Macular Function in Eyes With Early Age-Related Macular Degeneration With or Without Contralateral Late Age-Related Macular Degeneration

Parisi, Vincenzo; Perillo, Loredana; Tedeschi, Massimiliano; Scassa, C.; Gallinaro, Geltrude; Capaldo, N.; Varano, Monica

doi:10.1097/iae.0b013e318042d6aa

Cited by 67 publications

(63 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…VERIS Clinic™ 4.9 (Electro-Diagnostic Imaging, San Mateo, CA, USA) was used for mfERG assessment, using a previously published method [19,20]. In all patient and control eyes, mfERG was recorded in the presence of dilated pupils with 1% tropicamide.…”

Section: Functional Testingmentioning

confidence: 99%

Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine

Tanga

Centofanti

Oddone

et al. 2011

Graefes Arch Clin Exp Ophthalmol

Self Cite

View full text Add to dashboard Cite

Background Antimalarial drugs such as chloroquine (CQ) and hydroxychloroquine (HCQ) are mainly used in the treatment of rheumatologic diseases, and their use may be associated with irreversible retinal toxicity. Previous studies indicate early paracentral visual field loss (Humphrey 10-2) in patients taking HCQ". These paracentral defects appear before changes in other clinical parameters as visual acuity and fundoscopy. The mechanism of CQ toxicity remains unclear. It was reported that toxic doses of CQ administered for as long as 4.5 years to Rhesus monkeys caused an initial dramatic effect on ganglion cells, followed later by photoreceptors and RPE degeneration. The purpose of this study is to explore early retinal functional changes measured by frequency-doubling technology (FDT) in patients treated with hydroxychloroquine (HCQ). Methods Forty-eight eyes of 48 subjects treated with hydroxychloroquine (HCQ), with no signs of retinal toxicity, and 36 eyes of 36 age and sex-matched healthy subjects were enrolled in this cross-sectional, prospective, observational, case control study. Functional testing included frequency-doubling Humphrey-matrix perimetry (FDP), white-on-white Humphrey visual field perimetry (HFA), using the 24-2 and 10-2 threshold programs, multifocal electroretinogram (mfERG, Veris 4.9) and low contrast sensitivity (CS) measurement. Results FDP mean deviation (MD) was found to be significantly reduced in HCQ-treated patients compared to controls both in the 24-2 (−1.38±2.41 dB vs 0.21±1.83dB, p<0.01) and in the 10-2 program (−0.97 ±2.88 dB vs 0.15± 1.72dB, p<0.01). FDP pattern standard deviation (PSD) was found to be significantly worse in HCQ-treated patients compared to controls both in the 24-2 (2.70±0.65 dB vs 2.41±0.31 dB, p<0.01 and in the 10-2 program (2.86± 0.48 dB vs 2.48 ±0.39 dB, p<0.01). HFA PSD and CS was also significantly reduced in HCQ patients, while response amplitude densities (RAD) were similar between patients and controls. A statistically significant difference in the ratio of the 5°-10°RAD and the 0°-2.5°RAD (0.31±0.08 vs 0.36±0.07 respectively, p<0.05) was found between groups. Conclusion Frequency doubling perimetry could be useful to detect early retinal impairment in patients treated with hydroxychloroquine.

show abstract

Section: Functional Testingmentioning

confidence: 99%

Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine

Tanga

Centofanti

Oddone

et al. 2011

Graefes Arch Clin Exp Ophthalmol

Self Cite

View full text Add to dashboard Cite

show abstract

“…[24][25][26][27][28][29][30][31][32][33] Microperimetry has detected photoreceptor abnormalities even before GA develops, and this strategy can also predict the area where existing GA will likely progress. [34][35][36][37][38][39][40] These histopathologic, electrophysiologic, and microperimetric findings in eyes with GA, along with the early visual function deficits and symptoms observed in patients even before GA develops, 41 suggest that photoreceptor dysfunction precedes the appearance and progression of GA in some eyes. These findings would also suggest that an anatomic correlate should exist away from the margin of GA that could be visualized using SD-OCT imaging.…”

