Macrophages and Lymphocyte Subpopulations in Nifedipine‐ and Cyclosporin A‐Associated Human Gingival Overgrowth

Pernu, Hannu; Knuuttila, Matti

doi:10.1902/jop.2001.72.2.160

Cited by 28 publications

(28 citation statements)

References 29 publications

(31 reference statements)

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“…Many studies have shown that drugs with immunomodulating effects always cause changes of lymphocyte subpopulations (15), which thus lead us to investigate the effects of SPMG on the T lymphocyte subset in peripheral blood mononuclear cells (PBMC) (Fig. 3).…”

Section: Spmg Enhanced the Ratio Of Cd4 Over Cd8 In T Lymphocytesmentioning

confidence: 99%

Potentiation of T Cell Function by a Marine Algae-Derived Sulfated Polymannuroguluronate: In Vitro Analysis of Novel Mechanisms

Xia

Geng

et al. 2005

J Pharmacol Sci

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Abstract. Marine algae-derived sulfated polymannuroguluronate (SPMG), a candidate drug for AIDS treatment, was intraperitoneally injected into normal mice for 6 weeks, and the in vivo and in vitro mechanisms of SPMG for immunomodulation were investigated in isolated lymphocytes by MTT assay, flow cytometry, and surface plasmon resonance assay. SPMG treatment at 5 and 10 mg / kg enhanced concanavalin A (ConA)-induced T cell proliferation, cellular levels of CD69, interleukin-2 (IL-2), and interferon-g (IFN-g), as well as CD4/ CD8 ratio, while decreasing tumor necrosis factor-a (TNF-a ) level in T cells of peripheral blood mononuclear cells. In addition, 1 molecule of SPMG bound to 2 / 3 molecules of IL-2 with a K D of 9.53´10 -7 M. Heparin prevented SPMG binding to IL-2 by 72.2%; thus, to a large extent, SPMG and heparin share common binding sites on IL-2. In contrast, other glycosaminoglycans (e.g., chondroitin sulfate and dermatan sulfate) had little effect on SPMG and IL-2 interaction, suggesting the requirement of a defined sequence within the sugar chain for specific recognition of IL-2. Concomitant treatment of IL-2 and SPMG augmented lymphocyte proliferation, compared with IL-2 alone; in contrast, SPMG alone had no proliferative effect. Taken together, our findings demonstrated for the first time that SPMG exerted its immunomodulation by direct activation of T cell function, accompanied by simultaneous modulation of cytokine function, which suggests that SPMG would show great promise for use in anti-AIDS therapy.

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Section: Spmg Enhanced the Ratio Of Cd4 Over Cd8 In T Lymphocytesmentioning

confidence: 99%

Potentiation of T Cell Function by a Marine Algae-Derived Sulfated Polymannuroguluronate: In Vitro Analysis of Novel Mechanisms

Xia

Geng

et al. 2005

J Pharmacol Sci

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“…3b). j-AAV-CsA animals showed persistent CD68 staining independently of circulating ARSB levels (data not shown), probably due to CsA side effects (Pernu and Knuuttila, 2001;Ghee et al, 2008). Importantly, in AF animals receiving CTLA4-Ig alone, either at birth or on P30 (AF þ CTLA4-Ig), tissue GAG accumulation (GAG levels: in the liver, 7.9 AE 0.3; in the kidney, 11.7 AE 0.7; in the spleen, 11.4 AE 0.3) and macrophage infiltration were similar to those observed in AF animals (Fig.…”

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confidence: 90%

Different Serum Enzyme Levels Are Required to Rescue the Various Systemic Features of the Mucopolysaccharidoses

et al. 2010

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Mucopolysaccharidoses (MPSs) are lysosomal storage disorders characterized by progressive accumulation of glycosaminoglycans (GAGs) in various tissues. Enzyme replacement therapy (ERT) for several MPSs is available to date. However, the efficacy of ERT is limited, in particular in compartments such as bone, cartilage, the brain, and the eyes. We selected a rodent model of an MPS, with no central nervous system storage, to study the impact, on systemic features of the disease, of various stable levels of exogenous enzymes produced by adeno-associated viral vector (AAV)-mediated liver gene transfer. Low levels (6% of normal) of circulating enzyme were enough to reduce storage and inflammation in the visceral organs and to ameliorate skull abnormalities; intermediate levels (11% of normal) were required to reduce urinary GAG excretion; and high levels (>or=50% of normal) rescued abnormalities of the long bones and motor activity. These data will be instrumental to design appropriate clinical protocols based on either enzyme or gene replacement therapy for MPS and to predict their impact on the pathological features of MPS.

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“…[4][5][6] It has been previously reported that CsA and nifedipine medication affect numbers of Langerhans cells 7 and macrophages 8,9 in overgrown gingiva and may play roles in qualitative changes in inflammatory response. Dihydropyridines are calcium-channel blocking agents often taken by patients with cardiovascular disorders and undergoing organ transplantation.…”

mentioning

confidence: 99%

Mast Cell Subpopulations in Gingival Overgrowth Induced by Immunosuppressive and Nifedipine Medication

Nurmenniemi

Pernu

Knuuttila

2004

Journal of Periodontology

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Macrophages and Lymphocyte Subpopulations in Nifedipine‐ and Cyclosporin A‐Associated Human Gingival Overgrowth

Abstract: The results support the idea that immune response may be altered in drug-induced gingival overgrowth.

Cited by 28 publications

References 29 publications

Potentiation of T Cell Function by a Marine Algae-Derived Sulfated Polymannuroguluronate: In Vitro Analysis of Novel Mechanisms

Potentiation of T Cell Function by a Marine Algae-Derived Sulfated Polymannuroguluronate: In Vitro Analysis of Novel Mechanisms

Different Serum Enzyme Levels Are Required to Rescue the Various Systemic Features of the Mucopolysaccharidoses

Mast Cell Subpopulations in Gingival Overgrowth Induced by Immunosuppressive and Nifedipine Medication

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