Macular ganglion cell complex parameters by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes

Lotfy, Nancy M; Alasbali, Tariq; Khandekar, Rajiv

doi:10.4103/ijo.ijo_1378_18

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…The observed dissociation between changes in pRNFL thickness and other OCT parameters in MS patients may at least partially explain the results of our study. Support for this concept also comes from a study performed by Lotfy et al [64], who found lower macular RNFL thickness in MS patients without ON compared with healthy controls, and no differences in pRNFL thickness between the two groups. Based on published results that show a better correlation of visual function and disability in MS patients and macular ganglion cell layer thickness than pRNFL [68], we can assume that in our MS patients, axonal degeneration may be more pronounced than in NSWMLs patients, and that the measurement of GCIPL and mRNFL thickness is more reliable than pRNFL in the differential diagnosis of MS.…”

Section: Discussionmentioning

confidence: 79%

“…Surprisingly, we did not observe any differences in segmental and average thickness of the pRNFL between MS and NSWMLs patients. Thinning of the pRNFL has been observed in MS-ON and also in MS-NON eyes [39,60,63,64]. However, some results did not confirm these observations [39,[64][65][66][67].…”

Section: Discussionmentioning

confidence: 91%

“…Thinning of the pRNFL has been observed in MS-ON and also in MS-NON eyes [39,60,63,64]. However, some results did not confirm these observations [39,[64][65][66][67]. Data comparing pRNFL thickness in MS and NSWMLs patients are scarce.…”

Section: Discussionmentioning

confidence: 94%

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Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions

Siger

Owidzka

Świderek-Matysiak

et al. 2021

Sensors

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In the differential diagnosis of nonspecific white matter lesions (NSWMLs) detected on magnetic resonance imaging (MRI), multiple sclerosis (MS) should be taken into consideration. Optical coherence tomography (OCT) is a promising tool applied in the differential diagnostic process of MS. We tested whether OCT may be useful in distinguishing between MS and NSWMLs patients. In patients with MS (n = 41) and NSWMLs (n = 19), the following OCT parameters were measured: thickness of the peripapillary Retinal Nerve Fibre Layer (pRNFL) in superior, inferior, nasal, and temporal segments; thickness of the ganglion cell-inner plexiform layer (GCIPL); thickness of macular RNFL (mRNFL); and macular volume (MV). In MS patients, GCIPL was significantly lower than in NSWMLs patients (p = 0.024). Additionally, in MS patients, mRNFL was significantly lower than in NSWMLs patients (p = 0.030). The average segmental pRNFL and MV did not differ between MS and NSWMLs patients (p > 0.05). GCIPL and macular RNFL thinning significantly influenced the risk of MS (18.6% [95% CI 2.7%, 25.3%]; 27.4% [95% CI 4.5%, 62.3%]), and reduced GCIPL thickness appeared to be the best predictor of MS. We conclude that OCT may be helpful in the differential diagnosis of MS and NSWMLs patients in real-world settings.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 91%

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Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions

Siger

Owidzka

Świderek-Matysiak

et al. 2021

Sensors

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“…It has been demonstrated in the literature that RNFL in patients with early-diagnosed MS NON was no different than that of control subjects in 4 quadrants; however, there was signi cant thinning in MS NON patients in GCC. Based on these ndings, it can be speculated that patients with early-diagnosed MS present GCC symptoms earlier than RNFL symptoms [15]. Similarly, a meta-analysis reported that the ganglion cell layer was signi cantly thinner in the MS ON and MS NON groups compared to the control group and that the inner plexiform layer was signi cantly thinner in the ganglion cell inner plexiform layer MS ON group compared to the MS NON group [17].…”

Section: Discussionmentioning

confidence: 95%

Evaluation of optical coherence tomography findings in patients with multiple sclerosis and glaucoma

