“…Today, thermodynamic theories play a crucial role in the understanding of several nano-systems and physical phenomena, including macromolecular folding and unfolding [48][49][50], molecular motors [51,52], muscles behavior [53,54], adhesion processes [55][56][57], micro-and nano-heat engines [58][59][60], micromagnetism [61][62][63][64][65], and heat transfer in nanostructures [66][67][68], just to name a few.…”