Macrophages and lymphocytes: Alternative sources of histamine

Zwadlo-Klarwasser, Gabriele; Braam, U.; Mühl-Zürbes, Petra; Schmutzler, W.

doi:10.1007/bf02007785

Cited by 44 publications

(35 citation statements)

References 8 publications

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“…The C48/80 has been used to produce experimental anaphylactic shock 18,22 . Our data showed that this compound was effective in inducing anaphylactic shock in pigs since both MAP and CO decreased after C48/80 administration.…”

Section: Discussionmentioning

confidence: 99%

Methylene blue administration in the compound 48/80-induced anaphylactic shock: hemodynamic study in pigs

Menardi¹,

Capellini²,

Celotto³

et al. 2011

Acta Cir. Bras.

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PURPOSE: To verify if the methylene blue (MB) administration prevents and/or reverses the compound 48/80 (C48/80)-induced anaphylactic shock in pigs. METHODS: Female Dalland pigs were anesthetized and had the hemodynamic parameters recorded during the necessary time to administer some drugs and observe their effect. The animals were randomly assigned to one of the five groups: 1) control; 2) MB: the animals received a bolus injection of MB (2 mg/kg) followed by continuous infusion of MB (2.66 mg/Kg/h delivered by syringe infusion pump); 3) C48/80: the animals received a bolus injection of C48/80 (4 mg/kg); 4) C48/80+MB: the animals received a bolus injection of C48/80 (4 mg/kg) and 10 minutes after the C48/80 administration the animals received a bolus injection of MB (2 mg/kg) followed by continuous infusion of MB (2.66 mg/Kg/h delivered by syringe infusion pump); 5) MB+C48/80: the animals received a bolus injection of MB (2 mg/kg) and 3 minutes later they received a bolus injection of C48/80 (4 mg/kg). RESULTS: The intravenous infusion of MB alone caused no changes in the mean arterial pressure (MAP) showing that the administered MB dose was safe in this experimental model. The C48/80 was effective in producing experimental anaphylactic shock since it was observed a decrease in both MAP and cardiac output (CO) after its administration. The MB did not prevent or reverse the C48/80-induced anaphylactic shock in this model. In fact, the MAP of the animals with anaphylactic shock treated with MB decreased even more than the MAP of the animals from the C48/80 group. On the other hand, the C48/80-induced epidermal alterations disappeared after the MB infusion. CONCLUSION: Despite our data, the clinical manifestations improvement brings some optimism and does not allow excluding the MB as a possible therapeutic option in the anaphylactic shock.

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Section: Discussionmentioning

confidence: 99%

Methylene blue administration in the compound 48/80-induced anaphylactic shock: hemodynamic study in pigs

Menardi¹,

Capellini²,

Celotto³

et al. 2011

Acta Cir. Bras.

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“…Both mast cells and MØ can produce and release histamine (59)(60)(61). However, relatively large numbers of mast cells are present in the peritoneum (2-5% of total cells) (23), and peritoneal mast cells may contain 2-10 picograms of histamine per cell (62).…”

Section: Implanted Biomaterials Trigger the Release Of Histaminementioning

confidence: 99%

“…However, relatively large numbers of mast cells are present in the peritoneum (2-5% of total cells) (23), and peritoneal mast cells may contain 2-10 picograms of histamine per cell (62). On the other hand, MØ only contain small amounts of histamine (about 0.5% of the histamine stored in mast cells) (35,61,63). Therefore, mast FIG.…”

Section: Implanted Biomaterials Trigger the Release Of Histaminementioning

confidence: 99%

“…Both mast cells and MØ may produce and release histamine (59)(60)(61). However, the peritoneal space contains relatively large numbers of mast cells (2-5% of total lavage cells) (23,76).…”

mentioning

confidence: 99%

“…However, the peritoneal space contains relatively large numbers of mast cells (2-5% of total lavage cells) (23,76). Furthermore, MØ can only release small amounts of histamine (about 0.5% of the amount of histamine that can be released by mast cells on a per-cell basis) (35,61,63). Therefore, we suspected that mast cells might be primarily responsible for the release of histamine and subsequent triggering of the recruitment of inflammatory cells to implant sites.…”

mentioning

confidence: 99%

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Mast cells mediate acute inflammatory responses to implanted biomaterials

Tang

Jennings

Eaton

1998

Proc. Natl. Acad. Sci. U.S.A.

250

185

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Implanted biomaterials trigger acute and chronic inf lammatory responses. The mechanisms involved in such acute inf lammatory responses can be arbitrarily divided into phagocyte transmigration, chemotaxis, and adhesion to implant surfaces. We earlier observed that two chemokinesmacrophage inf lammatory protein 1␣͞monocyte chemoattractant protein 1-and the phagocyte integrin Mac-1 (CD11b͞CD18)͞surface fibrinogen interaction are, respectively, required for phagocyte chemotaxis and adherence to biomaterial surfaces. However, it is still not clear

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Point‐of‐Care Health Diagnostics and Food Quality Monitoring by Molecularly Imprinted Polymers‐Based Histamine Sensors

Ahmed,

Ansari,

et al. 2024

Advanced Sensor Research

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Histamine, a biogenic amine (BA), plays a significant role in various pathophysiological processes and is present in food supplies, serving as an indicator of freshness and microbial degradation. It is a major cause of food poisoning outbreaks, triggering allergic inflammatory responses. Detecting histamine in food is crucial because its toxic threshold does not affect the food's taste, making contaminated items appear normal. To address this challenge, label‐free and bioactive‐free electrochemical sensors utilizing molecularly imprinted polymers (MIPs) offer the desired selectivity, scalability, and efficiency. MIPs are synthetic materials designed to mimic biological receptors. This paper reviews a decade of research on MIP‐assisted electrochemical sensors for histamine detection, focusing on their scalability, robustness, speed, and selectivity. The review critically analyzes the performance of these sensors in detecting histamine in food, beverages, human serum, and body diagnostics. Additionally, the current understanding of the physiological effects of endogenous and ingested histamine is reviewed, highlighting both established and emerging methods for its quantification in food and health management. The potential for transforming healthcare delivery through personalized Point‐of‐Care (POC) systems, integrated with Artificial Intelligence (AI) and Internet‐of‐Medical Things (IoMT) technologies, is also discussed.

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Macrophages and lymphocytes: Alternative sources of histamine

Cited by 44 publications

References 8 publications

Methylene blue administration in the compound 48/80-induced anaphylactic shock: hemodynamic study in pigs

Methylene blue administration in the compound 48/80-induced anaphylactic shock: hemodynamic study in pigs

Mast cells mediate acute inflammatory responses to implanted biomaterials

Point‐of‐Care Health Diagnostics and Food Quality Monitoring by Molecularly Imprinted Polymers‐Based Histamine Sensors

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