Macrophages Generate Pericytes in the Developing Brain

Prazeres, Pedro H. D. M.; Almeida, Viviani Mendes de; Lousado, Luiza; Andreotti, Julia P.; Paiva, Ana; Santos, Gabryella S P; Azevedo, Patrick O.; Souto, Luanny; Almeida, Gregório Guilherme; Filev, Renato; Mintz, Akiva; Gonçalves, Ricardo; Birbrair, Alexander

doi:10.1007/s10571-017-0549-2

Cited by 37 publications

(28 citation statements)

References 73 publications

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“…The hematopoietic stem cells, which give rise to all blood and immune cells throughout life, reside in a specific complex niche in the bone marrow, that supports the homeostasis of these cells, composed by osteoblasts, osteocytes, osteoclasts, endothelial cells, adipocytes, smooth muscle cells, pericytes, fibroblasts, macrophages, megakaryocytes, lymphocytes, hematopoietic progenitors, neutrophils, peripheral innervations, and Schwann cells [18,85,64,86–89,19,9,10,90,93]. Recent studies have revealed distinct contributions of several cellular components of the bone marrow to different functions of hematopoietic stem cells regulation.…”

Section: Perspectives / Future Directionsmentioning

confidence: 99%

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Azevedo

Paiva

Santos

et al. 2018

Cancer Metastasis Rev

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Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecF-expressing neutrophils supply to the tumor microenvironment. Interestingly, SiglecF neutrophil signature was associated with worse lung adenocarcinoma patients outcome. This study identifies novel cellular targets for lung cancer treatment. Here, we summarize and evaluate recent advances in our understanding of lung tumor microenvironment.

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Section: Perspectives / Future Directionsmentioning

confidence: 99%

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Azevedo

Paiva

Santos

et al. 2018

Cancer Metastasis Rev

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“…They communicate with endothelial cells along the length of the vasculature by physical contacts and paracrine signaling (Birbrair et al, ). In the central nervous system, the ratio of pericytes to endothelial cells is approximately 1:1 (Shepro & Morel, ), indicating the enormous importance of pericytes in the central nervous system physiology (Almeida et al, ; Birbrair et al, ; Coatti et al, ; Prazeres et al, ; Santos, Prazeres, Mintz, & Birbrair, ). Novel approaches which combine anatomical location with expression of multiple molecular markers, and with genetic lineage tracing became available recently, contributing to the progress in the understanding of pericytes function in health and disease (Birbrair et al, ).…”

Section: Introductionmentioning

confidence: 99%

Pericytes modulate myelination in the central nervous system

Azevedo

Sena

Andreotti

et al. 2018

Journal Cellular Physiology

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Multiple sclerosis is a highly prevalent chronic demyelinating disease of the central nervous system. Remyelination is the major therapeutic goal for this disorder. The lack of detailed knowledge about the cellular and molecular mechanisms involved in myelination restricts the design of effective treatments. De La Fuente et al. (2017) by using state-of-the-art techniques, including pericyte-deficient mice in combination with induced demyelination, reveal that pericytes participate in central nervous system regeneration. Strikingly, pericytes presence is essential for oligodendrocyte progenitors differentiation and myelin formation during remyelination in the brain. The emerging knowledge from this research will be important for the treatment of multiple sclerosis.

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“…31 Parfejevs et al exhibit that Schwann cells up-regulate the expression of PDGFβ after dermal lesion. 12 Interestingly, several stromal cells present in the skin microenvironment, important in wound healing progress, express the cell-surface tyrosine kinase receptor, PDGFRβ, such as pericytes, [32][33][34][35][36][37][38][39][40][41][42][43][44][45] vascular smooth muscle cells, 46,47 and tissue-resident fibroblasts. 48 Therefore, PDGFβ/PDGFRβ signaling may play crucial role in the communication between these important cell types during dermal healing.…”

Section: Schwann Cells Derived Signals Important After Cutaneous Injurymentioning

confidence: 99%

Role of Schwann cells in cutaneous wound healing

Silva

Leonel

Prazeres

et al. 2018

Wound Repair Regeneration

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Dermal wound healing is the process of repairing and remodeling skin following injury. Delayed or aberrant cutaneous healing poses a challenge for the health care system. The lack of detailed understanding of cellular and molecular mechanisms involved in this process hampers the development of effective targeted treatments. In a recent study, Parfejevs et al.-using state-of-the-art technologies, including in vivo sophisticated Cre/loxP techniques in combination with a mouse model of excisional cutaneous wounding-reveal that Schwann cells induce adult dermal wound healing. Strikingly, genetic ablation of Schwann cells delays wound contraction and closure, decreases myofibroblast formation, and impairs skin re-epithelization after injury. From a drug development perspective, Schwann cells are a new cellular candidate to be activated to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of Schwann cells roles in the skin microenvironment.

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Macrophages Generate Pericytes in the Developing Brain

Cited by 37 publications

References 73 publications

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Pericytes modulate myelination in the central nervous system

Role of Schwann cells in cutaneous wound healing

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