Macular Pigment and Visual Performance in Glare: Benefits for Photostress Recovery, Disability Glare, and Visual Discomfort

Stringham, James M.; Garcia, Paul V.; Smith, Peter A.; McLin, Leon N.; Foutch, Brian K.

doi:10.1167/iovs.10-6699

Cited by 108 publications

(139 citation statements)

References 38 publications

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“…15 It is possible that the altered MP distribution contributes to functional loss, as it has been shown that MP increases macular function and reduces glare. [25][26][27] Moreover, focal displacement of MP and the resulting reduced protection from blue-light exposure might result in increased photo-oxidative stress in the outer retina. This could potentially lead to increased light-associated retinal damage, as suggested for another disease, macular telangiectasia type 2, with its characteristic central loss of MP.…”

Section: Discussionmentioning

confidence: 99%

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

Waldstein

Hickey

Mahmud

et al. 2012

Eye

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Purpose To evaluate the application of 488 and 514 nm fundus autofluorescence (FAF) and macular pigment optical density (MPOD) imaging in diabetic macular oedema (DMO) and to demonstrate the typical imaging features. Patients and Methods A hundred and twentyfive eyes of 71 consecutive patients with diabetic retinopathy who underwent examination at a specialist university clinic employing a modified Heidelberg Retina Angiograph, using two different light sources of 488 and 514 nm wavelength, were retrospectively reviewed. MPOD images were calculated using modified Heidelberg Eye Explorer software. All images were evaluated by two independent masked graders. Features from FAF and MPOD images were correlated with optical coherence tomography (OCT) imaging findings and inter-grader variability, sensitivity and specificity were calculated using OCT as reference. Results Sixty-seven eyes had DMO on OCT. The inter-grader variability was 0.84 for 488 nm FAF, 0.63 for 514 nm FAF and 0.79 for MPOD imaging. Sensitivity and specificity for detection of DMO were 80.6 and 89.7% for 488 nm FAF; 55.2 and 94.8% for 514 nm FAF; and 80.6 and 91.4% for MPOD imaging. In 488 nm FAF and MPOD imaging, DMO was better visualised in comparison with 514 nm FAF imaging, Po0.01. MPOD revealed displacement of macular pigment by intraretinal cysts. Conclusion MPOD imaging, and particularly its combination with 488 nm and 514 nm FAF, provides a valuable addition to OCT in the evaluation of DMO and is clinically useful in rapid en-face assessment of the central macula.

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Section: Discussionmentioning

confidence: 99%

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

Waldstein

Hickey

Mahmud

et al. 2012

Eye

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“…Similar to data generated for glare discomfort, it has also been shown that subjects with higher macular pigment levels maintained acuity beter than subjects with lower levels when exposed to both bright white light and short wavelength (blue) light. Additionally, lutein and zeaxanthin supplementation improved glare disability under these conditions [20].…”

Section: Glare Discomfort and Disability Glarementioning

confidence: 98%

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Rai¹,

Rai²

2017

Functional Food - Improve Health Through Adequate Food

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The identiication of bioactive food components and understanding their role as adjunct therapeutic agents in disease management and prevention has become a signiicant area of research. Accumulating evidence suggests a link between certain bioactive food components and health outcomes, for example, lutein and zeaxanthin for visual performance and delaying age-related macular degeneration, probiotics for gastrointestinal outcomes related to irritable bowel syndrome or prebiotics for its potential programming of the microbiome in early life to inluence later life outcomes.. This rapidly developing science has triggered discussions to determine if public health recommendations can be made on bioactive foods. However, regulatory guidance is necessary to guide the development the science, it's consideration for public health policy and the communication thereof to both healthcare professionals and consumers. This chapter will focus on the clinical and basic science supporting a role for lutein and pre-and probiotics in modulating several aspects of human health, including the gut microbiome through the human lifecycle. Opportunities to translate the science to consumers in a meaningful and accurate way will also be highlighted along with the regulatory landscape to shape the testing, communication and commercialization of these bioactives.

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“…High MPOD levels may lead to a reduction in photostress recovery time and glare discomfort, but does not increase target visibility or decrease glare disability if the target and surround luminance share the same wavelength conditions. It has been identified that MPOD has a positive effect on disability glare which suggests that MPOD may also have a role in the reduction of intraocular straylight 40,41 . Puell et al found that inter-subject differences in foveal MPOD showed a significant correlation with intraocular scatter in healthy, non-cataractous eyes 42 .…”

Section: Photostress (Scotomatic) Glare:-mentioning

confidence: 99%

Overview of Glare Types and Their Relationship With Macular Pigment Optical Density.

Putnam¹

2017

IJAR

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Macular Pigment and Visual Performance in Glare: Benefits for Photostress Recovery, Disability Glare, and Visual Discomfort

Cited by 108 publications

References 38 publications

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

Leveraging Bioactives to Support Human Health through the Lifecycle: Scientific Evidence and Regulatory Considerations

Overview of Glare Types and Their Relationship With Macular Pigment Optical Density.

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