Macroporous biphasic calcium phosphate scaffolds reinforced by poly-L-lactic acid/hydroxyapatite nanocomposite coatings for bone regeneration

Nie, Lei; Chen, Dong; Fu, Jun; Yang, Shuai; Hou, Ruixia; Suo, Jinping

doi:10.1016/j.bej.2015.02.026

Cited by 58 publications

(32 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The compressive strength of nanocomposite was an important criterion for bone tissue engineering application, and the compressive strength of the spongy bone was in range of 0.2-4 MPa according to previous reports [45][46][47]. Figure 5c, d showed that the compressive strengths of prepared GA and DT-GA nanocomposites were in the range of 1-2 MPa.…”

Section: Compressive Strengths Of Ga and Dt-ga Nanocompositessupporting

confidence: 63%

“…It was well known that the interconnected structure of nanocomposite as scaffold played a critical role in bone tissue engineering. The porous nanocomposite could provide a template for cell attachment and proliferation, and the porous structure was beneficial for the mass and nutrient transport, as well as supporting newly formed tissue [45,46,51]. Figures 3 and 4 showed typical interconnected porous structures for prepared GA and DT-GA nanocomposites.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and characterization of dithiol-modified graphene oxide nanosheets reinforced alginate nanocomposite as bone scaffold

et al. 2019

Self Cite

View full text Add to dashboard Cite

Porous graphene oxide (GO) nanocomposite as scaffold has attracted increasing attention in bone tissue engineering recently. In this study, GO nanosheets was modified by 2,2′-(ethylenedioxy)-diethnethiol (EDDET), and dithiol-modified GO (DT-GO) nanosheets were obtained. The results confirmed that GO nanosheets were cross-linked by EDDET, meanwhile, the distance between GO layers reduced after modification. Next, DT-GO nanosheets were further incorporated into alginate hydrogels to fabricate DT-GO/alginate (DT-GA) nanocomposite as scaffold. The prepared DT-GA nanocomposite behaved the laminar network morphology with interconnected porous structure confirmed by SEM analysis. In addition, the DT-GA nanocomposite with the concentration of DT-GO nanosheets at 16.7% showed the highest porosity value and lowest compressive strength. Furthermore, the bone marrow derived mesenchymal stem cells (BMSCs) showed a good proliferation on DT-GA nanocomposite, demonstrated that prepared nanocomposite had a good cytocompatibility, which was identified by CCK-8 assay and fluorescent microscopy images. Lastly, ALP activity analysis certified that BMSCs seeded on DT-GA nanocomposite could differentiate into osteoblastic phenotype. Above results suggest that the dithiol-modified GO/alginate nanocomposite has the potential to be applied in bone tissue engineering.

show abstract

Section: Compressive Strengths Of Ga and Dt-ga Nanocompositessupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Preparation and characterization of dithiol-modified graphene oxide nanosheets reinforced alginate nanocomposite as bone scaffold

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…These show bioactivity, bioresorbablilty, and similar composition of the mineral part of the natural bone and extensively used in tissue engineering applications, especially bone tissue regeneration [243,244]. Also, recently magnesium phosphates (MgP) have attracted great attention as an alternative to CaP due to their similar biodegradability and biocompatibility as well as excellent mechanical properties [245,246].…”

Section: Pva-bioceramics-based Hydrogelsmentioning

confidence: 99%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

385

161

View full text Add to dashboard Cite

Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed. GRAPHICAL ABSTRACTDownloaded by [University of Sussex Library] at 08:36 28 June 2016 2

show abstract

“…It was also shown that the injectable hydrogel composited with the delivery system has the potential for treating early-stage osteonecrosis of the femoral head, and such an injection treatment performed many advantages compared to traditional engineered scaffold replacement, including surgical convenience, and lower side effects, etc. [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Composite Hydrogels with the Simultaneous Release of VEGF and MCP-1 for Enhancing Angiogenesis for Bone Tissue Engineering Applications

Chang¹,

Sun

Huo

et al. 2018

Applied Sciences

Self Cite

View full text Add to dashboard Cite

Rapid new microvascular network induction was critical for bone regeneration, which required the spatiotemporal delivery of growth factors and transplantation of endothelial cells. In this study, the linear poly(d,l-lactic-co-glycolic acid)-b-methoxy poly(ethylene glycol) (PLGA-mPEG) block copolymer microspheres were prepared for simultaneously delivering vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1). Then, vascular endothelial cells (VECs) with growth factor loaded microspheres were composited into a star-shaped PLGA-mPEG block copolymer solution. After this, composite hydrogel (microspheres ratio: 5 wt%) was formed by increasing the temperature to 37 °C. The release profiles of VEGF and MCP-1 from composite hydrogels in 30 days were investigated to confirm the different simultaneous delivery systems. The VECs exhibited a good proliferation in the composite hydrogels, which proved that the composite hydrogels had a good cytocompatibility. Furthermore, in vivo animal experiments showed that the vessel density and the mean vessel diameters increased over weeks after the composite hydrogels were implanted into the necrosis site of the rabbit femoral head. The above results suggested that the VECs-laden hydrogel composited with the dual-growth factor simultaneous release system has the potential to enhance angiogenesis in bone tissue engineering.

show abstract

Macroporous biphasic calcium phosphate scaffolds reinforced by poly-L-lactic acid/hydroxyapatite nanocomposite coatings for bone regeneration

Cited by 58 publications

References 54 publications

Preparation and characterization of dithiol-modified graphene oxide nanosheets reinforced alginate nanocomposite as bone scaffold

Preparation and characterization of dithiol-modified graphene oxide nanosheets reinforced alginate nanocomposite as bone scaffold

PVA-based hydrogels for tissue engineering: A review

Composite Hydrogels with the Simultaneous Release of VEGF and MCP-1 for Enhancing Angiogenesis for Bone Tissue Engineering Applications

Contact Info

Product

Resources

About