Macrophage Migration Inhibitory Factor Homologs of Anisakis simplex Suppress Th2 Response in Allergic Airway Inflammation Model via CD4+CD25+Foxp3+ T Cell Recruitment

Abstract

MaterialSupplementary http://www.jimmunol.org/content/suppl/2009/05/18/182.11.6907.DC1

Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients

“…This study shows for the first time that the EBV ϩ C666 cells co-cultured with CD4 Six cytokines were found in the culture medium of NPC tumor tissues, with MIF being found in the greatest amount. MIF, which is often secreted by naive CD4 ϩ T cells, can stimulate IL-17-producing cells in the lymph nodes of mice (27,45). However, the role of MIF in expanding the Th17 cell subset in human tumors is not known.…”

Parasite-Derived Proteins Inhibit Allergic Specific Th2 Response

“…IL-10 and TGF-β were produced primarily by T reg cells, and they are known to suppress immune response effects. The IL-10 and TGF-β levels measured in BALFs from rAs-MIFtreated asthma-induced mice were higher than those of the asthma-induced mice; the IL-10 and TGF-β levels occurred in accordance with their treated concentrations (59). The helminthic parasites stimulate the production of immunoregulatory mediators, which likely perform a function in the maintenance of the chronicity of infection, without any marked induction of pathology.…”

Climatic Factors Correlate with Innate Immune Response in Children with Dermatophagoides farinae-Induced Allergic Asthma

“…8 As a proinflammatory factor, MIF inhibits migration of macrophages and regulates T cell proliferation and activation; it also plays a regulatory role in chronic inflammation. 19,20 Eosinophils are an important source of MIF, especially in asthma patients. 21 Moreover, MIF and ECP have been shown synergistically to promote eosinophils to gather at inflammation sites and induce synthesis of leucotriene C 4 , leading to allergen-induced allergic inflammation.…”