Uctepe,

Orenc,

Gungel

et al. 2024

Int Ophthalmol

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Glaucoma and multiple sclerosis (MS) can cause optic disc pathology and, in this way, affect optical coherence tomography (OCT) data. In this context, the objective of this study is to investigate the changes in the mean, quadrant, and sector data measured by OCT in glaucoma and MS patients. MethodsThe sample of this prospective cohort study consisted of 42 MS patients (84 eyes), 34 Primary openangle glaucomas (POAG) patients (67 eyes), and 24 healthy control subjects (48 eyes). The MS group was divided into two groups according to the presence of a history of optic neuritis. Accordingly, those with a history of optic neuritis were included in the MS ON group, and those without a history of optic neuritis were included in the MS NON group. The differences between these groups in the mean, quadrant, and sector data related to the retinal nerve ber layer (RNFL) and ganglion cell complex (GCC) were evaluated. ResultsSuperior nasal (SN), superior temporal (ST), inferior nasal (IN), and superior quadrant (SUP) values were signi cantly lower in the glaucoma group than in the MS group (p < 0.05). The mean superior GCC (GCC SUP) value was signi cantly lower in the MS ON group than in the glaucoma group (p < 0.05). On the other hand, SN, ST, inferior temporal (IT), IN, average RNFL (AVE RNFL), semi-average superior RNFL (SUP AVE RNFL), semi-average inferior RNFL (INF AVE RNFL), SUP, and inferior quadrant RNFL (INF) values were signi cantly lower in the glaucoma group than in the MS NON group (p < 0.05). ConclusionRNFL and GCC parameters get thinner in MS and glaucoma patients. While the inferior and superior RNFL quadrants are more frequently affected in glaucoma patients, the affected quadrants vary according to the presence of a history of optic neuritis in MS patients. It is noteworthy that the GCC superior quadrant was thin in MS ON patients. The ndings of this study indicate that OCT data may be valuable in the differential diagnosis of glaucoma and MS.

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“…examined regions (macula, ganglion cell complex, and RNF). In glaucoma patients the ganglion cell complex in the inferior temporal outer sector was reported to be the most useful variable (area under the ROC curve 0.86; [6]). Loss of ganglion cells may be simpler to detect than that in the peripheral retina due to the multilayer structure of these cells' bodies.…”

Section: Introductionmentioning

confidence: 99%

Correlations between peripapillary retinal nerve fiber layer thickness and macular thickness in different stages of primary open-angle glaucoma, an OCT study

Salah,

El Habbak,

Salem

et al. 2023

Benha Journal of Applied Sciences

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Background: Progressive optic nerve degeneration and loss of visual field are hallmarks of primary open-angle glaucoma, the most common cause of permanent blindness globally. The evaluation of structures in glaucoma has become an essential technique. The evolution of technique gives better understand by examining the nerve fibre layer associations at stages of the illness. The purpose of this is to examine the correlations in all phases. Methods: Fifty eyeballs from fifty patients were collected from Ophthalmology Outpatient clinics for this comparative cross-sectional investigation. Group A included 25 eyes of patients with primary open-angle glaucoma; group B included 25 eyes of healthy volunteers as a comparison. Pupil response, visual acuity testing, anterior segment evaluation, gonioscopy, intraocular pressure measurement, and fundus examination were all part of the comprehensive ophthalmologic evaluations. and measures were collected, and high-quality pictures of the peripapillary region and macula were taken utilising Spectral-Domain imaging. Results: The There were statistically significant variations in BCVA, MD between the control and patient groups. Some parts of the macula were shown to have very high correlations with peripapillary. Predictive accuracy varied among phases, as seen by the ROC analysis. Conclusions: Differences in the control and patien groups are highlighted by this research. With varied predictive accuracy throughout disease stages, emerges as a viable diagnostic tool.

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Macular ganglion cell complex parameters by optical coherence tomography in cases of multiple sclerosis without optic neuritis compared to healthy eyes

Cited by 9 publications

References 26 publications

Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions

Optical Coherence Tomography in the Differential Diagnosis of Patients with Multiple Sclerosis and Patients with MRI Nonspecific White Matter Lesions

Evaluation of optical coherence tomography findings in patients with multiple sclerosis and glaucoma

Correlations between peripapillary retinal nerve fiber layer thickness and macular thickness in different stages of primary open-angle glaucoma, an OCT study

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