Section: Introductionmentioning

confidence: 99%

Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

Nunes¹,

Gregori²,

Yehoshua³

et al. 2013

Ophthalmic Surg Lasers Imaging Retina

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVE: Spectral-domain optical coherence tomography (SD-OCT) en face imaging was used to measure the growth of geographic atrophy (GA) and identify baseline anatomic changes in the outer retina in eyes with nonexudative age-related macular degeneration (AMD). PATIENTS AND METHODS: In this prospective study, eyes were imaged using 200 × 200 and 512 × 128 A-scan raster patterns. Outer retinal anatomy was visualized using en face imaging of a 20-μm thick slab encompassing the inner segment/outer segment (IS/OS) band. RESULTS: En face SD-OCT imaging of the IS/OS region revealed a bilaterally symmetrical pattern of outer retinal disruption extending beyond the borders of GA that accurately predicted the progression of GA over 1 year in 13 of 30 eyes (43.3%). In the remaining cases, the area of disruption was much larger than the area of progression. CONCLUSION: En face imaging of the outer retina can predict the growth of GA in some eyes. Due to the bilateral symmetry of these findings, this imaging strategy may identify a genetic subset of patients in whom photoreceptor loss precedes the progression of GA. These areas with outer retinal disruption should be followed in clinical trials designed to test treatments for dry AMD. [ Ophthalmic Surg Lasers Imaging Retina. 2013;44:344–359.]

show abstract

“…19 Moreover, while FERG allows the electrophysiological evaluation of preganglionic elements in response to luminance stimuli presented in a restricted part of the central retina (4-9 retinal degrees), 1,2,20 the mfERG technique is useful for assessing responses of several different retinal areas enclosed between 18 and 208 of eccentricity from the fovea. [21][22][23] In fact, while the FERG recording collects the contribution from the entire macular region, mfERG ring analysis allows separating selective measures of bioelectrical responses obtained from localized macular areas. 22,23 This means that recording mfERG, testing visual acuity, and performing automated visual field analysis make it possible to explore the entire central retina and, through appropriate data analysis, to receive selective information regarding the function of localized retinal regions.…”

mentioning

confidence: 99%

Macular Function in Eyes with Open-Angle Glaucoma Evaluated by Multifocal Electroretinogram

Parisi

Ziccardi

Centofanti³

et al. 2012

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

PURPOSE. To evaluate macular function in patients with openangle glaucoma (OAG) by means of multifocal electroretinogram (mfERG).METHODS. Twenty-four OAG patients (mean age 54.6 6 9.1 years) and 14 age-similar controls were enrolled. OAG patients had intraocular pressure (IOP) less than 18 mm Hg with topical medical treatment, 24-2 visual field (Humphrey Field Analyzer [HFA]) with mean deviation (MD) between À2 and À12 dB, and corrected pattern standard deviation (CPSD) between þ2 and þ10 dB and no history or presence of cataract and/or macular disease. MfERGs in response to 61 M-stimuli presented to the central 208 of the visual field were assessed in OAG patients (24 eyes) and in controls (14 eyes). Ring (R) analysis was performed every five retinal eccentricities in areas between the fovea and midperiphery: 08 to 2.58 (R1), 2.58 to 58 (R2), 58 to 108 (R3), 108 to 158 (R4), and 158 to 208 (R5). MfERG response amplitude density of the N1-P1 components (N1-P1 RAD, nV/deg 2 ) and P1 implicit time (P1 IT, ms) of the firstorder binary kernel were measured for each ring.RESULTS. OAG patients showed a significant (P < 0.01) decrease in N1-P1 RADs and an increase in P1 IT in both R1 and R2 with respect to controls. The reduction in N1-P1 RADs was significantly (P < 0.01) correlated with HFA MD and CPSD. No other significant differences between OAG and controls were found.CONCLUSIONS. OAG patients show macular dysfunction detectable by the mfERG technique. Since the mfERG N1-P1 component is thought to be generated by preganglionic elements (photoreceptors and OFF bipolar cells), our data support the functional impairment of the neural generators of the macular region in patients with glaucoma. (Invest Ophthalmol Vis Sci. 2012;53:6973-6980)

show abstract

Macular Function in Eyes With Early Age-Related Macular Degeneration With or Without Contralateral Late Age-Related Macular Degeneration

Abstract: In eyes with early AMD there is a dysfunction of preganglionic elements in the central 0-5 retinal degrees detectable by mfERG or MP-1 microperimetry. This impairment is not further influenced by the presence of late AMD in the fellow eye.

Cited by 67 publications

References 44 publications

Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine

Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine

Predicting the Progression of Geographic Atrophy in Age-Related Macular Degeneration With SD-OCT En Face Imaging of the Outer Retina

Macular Function in Eyes with Open-Angle Glaucoma Evaluated by Multifocal Electroretinogram

Contact Info

Product

Resources

About