Macrophomina phaseolina: microbased biorefinery for gold nanoparticle production

Sreedharan, Smitha Mony; Gupta, Sonali; Saxena, Anil Kumar; Singh, Rajni

doi:10.1007/s13213-018-1434-z

Cited by 25 publications

(8 citation statements)

References 76 publications

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“…In the next step, the enzymes such as sulfate reductase, sulfite reductase or nitrate reductase carry out the detoxification of the metal by reducing it into metal atoms that aggregate to form NMs. Results documented by Sreedharan et al [34] supports the above-mentioned mechanism for the production of Au NMs by Macrophomina phaseolina.…”

Section: Microorganisms Based Nmssupporting

confidence: 60%

Green Chemistry: Evolution in Architecting Schemes for Perfecting the Synthesis Methodology of the Functionalized Nanomaterials

et al. 2021

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Recently, significant attention and effort have been given to the synthesis of nanomaterials (NMs) by utilizing numerous conventional and advanced methodologies owing to its various applications in different fields of life. The green methodology is preferred over other approaches because of the advantages of cost-effectiveness, environment friendliness, and non-toxic nature of the utilized biogenic materials. This review summarizes and organizes the documented case studies presented in the last five years i. e. 2017-2021 that use the green chemistry approach for the production of NMs into the two broad categories of plant based NMs and microorganisms based NMs.Furthermore, the fundamentals involved in this production process such as optimization of the synthetic process, mechanism involved in the production of NMs owing to the selected biogenic system, and the extraction techniques utilized for the synthesis of the plant/biogenic extracts are also discussed in detail in this review. We believe that this review will highlight some critical practices and advancements which must be taken into consideration beforehand by the new/working scholars exploring the field of green chemistry for the production of NMs.

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Section: Microorganisms Based Nmssupporting

confidence: 60%

Green Chemistry: Evolution in Architecting Schemes for Perfecting the Synthesis Methodology of the Functionalized Nanomaterials

et al. 2021

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“…The uptake of negatively charged particles despite the unfavorable interaction between the particles and the negatively charged cell membrane has been reported in the literature 3. Neutral and negatively charged nanoparticles have reported to show lower levels of internalization as compared to the positively charged particles due to their lesser adsorption onto the negatively charged cell-membrane surface.…”

Section: Resultsmentioning

confidence: 92%

“…The ability of these particles to form conjugates with many functional agents such as drugs, dendrimers, ligands, DNA, proteins and RNA enhances their utilization in drug targeting for the cure against cancers, neurological disorders, gene therapy, HIV and many other diseases 2. Especially the biological nanoparticles have protein capping on it with a large number of functional groups which aids in the conjugation of gold nanoparticles with a number of biomolecules and chemical drug to develop a nanoparticles-based drug delivery system 3. Over the years, gold nanoparticles particularly are of great interest due to their various attributes such as biocompatibility, small size, well-developed surface chemistry and stability.…”

Section: Introductionmentioning

confidence: 99%

<p>Ciprofloxacin Functionalized Biogenic Gold Nanoflowers as Nanoantibiotics Against Pathogenic Bacterial Strains</p>

Sreedharan

Singh

2019

IJN

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PurposeAntibiotics are currently being rendered non-functional by the rising incidence of multi-drug resistance amongst pathogenic bacteria. Research has now been focused on developing solutions to this problem by creating new antibiotics and enhancing the functionality of the existing ones.Patients and methodsIn the present study, ciprofloxacin was conjugated to biogenic gold nanoflowers (GNFs) from Bacillus subtilis RSB64 by a robust adsorption method under optimized conditions. The resultant drug–nanoflower conjugate was characterized by UV–visible spectroscopy and Fourier transform infrared spectroscopy (FTIR). Addition of ciprofloxacin to gold nanoflowers changed the extinction spectrum towards longer wavelength. The ciprofloxacin-conjugated gold nanoflowers were tested for the drug release statistically. The prepared nanoflower–drug conjugate was subjected to an in vitro microbiological assay against different Gram-positive and Gram-negative bacterial strains to verify the effect of GNF–ciprofloxacin conjugate on the cell growth inhibitory activity of ciprofloxacin.ResultsThe GNF–ciprofloxacin conjugates demonstrated enhanced bactericidal activity against Gram-negative bacteria as compared to Gram-positive. The enhancement of the antibacterial activity of the nanoflower–drug conjugate could be attributed to the interaction of the conjugate with phosphate/amine group of the outer membrane of Gram-negative bacterial cell wall making them susceptible to the antibacterial effect of the conjugate.ConclusionThis study demonstrates the positive attributes of GNF–ciprofloxacin conjugates as a promising antibacterial therapeutic agent against pathogens.

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“…Different size and shape GNPs have been used by many researchers in diverse biomedical applications. 92,98,99 As discussed in other sections of this review, radioactive and simple gold nanostructures have been used in many advanced biomedical applications. 100 Alkilany and co-workers studied the toxicity of colloidal GNPs.…”

Section: Biological Properties Of Gold Nanoparticles: Toxicity Aspectmentioning

confidence: 99%

Role of gold nanoparticles in advanced biomedical applications

et al. 2020

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Macrophomina phaseolina: microbased biorefinery for gold nanoparticle production

Cited by 25 publications

References 76 publications

Green Chemistry: Evolution in Architecting Schemes for Perfecting the Synthesis Methodology of the Functionalized Nanomaterials

Green Chemistry: Evolution in Architecting Schemes for Perfecting the Synthesis Methodology of the Functionalized Nanomaterials

<p>Ciprofloxacin Functionalized Biogenic Gold Nanoflowers as Nanoantibiotics Against Pathogenic Bacterial Strains</p>

Role of gold nanoparticles in advanced biomedical applications

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