Macrophages induce antibody-dependent cytostasis but not lysis in guinea pig leukaemic cells

Lawson, A D; Stevenson, G T

doi:10.1038/bjc.1983.178

Cited by 8 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After this "modulation", cytotoxicity reduces, on the average, by a factor 10 (cytotoxicity drops maximally from 28% to 0%) (13 (12) show that (tumor) cells with a n antigen density too low for efficient lysis by AB and complement remain sensitive to cell-mediated lysis. In addition, macrophage cytostatic activity remains unaffected after modulation, whereas lysis by complement reduces (18). In our model, we opt for a 50-fold reduction in susceptibility to cell-mediated cytotoxicity.…”

Section: Methodsmentioning

confidence: 99%

Interactions between macrophages and T-lymphocytes: Tumor sneaking through intrinsic to helper T cell dynamics

Boer

Hogeweg

1986

Journal of Theoretical Biology

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Interactions between macrophages and T-lymphocytes: Tumor sneaking through intrinsic to helper T cell dynamics

Boer

Hogeweg

1986

Journal of Theoretical Biology

View full text Add to dashboard Cite

“…However, cytolysis was detected only at the lower E:T ratio tested (3 : 1); at the higher E : T ratio (20 : 1) there was only a noncytolytic cytostasis. Such noncytolytic cytostasis has been demonstrated previously [1,18].…”

Section: Discussionmentioning

confidence: 69%

Further studies on the differences in cytotoxicity of human peripheral blood monocytes and bronchoalveolar macrophages for cultured human lung cells

Swinburne

Moore

Cole

1985

Cancer Immunol Immunother

View full text Add to dashboard Cite

Previously reported differences between the cytostatic activity of human peripheral blood monocytes (PBM) and bronchoalveolar macrophages (BAM) for cultured human lung tumor cells have been further investigated. The differences are both quantitative and qualitative and are shown not to be due to the respective methods of purification. There was a varying contribution of cytolysis to the cytostasis detected by the 75selenomethionine post-labeling assay used. Bronchoalveolar macrophages were cytolytic when tested at both low and high E:T ratios but PBM were only cytolytic at the low E:T ratio. A variable dependence upon soluble cytostatic factor(s) was suggested, and there was evidence of heterogeneity in the factors released by the two populations. Cytostatic factor production by both populations appeared to be under similar regulatory constraints. In vitro maturation of PBM altered their cytostatic dose-response curve to one resembling that previously reported for BAM. It was also shown that sera from poor-prognosis lung tumor patients, which suppressed the in vitro maturation of PBM, also suppressed the in vitro cytostatic activity of PBM for cultured human lung tumor cells.

show abstract

“…Although K cells, NK cells and macrophages are known to attack antibody-coated cells in vitro (e.g. Ojo & Wigzell, 1978;Kumagai et al, 1981;Lawson & Stevenson, 1983) it is difficult to extrapolate these findings to environments in vivo. Lacking such precise knowledge makes it difficult to select antibody isotypes, and we have accordingly included in Table III the heading inadequate or inappropriate recruitment of effectors.…”

Section: Discussionmentioning

confidence: 96%

“…Linscott, 1970;Lesley et al, 1974;Gordon et al, 1982). Cell-mediated lysis (Lesley et al, 1974) or cytostasis (Lawson & Stevenson, 1983) does not appear so susceptible. Results in the present study, particularly the better complement killing observed for CW cells, are consistent with surface antigen density having a significant role in determining the susceptibility of cells to killing by antibody in the vascular compartment.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of tumour cell escape encountered in treating lymphocytic leukaemia with anti-idiotypic antibody

Gordon¹,

Abdul-Ahad²,

Hamblin³

et al. 1984

Br J Cancer

Self Cite

View full text Add to dashboard Cite

Macrophages induce antibody-dependent cytostasis but not lysis in guinea pig leukaemic cells

Cited by 8 publications

References 24 publications

Interactions between macrophages and T-lymphocytes: Tumor sneaking through intrinsic to helper T cell dynamics

Interactions between macrophages and T-lymphocytes: Tumor sneaking through intrinsic to helper T cell dynamics

Further studies on the differences in cytotoxicity of human peripheral blood monocytes and bronchoalveolar macrophages for cultured human lung cells

Mechanisms of tumour cell escape encountered in treating lymphocytic leukaemia with anti-idiotypic antibody

Contact Info

Product

Resources

About