Macroscale Cortical Organization and a Default-Like Transmodal Apex Network in the Marmoset Monkey

Buckner, Randy L.; Margulies, Daniel S.

doi:10.1101/415141

Cited by 30 publications

(48 citation statements)

References 76 publications

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“…2a). Areas of the putative default mode network (DMN), including those in the posterior parietal cortex (PGM, PG, OPt, AIP), posterior cingulate cortex (A23a, A23b) and dorsolateral prefrontal cortex (A8aD, A6DR) lie in the core structure, but not those in the medial prefrontal cortex (A24d, A32, A32V), reflecting recent studies in the marmoset 23,24 .…”

Section: The Connectome Is Dense Heterogeneous and Has High Specifimentioning

confidence: 86%

Structural attributes and principles of the neocortical connectome in the marmoset monkey

Theodoni

Majka

Reser

et al. 2020

Preprint

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The marmoset monkey has become an important primate model in Neuroscience. Here we characterize salient statistical properties of inter-areal connections of the marmoset cerebral cortex, using data from retrograde tracer injections. We found that the connectivity weights are highly heterogeneous, spanning five orders of magnitude, and are log-normally distributed. The corticocortical network is dense, heterogeneous and has high specificity. The reciprocal connections are the most prominent and the probability of connection between two areas decays with their functional dissimilarity. The laminar dependence of connections defines a hierarchical network correlated with microstructural properties of each area. The marmoset connectome reveals parallel streams associated with different sensory systems. Finally, the connectome is spatially embedded with a characteristic length that obeys a power law as a function of brain volume across species. These findings provide a connectomic basis for investigations of multiple interacting areas in a complex large-scale cortical system underlying cognitive processes.

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Section: The Connectome Is Dense Heterogeneous and Has High Specifimentioning

confidence: 86%

Structural attributes and principles of the neocortical connectome in the marmoset monkey

Theodoni

Majka

Reser

et al. 2020

Preprint

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“…Components of the fronto-parietal network have been shown to guide behaviour in an adaptive manner, changing in line with external demands [29], and possibly substantiated by its ability to dynamically reconfigure its functional connectivity [95]. Although the functional role of the default mode network as the putative apex of the cortical functional hierarchy in primates remains subject to debate [96], it is evidently involved a broad class of memory-driven operations, involving self-referential and simulative thought processes and some degree of abstraction [32][33][34]. The interesting possibility that reduced hierarchical constraints enable functional diversity and flexibility was also supported by ad hoc metaanalysis, suggesting that microstructural and functional gradients decouple in regions contributing to processes such as working memory, social cognition, and cognitive control.…”

Section: Discussionmentioning

confidence: 99%

Microstructural and Functional Gradients are Increasingly Dissociated in Transmodal Cortices

Paquola

Wael

Wagstyl

et al. 2018

Preprint

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291

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While the role of cortical microstructure in organising neural function is well established, it remains unclear how structural constraints can give rise to more flexible elements of cognition. While nonhuman primate research has demonstrated a close structure-function correspondence, the relationship between microstructure and function remains poorly understood in humans, in part because of the reliance on post mortem analyses which cannot be directly related to functional data. To overcome this barrier, we developed a novel approach to model the similarity of microstructural profiles sampled in the direction of cortical columns. Our approach was initially formulated based on an ultra-highresolution 3D histological reconstruction of an entire human brain and then translated to myelinsensitive MRI data in a large cohort of healthy adults. This novel method identified a system-level gradient of microstructural differentiation traversing from primary sensory to limbic regions that followed shifts in laminar differentiation and cytoarchitectural complexity. Importantly, while microstructural and functional gradients described a similar hierarchy, they became increasingly dissociated in transmodal default mode and fronto-parietal networks. Meta analytic decoding of these topographic dissociations highlighted involvement in higher-level aspects of cognition such as cognitive control and social cognition. Our findings demonstrate a relative decoupling of macroscale functional from microstructural gradients in transmodal regions, which likely contributes to the flexible role these regions play in human cognition.

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“…Interestingly, the thalamus and the basal forebrain are phylogenetically older than many cortical structures and especially those that compose the DMN (Butler, 2008;Karten, 2015;Yamamoto et al, 2017). The inclusion of these structures in the anatomical model of the DMN can open a window to the exploration of DMN in other mammalian species as well (Buckner and Margulies, 2018;Lu et al, 2012;Rilling et al, 2007;Vincent et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Subcortical Anatomy of the Default Mode Network: a functional and structural connectivity study

Alves¹,

Foulon

Karolis

et al. 2019

Preprint

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Most existing research into the default-mode network (DMN) has taken a corticocentric approach. Despite the resemblance of the DMN with the unitary model of the limbic system, the anatomy and contribution of subcortical structures to the network may be underappreciated due to methods limitation. Here, we propose a new and more comprehensive neuroanatomical model of the DMN including the basal forebrain and anterior and mediodorsal thalamic nuclei and cholinergic nuclei. This has been achieved by considering functional territories during interindividual brain alignment. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity of the DMN and revealed that the thalamus and basal forebrain had high importance in term of values of node degree and centrality in the network. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brain and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.

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Macroscale Cortical Organization and a Default-Like Transmodal Apex Network in the Marmoset Monkey

Cited by 30 publications

References 76 publications

Structural attributes and principles of the neocortical connectome in the marmoset monkey

Structural attributes and principles of the neocortical connectome in the marmoset monkey

Microstructural and Functional Gradients are Increasingly Dissociated in Transmodal Cortices

Subcortical Anatomy of the Default Mode Network: a functional and structural connectivity study

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