Macrophage plays important role in cortisol and serotonin induced adipogenesis in vitro

Guha, Dipanjan; Mukherjee, Raktim; Aich, Palok

doi:10.1007/s11626-020-00482-1

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-adipocytes generate adipokines, paracrine factors, hormones and metabolic signals differently from mature adipose cells 18 . In addition, they exhibit robust innate immune responses to bacterial antigens, recruit macrophages and other immune effectors, as well as participate in the process of regulating the immunological activity of adipose tissue 19 . Thus, the gene expression profiles of these cells are closer to those of macrophages than to those of the fat cells themselves 20 .…”

Section: Introductionmentioning

confidence: 99%

Adipose Tissue Dysfunction: Impact on Metabolic Changes?

et al. 2022

View full text Add to dashboard Cite

Adipose tissue is a metabolically dynamic organ that is the primary site of storage for excess energy, but it serves as an endocrine organ capable of synthesizing a number of biologically active compounds that regulate metabolic homeostasis. However, when the capacity of expansion of this tissue is exceeded, dysfunction occurs, favoring ectopic accumulation of fat in the visceral, which has been implicated in several disease states, most notably obesity. This review highlights the mechanisms involved in the structure of adipose tissue, tissue expandability, adipocyte dysfunction, as well as the impact of these events on the manifestation of important metabolic disorders associated with adipose tissue dysfunction. A literature search using Pubmed, Web of Science, Scopus, and Cochrane databases were used to identify relevant studies, using clinical trials, experimental studies in animals and humans, case-control studies, case series, letters to the editor, and review articles published in English, without restrictions on year of publication.. The excessive ectopic lipid accumulation leads to local inflammation and insulin resistance. Indeed, overnutrition triggers uncontrolled inflammatory responses white adipose tissue, leading to chronic low-grade inflammation, therefore fostering the progression of important metabolic disorders. Thus, it is essential to advance the understanding of the molecular mechanisms involved in adipose tissue dysfunction in order to mitigate the negative metabolic consequences of obesity.

show abstract

Section: Introductionmentioning

confidence: 99%