2013
DOI: 10.1159/000356293
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Macrophages: Past, Present and Future

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Cited by 8 publications
(5 citation statements)
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“…Macrophages are a diverse and important component of the innate immune system, with versatile functions in host defence and immunity. They are the frontline of defence against foreign microorganisms, including bacteria, parasites, and viruses 1 3 . During infection, the inflammatory response of macrophages comprises four stages: recognition of infection by pattern-recognition receptors (PRRs), recruitment of macrophages to infected tissue, elimination of pathogens, and restoration of tissue homeostasis.…”
Section: Introductionmentioning
confidence: 99%
“…Macrophages are a diverse and important component of the innate immune system, with versatile functions in host defence and immunity. They are the frontline of defence against foreign microorganisms, including bacteria, parasites, and viruses 1 3 . During infection, the inflammatory response of macrophages comprises four stages: recognition of infection by pattern-recognition receptors (PRRs), recruitment of macrophages to infected tissue, elimination of pathogens, and restoration of tissue homeostasis.…”
Section: Introductionmentioning
confidence: 99%
“…Non-TLR, including the family of scavenger receptors [166] and the C-type lectins [167], are involved in phagocytosis and endocytosis. Opsonic receptors include complement receptors (integrins, such as CD11b) and Fc receptors (immunoglobulin superfamily, such as CD44), which dominate the phagocytosis and endocytosis of complement-or antibody-opsonised particles, respectively [168]. Those phagocytosis-related receptors are, thus, ideal structures for a macrophage-targeting therapy, which can facilitate nano-carriers to deliver therapeutic agents into macrophages selectively.…”
Section: Phagocytosis-related Cell Membrane Receptors Targetingmentioning
confidence: 99%
“…Recently, increasing attention has been paid to tumor immunosurveillance in the prevention and treatment of tumors 7 , 8 . In particular, macrophages, the most infiltrating immune cells in tumor tissues, can recognize and phagocytose tumor cells through non-specific immunity 9 , followed by T cell-mediated specific immunity, which involves the degradation of tumor cells and the expression of major histocompatibility complex classes I and II on the cell surface 10 , 11 . It is worth to note that a large number of macrophages are required to phagocyte apoptotic tumor cells timely during radiotherapy or chemotherapy, which is critical in promoting the therapeutic effect 12 .…”
Section: Introductionmentioning
confidence: 99%