Background: Progressive optic nerve degeneration and loss of visual field are hallmarks of primary open-angle glaucoma, the most common cause of permanent blindness globally. The evaluation of structures in glaucoma has become an essential technique. The evolution of technique gives better understand by examining the nerve fibre layer associations at stages of the illness. The purpose of this is to examine the correlations in all phases. Methods: Fifty eyeballs from fifty patients were collected from Ophthalmology Outpatient clinics for this comparative cross-sectional investigation. Group A included 25 eyes of patients with primary open-angle glaucoma; group B included 25 eyes of healthy volunteers as a comparison. Pupil response, visual acuity testing, anterior segment evaluation, gonioscopy, intraocular pressure measurement, and fundus examination were all part of the comprehensive ophthalmologic evaluations. and measures were collected, and high-quality pictures of the peripapillary region and macula were taken utilising Spectral-Domain imaging. Results: The There were statistically significant variations in BCVA, MD between the control and patient groups. Some parts of the macula were shown to have very high correlations with peripapillary. Predictive accuracy varied among phases, as seen by the ROC analysis. Conclusions: Differences in the control and patien groups are highlighted by this research. With varied predictive accuracy throughout disease stages, emerges as a viable diagnostic tool.