Macrophages in Renal Injury and Repair

Huen, Sarah C.; Cantley, Lloyd G.

doi:10.1146/annurev-physiol-022516-034219

Cited by 263 publications

(228 citation statements)

References 134 publications

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“…4A, the network of miRNAs and upregulated DEGs contained 17 nodes and 19 edges. Adamts1, Hspa2, Fn1 and Abcg1 had the highest degrees of 5, 3, 3 and 3, respectively. miR-142-5p was demonstrated to have an important role in regulating the highest number of upregulated DEGs, including Hspa2, Abcg1, Adamts1 and Tpbg.…”

Section: Potential Regulatory Mirnas Associated With Degsmentioning

confidence: 99%

“…Recently, AKI has been suggested to lead to long-term outcomes, including the development and progression of chronic kidney disease (CKD) and end-stage renal disease (ESRD), even in those patients who recover [2,3]. Although the needed to eliminate the short-and longterm outcomes of AKI is urgent, no effective therapy exists to prevent the development of these renal diseases.…”

Section: Introductionmentioning

confidence: 99%

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Bioinformatic Analyses of Renal Ischaemia-Reperfusion Injury Models: Identification of Key Genes Involved in the Development of Kidney Disease

Zhu

Zheng

Chen

et al. 2018

Kidney Blood Press Res

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Background/Aims: To develop a novel strategy for the treatment of kidney disease, we explored potential molecular targets involved in the development of renal ischaemia-reperfusion injury (IRI). Methods: The Gene expression profile data of GSE27274, including controls and rats subjected to renal IRI and reperfusion for 24 h (IR24) or 120 h (IR120), was obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were analysed using the limma package. Gene Ontology (GO) and pathway functional enrichment analyses of common DEGs were carried out. Protein-protein interactions (PPI) and miRNA-DEG network analyses were performed using the STRING database and WebGestalt, respectively, followed by network construction using Cytoscape. Results: In total, 80 common DEGs (41 up- and 39 downregulated genes) between IR24 and IR120 were screened. Genes encoding tissue inhibitor of matrix metalloproteinase-1 (Timp1), secreted phosphoprotein 1 (Spp1) and dimethylglycine dehydrogenase (Dmgdh) were identified as hub genes in the PPI network and may be significant in the development of renal IRI. Upregulated Spp1 was enriched in the inflammatory response, and downregulated Dmgdh was enriched in the catabolic process of the amino acid betaine. In reactome pathway analyses, Spp1 was enriched in toll-like receptor signalling, and Dmgdh was enriched in glycine, serine and threonine metabolic pathways. The common DEGs were mainly regulated by 15 miRNA clusters. Conclusion: Timp1, Spp1, Dmgdh, miR-142-5p and miR-181a may be potential targets or biomarkers for the development of renal IRI.

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Section: Potential Regulatory Mirnas Associated With Degsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioinformatic Analyses of Renal Ischaemia-Reperfusion Injury Models: Identification of Key Genes Involved in the Development of Kidney Disease

Zhu

Zheng

Chen

et al. 2018

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…42 HMGB1 can promote the inflammatory response and immune response to aggravate the organ IRI through the TLR4 signalling pathway [43][44][45] ; TLR4 is mainly expressed on DCs, macrophages and other cells, so we can hypothe- at later time points, macrophages are required for tubular proliferation during normal repair. 46 The effect of DCs is related to its maturity, activation degree and quantity. 28 Dendritic cells not only participates in the inflammatory response after ischaemia, but also affects the healing reaction of IRI.…”

Section: Damage-associated Molecular Patterns Can Stimulate Dcs Tomentioning

confidence: 99%

The role of dendritic cells regulated by HMGB1/TLR4 signalling pathway in myocardial ischaemia reperfusion injury

Xue

Lin

et al. 2019

J Cellular Molecular Medi

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Inflammatory response plays an important role in ischaemia reperfusion injury (IRI) through a variety of inflammatory cells. Apart from neutrophils, macrophages and lymphocytes, the role of dendritic cells (DCs) in IRI has been noticed. The study was aimed at investigating whether the high‐mobility group protein box‐1/toll like receptor 4 (HMGB1/TLR4) signalling pathway regulate the migration, adhesion and aggregation of DCs to the myocardium, induce DCs activation and maturation, stimulate the expression of surface costimulatory molecules and participate in myocardial IRI. In vivo, migration, adhesion, and aggregation of DCs was enhanced; the expression of peripheral blood DCs CD80 and CD86, myocardial adhesion molecules were increased; and the infarct size was increased during myocardial ischaemia reperfusion injury myocardial ischemic/reperfusion injury (MI/RI). These responses induced by MI/RI were significantly inhibited by HMGB1 specific neutralizing antibody treatment. Cellular experiments confirmed that HMGB1 promoted the release of inflammatory cytokines through TLR4/MyD88/NF‐κB, upregulated CD80 and CD86 expression, mediated the damage of cardiomyocytes and accelerated the apoptosis. Our results indicate that DCs activation and maturation, stimulate the expression of surface costimulatory molecules by promoting the release of inflammatory factors through NF‐κB pathway and participate in myocardial IRI.

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“…During tissue injury, monocytes can enter tissues from the peripheral blood and can further differentiate into inflammatory macrophages and reparative/resolving macrophages in situ 55,56,57 . If the cells are chronically exposed to damage-associated molecular pattern molecules (DAMPs) and endosomal TLR ligands, resolution may fail, and macrophages with mixed functions may emerge 58 .…”

Section: Cc-by-nc-nd 40 International License It Is Made Available Umentioning

confidence: 99%

The immune cell landscape in kidneys of lupus nephritis patients

Arazi

Rao

Berthier

et al. 2018

Preprint

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Lupus nephritis is a potentially fatal autoimmune disease, whose current treatment is ineffective and often toxic. To gain insights into disease mechanisms, we analyzed kidney samples from lupus nephritis patients and healthy controls using single-cell RNA-seq. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid, T, NK and B cells, demonstrating both pro-inflammatory and resolving responses. We found evidence of local activation of B cells correlated with an age-associated B cell signature, and of progressive stages of monocyte differentiation within the kidney. A clear interferon response was observed in most cells. Two chemokine receptors, CXCR4 and CX3CR1, were broadly expressed, pointing to potential therapeutic targets. Gene expression of immune cells in urine and kidney was highly correlated, suggesting urine may be a surrogate for kidney biopsies. Our results provide a first comprehensive view of the complex network of leukocytes active in lupus nephritis kidneys.

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Macrophages in Renal Injury and Repair

Cited by 263 publications

References 134 publications

Bioinformatic Analyses of Renal Ischaemia-Reperfusion Injury Models: Identification of Key Genes Involved in the Development of Kidney Disease

Bioinformatic Analyses of Renal Ischaemia-Reperfusion Injury Models: Identification of Key Genes Involved in the Development of Kidney Disease

The role of dendritic cells regulated by HMGB1/TLR4 signalling pathway in myocardial ischaemia reperfusion injury

The immune cell landscape in kidneys of lupus nephritis patients

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