Macroporous polyacrylamide hydrogels with tailored porosity and mechanical properties via microphase separation in the presence of hydroxyethylcellulose

Abstract

In this work hydroxyethylcellulose (HEC) was employed to prepare macroporous polyacrylamide (PAAm) hydrogels with different porosities and degrees of interconnectivity. The porosity and the equilibrium mass swelling ratio of hydrogels equilibrated in 0.1 M NaCl increased with the amount of HEC employed in the reaction mixture. Tensile and fracture tests were performed to investigate the mechanical behavior of both as prepared hydrogels and of hydrogels equilibrated in 0.1 M NaCl. As prepared hydrogels displayed invariably better mechanical properties than the corresponding equilibrated hydrogels. The mechanical stiffness decreased regularly as the amount of HEC (and porosity) was increased. A more complex trend was observed for the ultimate properties (elongation and stress at break) and for the fracture resistance, which displayed a maximum at intermediate HEC contents. POLYM. ENG. SCI., 57:764–771, 2017. © 2017 Society of Plastics Engineers

Novel Natrosol/Pectin-co-poly (acrylate) based pH-responsive polymeric carrier system for controlled delivery of Tapentadol Hydrochloride

“…For instance, Yoshinobu et al (1992) found that increasing the cross-linker content in cellulosic hydrogels decreased the porosity percentage, similar to our findings. Bignotti et al (2017) also observed that an increase in Natrosol content increased the porosity of HEC and polyacrylamide-based hydrogels, supporting our results. Likewise, Bashir et al (2020) reported that increasing the amount of Pectin and Acrylic Acid in HPMC-Pectin-Acrylic Acid co-polymerized hydrogels increased the porosity proportionally, consistent with our observations.…”

Hydrophilic shape memory polymer hydrogels with virous pore structures and shape changing performance

“…Figure 3B showed the increase in porosity (71.87%–84.34%) of the hydrogel with an increasing mass fraction of PPG. In general, the mechanical stiffness decreased regularly as the porosity was increased 29,30 . The hydrogels we prepared also conform to this law.…”

“…In general, the mechanical stiffness decreased regularly as the porosity was increased. 29,30 The hydrogels we prepared also conform to this law. The compressive strength of the solid-state hydrogel gradually decreased from 3.88 to 0.44 MPa.…”

Polyacrylamide hydrogels prepared by varying water content during polymerization: Material characterization, reswelling ability, and aging resistance

“…An addition of a hydrophilic agent into the reaction mixture during polymerization is another way how to prepare microporous hydrogels. For example, Bignotti et al [43] used hydroxyethylcellulose for this purpose and prepared PAAm hydrogels with the porosity ranging from 24% to 45%.…”