Macular function measured by binocular mfERG and compared with macular structure in healthy children

Molnar, Anna E. C.; Andréasson, Sten; Larsson, Eva; Åkerblom, Hanna; Holmström, Gerd

doi:10.1007/s10633-015-9513-y

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…Although some differences stand out, the mean values and ranges of the mfERG parameters evaluated in the present study at baseline conditions of the two groups (Table 1, Figs. 3 and 4) were similar to those reported in previous studies [18][19][20]. The differences may be related to different recording systems, as well as age, sample size, and different stimulation paradigms including different m-sequences.…”

Section: Discussionsupporting

confidence: 86%

“…This might explain the differences observed between the two study groups in P1 and N2 amplitudes as well as N1, P1 and N2 times. In fact, some studies showed a decrease in the amplitude and an increase in peak times with age [16][17][18]. Although some differences stand out, the mean values and ranges of the mfERG parameters evaluated in the present study at baseline conditions of the two groups (Table 1, Figs.…”

Section: Discussioncontrasting

confidence: 47%

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Impact of contact lens materials on the mfERG response of the human retina

et al. 2019

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Purpose To investigate the effect of different hydrophilic and rigid gas-permeable contact lens (CL) materials on multifocal electroretinography (mfERG). Methods The mfERG was recorded in 18 healthy subjects with RETI-port/scan21 TM : 11 subjects underwent mfERG recording wearing two different hydrophilic CLs with different water contents in a randomized order (1 silicone hydrogel-Comfilcon A, 48%EWC, and 1 hydrogel-Omafilcon A, 62% EWC) and 7 other subjects wore a hydrophobic rigid gas-permeable scleral lens (SL)-Hexafocon A. Control measures were recorded without CL in both groups. mfERG recordings were performed with a stimulus array pattern of 103-scaled hexagons displayed on a 19-inch RGB monitor at 28 cm distance at a frame rate of 60 Hz. The amplitude (nV), implicit time and response density (nV/deg 2) of the first-order

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 47%

Impact of contact lens materials on the mfERG response of the human retina

et al. 2019

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“…Gerth et al 18 found that amplitude and implicit time of the mfERG do not change significantly over these ages in normal subjects. Molnar et al 19 found no significant relationship between age and amplitude in 5- to 15-year-old term-born children; implicit time increased slightly.…”

Section: Methodsmentioning

confidence: 93%

Multifocal ERG Responses in Subjects With a History of Preterm Birth

Altschwager

Moskowitz

Fulton

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeThe purpose of this study is to assess cone-mediated central retinal function in children with a history of preterm birth, including subjects with and without retinopathy of prematurity (ROP). The multifocal electroretinogram (mfERG) records activity of the postreceptor retinal circuitry.MethodsmfERG responses were recorded to an array of 103 hexagonal elements that subtended 43° around a central fixation target. The amplitude and latency of the first negative (N1) and first positive (P1) response were evaluated in six concentric rings centered on the fovea. Responses were recorded from 40 subjects with a history of preterm birth (severe ROP, mild ROP, no ROP) and 19 term-born control subjects.ResultsThe amplitude of N1 and P1 varied significantly with eccentricity and ROP severity. For all four groups, these amplitudes were largest in the center and decreased with eccentricity. At all eccentricities, N1 amplitude was significantly smaller in severe ROP and did not differ significantly among the other three groups (mild ROP, no ROP, term-born controls). P1 amplitude in all preterm groups was significantly smaller than in controls; P1 amplitude was similar in no ROP and mild ROP and significantly smaller in severe ROP.ConclusionsThese results provide evidence that premature birth alone affects cone-mediated central retinal function and that the magnitude of the effect varies with severity of the antecedent ROP. The lack of difference in mfERG amplitude between the mild and no ROP groups is evidence that the effect of ROP on the neurosensory retina may not depend solely on appearance of abnormal retinal vasculature.

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“…The mfERG has better spatial resolution than the PERG and full-field ERGs, and enables further characterisation of the size and location of macular abnormality, but requires steady fixation, reliable co-operation, as well as the use of contact electrodes [ 16 ] making it difficult for paediatric patients. One study has shown that the mfERG can be reliably recorded in healthy full-term children from 5 years of age and above with the use of topical anaesthesia to aid tolerance to corneal electrodes [ 68 ]. The mfERG was used to establish an early diagnosis of macular dysfunction in two paediatric cases with Stargardt disease using topical anaesthesia [ 69 ].…”

Section: Central Visual-field Defectmentioning

confidence: 99%

What can visual electrophysiology tell about possible visual-field defects in paediatric patients

Handley

Šuštar

Pompe

2021

Eye

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Recognising a potential visual-field (VF) defect in paediatric patients might be challenging, especially in children before the age of 5 years and those with developmental delay or intellectual disability. Visual electrophysiological testing is an objective and non-invasive technique for evaluation of visual function in paediatric patients, which can characterise the location of dysfunction and differentiate between disorders of the retina, optic nerve and visual pathway. The recording of electroretinography (ERG) and visual-evoked potentials (VEP) is possible from early days of life and requires no subjective input from the patient. As the origins of ERG and VEP tests are known, the pattern of electrophysiological changes can provide information about the VF of a child unable to perform accurate perimetry. This review summarises previously published electrophysiological findings in several common types of VF defects that can be found in paediatric patients (generalised VF defect, peripheral VF loss, central scotoma, bi-temporal hemianopia, altitudinal VF defect, quadrantanopia and homonymous hemianopia). It also shares experience on using electrophysiological testing as additional functional evidence to other tests in the clinical challenge of diagnosing or excluding VF defects in complex paediatric patients. Each type of VF defect is illustrated with one or two clinical cases.

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Macular function measured by binocular mfERG and compared with macular structure in healthy children

Cited by 4 publications

References 33 publications

Impact of contact lens materials on the mfERG response of the human retina

Impact of contact lens materials on the mfERG response of the human retina

Multifocal ERG Responses in Subjects With a History of Preterm Birth

What can visual electrophysiology tell about possible visual-field defects in paediatric patients

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