Five flavonoids, including quercetin (1) and four its derivatives, quercitrin (2), isoquercitrin (3), astibin (4), and rutin (5), together with two phenolic glycosides, 3,3′‐di‐O‐methylellagic acid 4‐O‐β‐D‐xylopyranoside (6), and aesculin (7) were isolated from the whole plants of Macrosolen bidoupensis Tangane & V.S. Dang. Their chemical structures were characterized using HR‐ESI‐MS, NMR data and comparison with published data. Compounds (3, 4 & 7) were notified from the Macrosolen genus for the first time, whereas, all isolated compounds were informed for the first time from this species.