Macrovascular disease in a Japanese–Brazilian population of high prevalence of metabolic syndrome: Associations with classical and non-classical risk factors

Siqueira, Antonela F. A.; Franco, Laércio Joel; Gimeno, Suely G A; Matsumura, Luiza K.; Abdalla, Dulcinéia Saes Parra; Barros, Nilana M.T.; Ferreira, Sandra Roberta Gouvêa

doi:10.1016/j.atherosclerosis.2006.09.012

Cited by 14 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…26 Results published previously by our research team have shown that Japanese-Brazilians are a high-risk group, in terms of their figures for obesity, diabetes mellitus, arterial hypertension and dyslipidemia. [11][12][13]23 We detected significant associations between PAOD and two classical risk factors: smoking and arterial hypertension. Subjects with more advanced forms of the disease (ABI ≤0.70) had higher values for the (not classical) biomarkers investigated (CRP-us and IL-6).…”

Section: Discussionmentioning

confidence: 91%

“…[11][12][13]23 Although mean values and frequencies of risk factors among men were higher, the prevalence of PAOD was similar for both sexes. Similar figures for PAOD have been observed in other populations at high cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

“…Details of the umbrella study into the prevalence of diabetes and metabolic syndrome have been described elsewhere. [11][12][13] The study was approved by the Institutional Ethics Committee and free and informed consent forms were signed by all participants. A total of 1,330 people underwent a clinical examination, including anthropometric measurements, arterial blood pressure measurement and calculation of the Doppler ankle-brachial index (ABI).…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Biomarkers of inflammation may be of use for identification of more severe peripheral arterial occlusive disease

2014

View full text Add to dashboard Cite

Background: Atherosclerosis is a multifactorial disease with an inflammatory pathophysiological basis. Cytokines released during the atherosclerotic process induce production of C-reactive protein (CRP) in the liver, which is an important marker of inflammation. Objective: We tested whether inflammatory biomarkers were associated with deterioration of peripheral arterial occlusive disease (PAOD) in a population at high cardiovascular risk. Methods: 1,330 subjects ≥30 years of age underwent clinical and laboratory examinations as part of a population-based study of the prevalence of diabetes. PAOD was defined as an ankle-brachial index (ABI) ≤0.90. After application of exclusion criteria, the sample comprised 1,038 subjects. Traditional risk factors, CRP and interleukin 6 (IL-6) were also compared across three ABI categories (≤0.70; 0.71-0.90; ≥0.90). Mean values for these variables were compared by presence/absence of DAOP (Student' s t test) and by ABI categories (ANOVA). Poisson regression and logistic regression models were used to test for associations between risk factors and DAOP and between risk factors and the ABI categories. Pearson' s linear correlation coefficients were calculated for the relationship between CRP and IL-6 levels. Results: Mean age was 56.8±12.9 years, 54% of the sample were women and the prevalence of DAOP was 21.0% (95%CI 18.4-24.1). Individuals with ABI ≤0.70 had higher concentrations of CRP-us (2.1 vs. 1.8) and of IL-6 (1.25 vs. 1.17). Concentrations of CRP and IL-6 were only correlated in patients with DAOP, (p=0.004). Conclusions: The finding that CRP and IL-6 levels were only elevated among people with advanced DAOP may suggest that these biomarkers have a role to play as indicators of more severe disease. Prospective studies are needed to test this hypothesis.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Biomarkers of inflammation may be of use for identification of more severe peripheral arterial occlusive disease

2014

View full text Add to dashboard Cite

show abstract

“…Os 1.165 indiví-duos estudados foram classificados segundo presença de DMV, de acordo com o escore obtido a partir da condição de saúde, elaborado por Siqueira e cols. (1). O critério original classificava como ausência de DMV um escore de 0 a 1; como possível DMV (suspeito), um escore 2; e como DMV definida (doentes), escore ≥ 3.…”

Section: Presença De Dmvunclassified

Consumo alimentar e doença macrovascular em nipo-brasileiros: um estudo transversal

