Macular function assessed with mfERG before and after panretinal photocoagulation in patients with proliferative diabetic retinopathy

Lövestam-Adrian, Monica; Andréasson, Sten; Ponjavic, Vesna

doi:10.1007/s10633-004-4862-y

Cited by 17 publications

(12 citation statements)

References 31 publications

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“…No significant change in the macular thickness was observed. This agrees with a study in which no change in the macular thickness and reduced response densities after photocoagulation were found 17 . There was a negative correlation between the P1 response density in ring 1 and the corresponding macular thickness two days after the photocoagulation treatment.…”

Section: Discussionsupporting

confidence: 92%

“…Some patients with diabetic retinopathy who did not have macular oedema also reported a decline in colour contrast vision and contrast sensitivity after scatter treatment, indicating that their foveal function was still affected 17 . Previous research that examined the direct influence of laser burns, using focal laser treatment, showed increased amplitudes in areas with oedema and hard exudates; however, the results demonstrated decreased amplitudes in newly pan‐retinal photocoagulated areas and in untreated adjacent areas.…”

Section: Discussionmentioning

confidence: 96%

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Retinal function and morphology of severe non‐proliferative diabetic retinopathy before and after retinal photocoagulation

Zhang

Chan

et al. 2011

Clinical and Experimental Optometry

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Purpose:The purpose of this project was to investigate the changes in macular function and macular morphology of severe non-proliferative diabetic retinopathy (NPDR), due to photocoagulation, using the multifocal electroretinogram (mfERG) and optical coherence tomography (OCT). Methods: Thirty-five volunteers were in the control group, with one eye per person examined with the mfERG. Both the mfERG and OCT were conducted on 30 patients with diabetes who had severe NPDR before, and two, seven and 14 days after, treatment with photocoagulation. Results: Compared with the control group, the P1 and N1 response densities in the patients with NPDR appeared to decrease significantly at rings 2-3 and rings 3-4, respectively, whereas no difference was seen in the implicit times. At two days after photocoagulation, the P1 and N1 response densities decreased significantly in ring 1 and they were still lower than the pre-photocoagulation values at 14 days after photocoagulation. In addition, no change was found in the implicit times before and after photocoagulation. There was no obvious difference in the macular thickness after treatment. At two days after treatment, the P1 response density in ring 1 negatively correlated with the corresponding macular thickness. Conclusion:The para-macular function was significantly impaired in those patients with severe NPDR and photocoagulation reduced the central macular function. Even after 14 days, the central macular function had not returned to pre-photocoagulation levels.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Retinal function and morphology of severe non‐proliferative diabetic retinopathy before and after retinal photocoagulation

Zhang

Chan

et al. 2011

Clinical and Experimental Optometry

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“…170 It was found that although there were no significant changes in visual acuity and macular thickness on OCT, there were significant reductions in mfERG response amplitudes of the central rings at 6 months after PRP. The finding suggested retinal functional impairment may occur in the untreated macula following PRP.…”

Section: Focal Laser and Pan-retinal Photocoagulationmentioning

confidence: 91%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

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“…The development of mfERG, which was introduced by Sutter and Tran 1992 [13] has made it possible to study the macular region more accurately and allows us to evaluate the extent of macular dysfunction in an objective way [14][15][16][17]. A Correlation between macular oedema and mfERG response has been described previously [18,19,20].…”

Section: Introductionmentioning

confidence: 99%

In diabetic retinopathy, foveal thickness of 300 μm seems to correlate with functionally significant loss of vision

2007

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Macular function assessed with mfERG before and after panretinal photocoagulation in patients with proliferative diabetic retinopathy

Cited by 17 publications

References 31 publications

Retinal function and morphology of severe non‐proliferative diabetic retinopathy before and after retinal photocoagulation

Retinal function and morphology of severe non‐proliferative diabetic retinopathy before and after retinal photocoagulation

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

In diabetic retinopathy, foveal thickness of 300 μm seems to correlate with functionally significant loss of vision

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