Macrophage regulation of angiogenesis in health and disease

Martin, Paul; Gurevich, David

doi:10.1016/j.semcdb.2021.06.010

Cited by 59 publications

(36 citation statements)

References 112 publications

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“…Myeloid cells, and macrophages even more, are both sentinel cells controlling tissue hemostasis as well as regulators of pro-tumor inflammation due to their plasticity ( 52 , 53 ). Indeed, macrophages have pro- and also anti-tumor properties ( 18 , 52 – 54 ). Tumor-associated macrophages (TAM) are associated with a poor prognosis in cancer ( 18 , 25 , 29 , 52 , 53 , 55 , 56 ).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, macrophages have pro- and also anti-tumor properties ( 18 , 52 – 54 ). Tumor-associated macrophages (TAM) are associated with a poor prognosis in cancer ( 18 , 25 , 29 , 52 , 53 , 55 , 56 ). TAM controlled circulating cancer cell recruitment to the primary tumors and are involved in the metastatic cascade ( 29 , 53 , 55 , 57 , 58 ).…”

Section: Discussionmentioning

confidence: 99%

“…Intrinsic inflammation during immunosurveillance is a source of pro-inflammatory mediators (cytokines, DAMPs, growth factors) ( 16 , 17 ). This rich inflammatory environment is used by cancer cells to progress by growing, migrating and therefore encouraging metastasis formation ( 16 – 18 ). Finally, this escape favors an immunosuppressive environment not only from cancer cells but also immune cells, leading to a global shutdown of the immune system (named cold tumor).…”

Section: Introductionmentioning

confidence: 99%

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Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells

et al. 2022

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Cancers are consequences of cellular dysfunction leading to an aberrant cellular multiplication and proliferation, subsequently yielding metastasis formation. Inflammatory reaction, with immune cell recruitment, is the main defense against precancerous lesions. However, an inflammatory environment also favors cancer cell progression, with cancer cell evasion from immune surveillance, leading to cancer development. Current therapeutic strategies enhance this natural immune response in order to restore immunosurveillance. The variety of these strategies is a predominant source of inflammatory mediators used by cancer cells to grow, differentiate, and migrate, therefore encouraging metastasis formation. For this reason, during cancer progression, limiting inflammation appears to be an innovative strategy to avoid the escape of cancer cells and potentially enhance the efficacy of antitumor therapies. Thus, this study aims to investigate the impact of administering pro-resolving factors (SuperMApo® drug candidate), which are inducers of inflammation resolution, in the framework of cancer treatment. We have observed that administering pro-resolving mediators issued from apoptotic cell efferocytosis by macrophages controlled peritoneal cancer progression by limiting cancer cell dissemination to the blood and mesenteric lymph nodes. This observation has been linked to an increase of macrophage mobilization in both peritoneal cavity and mesenteric lymph nodes. This control is associated to a restricted immunosuppressive myeloid cell circulation and to an IFN-γ-specific anti-tumor T-cell response. Altogether, these results suggest that administering proresolving factors could provide a new additional therapeutic alternative to control cancer progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells

et al. 2022

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“…Macrophages are key players in inflammation and participate in the crosstalk between inflammation and cancer development ( Figure 1 ). In a typical inflammatory response, macrophages can perform three basic functions: 1) pathogen clearance, i.e., eliminating pathogens through phagocytosis or secreting anti-infective substances ( 5 – 7 ); 2) immune activation, i.e., activating humoral and cellular immune responses by presenting antigens to T cells and modifying the immune microenvironment by releasing a variety of inflammatory factors ( 8 – 10 ); and 3) tissue repair, i.e., releasing factors in the late stage of inflammation that promote angiogenesis, coordinating the functions of a variety of interstitial cells, and mediating the repair of local tissue structure ( 42 , 43 ). Macrophages can sense environmental stimuli and differentiate into functionally polarized subgroups ( 44 – 46 ), which is usually described as M1 or M2 differentiation, terms that were first used to describe the two functionally opposite statuses of macrophages that are induced in vitro ( 47 , 48 ).…”

Section: Macrophages Fundamentally Impact the Development Of Cancermentioning

confidence: 99%

Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

et al. 2022

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Macrophages play critical roles in tumor progression. In the tumor microenvironment, macrophages display highly diverse phenotypes and may perform antitumorigenic or protumorigenic functions in a context-dependent manner. Recent studies have shown that macrophages can be engineered to transport drug nanoparticles (NPs) to tumor sites in a targeted manner, thereby exerting significant anticancer effects. In addition, macrophages engineered to express chimeric antigen receptors (CARs) were shown to actively migrate to tumor sites and eliminate tumor cells through phagocytosis. Importantly, after reaching tumor sites, these engineered macrophages can significantly change the otherwise immune-suppressive tumor microenvironment and thereby enhance T cell-mediated anticancer immune responses. In this review, we first introduce the multifaceted activities of macrophages and the principles of nanotechnology in cancer therapy and then elaborate on macrophage engineering via nanotechnology or genetic approaches and discuss the effects, mechanisms, and limitations of such engineered macrophages, with a focus on using live macrophages as carriers to actively deliver NP drugs to tumor sites. Several new directions in macrophage engineering are reviewed, such as transporting NP drugs through macrophage cell membranes or extracellular vesicles, reprogramming tumor-associated macrophages (TAMs) by nanotechnology, and engineering macrophages with CARs. Finally, we discuss the possibility of combining engineered macrophages and other treatments to improve outcomes in cancer therapy.

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“…Tumor development, invasion and metastasis are highly dependent on neovascularization ( Goncalves et al, 2021 ; Rimini and Casadei-Gardini, 2021 ). Under physiological conditions, angiogenesis is intricately and precisely regulated by multiple molecules and mechanisms that allow the formation of highly tissue-specific, structured and hierarchical vascular networks to sustain the physiological processes of embryonic development, growth and tissue repair ( Lai et al, 2021 ; Martin and Gurevich, 2021 ; Narasimhan et al, 2021 ). However, tumor cells are able to release large amounts of vascular endothelial growth factor (VEGF) and inhibit the secretion of angiogenesis inhibitory factor, which unbalances the regulatory mechanism of angiogenesis, resulting in rapid, uncontrolled proliferation of tumor neovascularization and a large, abnormally disordered replenishment network ( Liu Y. et al, 2021 ; Uemura et al, 2021 ; Zhu et al, 2021 ).…”

Section: Biological Function and Molecular Mechanism Of Circular Rnas In Glioblastomamentioning

confidence: 99%

Research Progress of circRNAs in Glioblastoma

Guo

Piao

2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.

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Macrophage regulation of angiogenesis in health and disease

Cited by 59 publications

References 112 publications

Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells

Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells

Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

Research Progress of circRNAs in Glioblastoma

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