Salvo

Cardoso

Barros

et al. 2009

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

ResumoObjetivo: Descrever o hábito alimentar de nipo-brasileiros com e sem doença macrovascular (DMV). Métodos: Definiu-se DMV, para 1.165 nipo-brasileiros, a partir de escores atribuídos ao histórico de saúde, eletrocardiograma e valores do índice tornozelo-braquial. Determinou-se o consumo alimentar habitual por meio de Questionário de Frequência do Consumo de Alimentos. Resultados: A porcentagem de casos confirmados com DMV foi de 3,2%, sendo semelhante entre os sexos. Observou-se, de forma estatisticamente significante, maior frequência de indivíduos com DMV (confirmados ou suspeitos) entre aqueles de primeira geração, com idade ≥ 60 anos, tabagistas, com hipertensão arterial, hipertrigliceridemia e diabetes. Nipo-brasileiros com DMV (confirmados ou suspeitos) apresentaram menor perímetro do quadril e maior idade, pressão arterial sistólica, triglicérides, glicemia, consumo de alimentos fonte de ferro e menor fonte de fibras de grãos. Encontrou-se diferença estatisticamente significante apenas para o consumo de gordura saturada (análise bruta: segundo terço versus primeiro terço). Conclusões: programas de educação nutricional devem ser incentivados neste grupo com alta prevalência de doenças crônicas não transmissíveis. Arq Bras Endocrinol Metab. 2009;53(7):865-73.Descritores Doença macrovascular; consumo de alimentos; nipo-brasileiros; dieta AbstRAct Objective: To describe the food intake of Japanese-Brazilians with and without macrovascular disease (MVD). Methods: MVD was defined, for 1,165 Japanese-Brazilians, by scores attributed to the health historical, electrocardiogram and ankle-brachial index values. The usual dietary intake was determined using a food frequency questionnaire. Results: The MVD prevalence was of 3.2%, being similar among genders. Statistically higher frequencies of individuals with MVD were observed among those of first generation, with age ≥ 60 years, tobacco user, with hypertension, hypertriglyceridemia and diabetes. Subjects with MVD were older, with smaller hip circumference, and higher systolic blood pressure levels, triglycerides and glycemia concentration; they informed higher consumption of iron source food and smaller of grains fibers. Statistically significant difference was found to saturated fat (crude analysis: second tercile versus first tercile). Conclusions: Programs of nutritional education should be stimulated in this group with high prevalence of non-communicable chronic diseases. Arq Bras Endocrinol Metab.2009;53(7):865-73.

show abstract

“…19 One of the highest prevalence rates of diabetes worldwide have been reported in Japanese-Brazilians 5 who also have many other cardiovascular risk factors. 16 Cardiovascular disease was seen in 14% of this population 20 RESULTADOS: Durante a intervenção, foram observadas maiores reduções anuais médias (dp) na circunferência da cintura [-0,5(3,8) vs. 1,2(1,2) cm/ano, p < 0,001], pressão arterial sistólica [-4,6(17,9) [1,2(5,8) vs. -0,7(2,2) UI/mL/ano, p < 0,001], comparado com o período pré-intervenção. Ocorreram reduções signifi cativas na prevalência de glicemia de jejum alterada e tolerância à glicose diminuída após um ano de intervenção (de 58,4% para 35,4%, p < 0,001; e de 30,1% para 21,7%, p = 0,004, respectivamente).…”

unclassified

A behavioral intervention in a cohort of Japanese-Brazilians at high cardiometabolic risk

et al. 2012

View full text Add to dashboard Cite

.001] compared with the pre-intervention period. Signifi cant reductions in the prevalence of impaired fasting glucose/impaired glucose tolerance and diabetes were seen during the intervention (from 58.4% to 35.4%, p<0.001; and from 30.1% to 21.7%, p= 0.004, respectively). CONCLUSIONS:A one-year community-based health promotion program brings cardiometabolic benefi ts in a high-risk population of Japanese-Brazilians.

show abstract

Macrovascular disease in a Japanese–Brazilian population of high prevalence of metabolic syndrome: Associations with classical and non-classical risk factors

Cited by 14 publications

References 28 publications

Biomarkers of inflammation may be of use for identification of more severe peripheral arterial occlusive disease

Biomarkers of inflammation may be of use for identification of more severe peripheral arterial occlusive disease

Consumo alimentar e doença macrovascular em nipo-brasileiros: um estudo transversal

A behavioral intervention in a cohort of Japanese-Brazilians at high cardiometabolic risk

Contact Info

Product

Resources

About