbes [ 23 , 41 , 42 , 43 ]. Immunostaining reveals that these heterophils upregulate the expression of β-defensins, including AcBD15, to inhibit rather than trigger the inflammation [ 23 ].…”

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

“…The tail amputation of lizards inevitably triggers monocytes/macrophages to participate in the process of wound healing and subsequent regeneration. A large amount of macrophages have been observed within the damaged tissues or underneath the wounded epithelium following tail loss [ 23 , 43 ]. Though few mechanisms of the injury-induced recruitment of macrophages have been elucidated, the proinflammatory cytokines or chemokines are undoubtedly the main contributors of such cell events [ 34 , 35 , 36 , 37 , 43 ].…”

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

“…A large amount of macrophages have been observed within the damaged tissues or underneath the wounded epithelium following tail loss [ 23 , 43 ]. Though few mechanisms of the injury-induced recruitment of macrophages have been elucidated, the proinflammatory cytokines or chemokines are undoubtedly the main contributors of such cell events [ 34 , 35 , 36 , 37 , 43 ]. For example, macrophage migration inhibitory factor (MIF) derived from spinal cord plays a key role in the recruitment of the macrophages to the injured sites of spinal cord following gecko tail amputation.…”

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

“…The recruited macrophages have been found to be involved in the phagocytosis of pathogens or tissue debris. Experiments on both lizards and amphibian models have clearly demonstrated that infiltration of macrophages to the damaged sites is essential for successful appendage regeneration [ 43 , 44 ]. The deletion of the cells by clodronate liposomes results in wound closure but the permanent failure of regeneration [ 43 , 44 ].…”

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

“…Experiments on both lizards and amphibian models have clearly demonstrated that infiltration of macrophages to the damaged sites is essential for successful appendage regeneration [ 43 , 44 ]. The deletion of the cells by clodronate liposomes results in wound closure but the permanent failure of regeneration [ 43 , 44 ]. In addition, macrophages have been shown to be necessary for the epimorphic regeneration of organs in African spiny mice, suggesting the importance of the macrophages in the modulation of appendage regeneration [ 45 ].…”

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

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Self-Control of Inflammation during Tail Regeneration of Lizards

Song

Wang

2021

JDB

Self Cite

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Lizards can spontaneously regenerate their lost tail without evoking excessive inflammation at the damaged site. In contrast, tissue/organ injury of its mammalian counterparts results in wound healing with a formation of a fibrotic scar due to uncontrolled activation of inflammatory responses. Unveiling the mechanism of self-limited inflammation occurring in the regeneration of a lizard tail will provide clues for a therapeutic alternative to tissue injury. The present review provides an overview of aspects of rapid wound healing and roles of antibacterial peptides, effects of leukocytes on the tail regeneration, self-blocking of the inflammatory activation in leukocytes, as well as inflammatory resistance of blastemal cells or immature somatic cells during lizard tail regeneration. These mechanistic insights of self-control of inflammation during lizard tail regeneration may lead in the future to the development of therapeutic strategies to fight injury-induced inflammation.

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Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

Section: Infiltration Of Leukocytes To the Wounded Tailmentioning

confidence: 99%

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Self-Control of Inflammation during Tail Regeneration of Lizards

Song

Wang

2021

JDB

Self Cite

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Gradual specialization of phagocytic ameboid cells may have impaired regenerative capacities in metazoan lineages

Lima

Abrahão

Pentagna

et al. 2022

Developmental Dynamics

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Animal regeneration is a fascinating field of research that has captured the attention of many generations of scientists. Among the cellular mechanisms underlying tissue and organ regeneration, we highlight the role of phagocytic ameboid cells (PACs). Beyond their ability to engulf nutritional particles, microbes, and apoptotic cells, their involvement in regeneration has been widely documented. It has been extensively described that, at least in part, animal regenerative mechanisms rely on PACs that serve as a hub for a range of critical physiological functions, both in health and disease. Considering the phylogenetics of PAC evolution, and the loss and gain of nutritional, immunological, and regenerative potential across Metazoa, we aim to discuss when and how phagocytic activity was first co‐opted to regenerative tissue repair. We propose that the gradual specialization of PACs during metazoan derivation may have contributed to the loss of regenerative potential in animals, with critical impacts on potential translational strategies for regenerative medicine.

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Comparing RNA‐sequencing datasets from astrocytes, oligodendrocytes, and microglia in multiple sclerosis identifies novel dysregulated genes relevant to inflammation and myelination

Drake

Zaman

Simas

et al. 2023

WIREs Mechanisms of Disease

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Central nervous system (CNS) inflammation is a key factor in multiple sclerosis (MS). Invasion of peripheral immune cells into the CNS resulting from an unknown signal or combination of signals results in activation of resident immune cells and the hallmark feature of the disease: demyelinating lesions. These lesion sites are an amalgam of reactive peripheral and central immune cells, astrocytes, damaged and dying oligodendrocytes, and injured neurons and axons. Sustained inflammation affects cells directly located within the lesion site and further abnormalities are apparent diffusely throughout normal-appearing white matter and grey matter. It is only relatively recently, using animal models, new tissue sampling techniques, and next-generation sequencing, that molecular changes occurring in CNS resident cells have been broadly captured. Advances in cell isolation through Fluorescence Activated Cell Sorting (FACS) and laser-capture microdissection together with the emergence of single-cell sequencing have enabled researchers to investigate changes in gene expression in astrocytes, microglia, and oligodendrocytes derived from animal models of MS as well as from primary patient tissue. The contribution of some dysregulated pathways has been followed up in individual studies; however, corroborating results often go unreported between sequencing studies. To this end, we have consolidated results from numerous RNA-sequencing studies to identify and review novel patterns of differentially regulated genes and pathways occurring within CNS glial cells in MS.

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Macrophage migration inhibitory factor derived from spinal cord is involved in activation of macrophages following gecko tail amputation

Cited by 12 publications

References 48 publications

Self-Control of Inflammation during Tail Regeneration of Lizards

Self-Control of Inflammation during Tail Regeneration of Lizards

Gradual specialization of phagocytic ameboid cells may have impaired regenerative capacities in metazoan lineages

Comparing RNA‐sequencing datasets from astrocytes, oligodendrocytes, and microglia in multiple sclerosis identifies novel dysregulated genes relevant to inflammation and myelination

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