Macular Pigment in Eyes With Macular Hole Formation and Its Change After Surgery

Obana, Akira; Nakazawa, Risa; Noma, Saki; Sasano, Hironobu; Gohto, Yuko

doi:10.1167/tvst.9.11.28

Cited by 6 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High concentrations of MP are normally present in the macula area, and various aspects of MP disruption in retinal diseases have been described. In clinical practice, MP can be enhanced and evaluated using the two-wavelength fundus autofluorescence technique [ 5 , 6 ]. Here, we provide the first report of the digital enhancement of MP visualization during surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Filter 1 was useful for assessing MP integrity at the end of surgery, and it highlighted the presence of a full-thickness macular hole in one case. Several abnormalities of MP distribution have been described at various stages of macular hole development [ 6 ]. However, this filter should be evaluated in a large series of vitreomacular traction operations using simultaneous correlation with intraoperative OCT.…”

Section: Discussionmentioning

confidence: 99%

“…Aspects of MP disruption have been described in surgical retinal diseases, mostly in vitreomacular traction and epiretinal proliferation associated with lamellar or macular hole diseases. Indeed, Obana et al recently described the appearance of MP in eyes with different stages of macular holes [ 6 ]. They observed a lack of MP within the hole in an area corresponding to an outer plexiform layer defect.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Sandali

Hassani

Balamoun³

et al. 2023

JCM

View full text Add to dashboard Cite

Purpose: To describe the feasibility of intraoperative digital visualization and its contribution to the enhancement of macular pigmentation visualization in a prospective series of macular surgery interventions. Materials and Methods: A prospective, single-center, single-surgeon study was performed on a series of 21 consecutive cases of vitrectomy for various types of macular surgery using a 3D visualization system. Two optimized filters were applied to enhance the visualization of the macular pigment (MP). For filter 1, cyan, yellow, and magenta color saturations were increased. Filter 2 differed from filter 1 only in having a lower level of magenta saturation for the green-magenta color channel. Results: Optimized digital filters enhanced the visualization of the MP and the pigmented epiretinal tissue associated with the lamellar and macular holes. In vitreomacular traction surgery, the filters facilitated the assessment of MP integrity at the end of surgery. Filter 1 enhanced MP visualization most strongly, with the MP appearing green and slightly fluorescent. Filter 2 enhanced MP visualization less effectively but gave a clearer image of the retinal surface, facilitating safe macular peeling. Conclusion: Optimized digital filters could be used to enhance MP and pigmented epiretinal tissue visualization during macular surgery. These filters open new horizons for future research and should be evaluated in larger series and correlated with intraoperative OCT.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Sandali

Hassani

Balamoun³

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…The relationship between the central- dip and AMD is still unclear because the mechanism of the formation of the central-dip is unclear. Mueller cells at the fovea contain macular pigment, and in many cases, the central dip is produced by the damage to Mueller cell cones induced by vitreous traction [ 66 – 68 ]. Furthermore, it is unknown whether the damage in Mueller cells, and not diminished pigment, becomes the risk factor for AMD development.…”

Section: Discussionmentioning

confidence: 99%

Foveal macular pigment dip in offspring of age-related macular degeneration patients is inversely associated with omega-3 index

et al. 2020

View full text Add to dashboard Cite

Background Offspring of parent(s) with age-related macular degeneration (AMD) have a 45% lifetime risk of developing the disease. High foveal macular pigment optical density (MPOD) is protective, whereas individuals with a “foveal macular pigment dip” (FMPD) are at increased risk. Shortage of the dietary carotenoids lutein, zeaxanthin as well as fish consumption are reported AMD risk factors. This Early Biomarkers of AMD (EBAMD) study evaluates serum factors that protect foveal MPOD architecture in Caucasian offspring of parent(s) with AMD. Methods N = 130 subjects [mean (SD) age 62.8 (8.6) years; 36/94 male/female] were recruited from Scripps Health/ Scripps Memorial Hospital/ Scripps Mericos Eye Institute between 2012 and 2017. Macula pigment 3D topography was evaluated using specular reflectance. Buccal genetic cheek swab, circulating serum dietary carotenoids and long-term RBC omega-3 fatty acid status, as well as common secondary clinical structural and vision function parameters were obtained. Results 41 % of offspring of AMD parent(s) presented with FMPD. These offspring were about 4 years younger than those without FMPD (controls; P = 0.012) and had thinner foveas (P = 0.010). There were no differences in gender, BMI, % body fat, visual acuity or contrast sensitivity between those with and without FMPD. % RBC membrane docosahexaenoic acid (DHA) was reduced in FMPD offspring vs. control offspring (P = 0.04). The Omega-3 Index was significantly decreased in the FMPD group (P = 0.03). Conclusions The percentage of FMPD in AMD offspring is nearly twice that reported for the general population in the scientific literature. Offspring presenting FMPD had similar AMD genetic risk, but significantly reduced % RBC membrane omega-3 fatty acids and thinner foveas compared with those without FMPD. Our data supports the importance of ‘essential fatty’ acids as an independent AMD risk factor.

show abstract

“…The area within 0.5° lacks the inner layers of the retina, i.e., those from the inner nuclear layer to the nerve fiber one, and we consider that MP within this area exists in the Müller cell cone according to the hypothesis of Gass [ 19 ]. Investigations on retinal diseases, including macular telangiectasia type 2 [ 20 , 21 , 22 ], lamellar macular hole [ 23 ], and macular hole [ 24 , 25 ], support this assumption. A recent study using Raman microscopy revealed a more detailed distribution of MP in human histological specimens [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Lutein and Zeaxanthin Distribution in the Healthy Macula and Its Association with Various Demographic Factors Examined in Pseudophakic Eyes

et al. 2021

Self Cite

View full text Add to dashboard Cite

The macular pigment consisting of lutein (L) and zeaxanthin (Z) protects photoreceptors via its antioxidative and barrier activities. This study aimed to determine L and Z distribution in the healthy macula and their association with various demographic factors. Macular pigment optical density (MPOD) was measured using fundus autofluorescence spectroscopy in 352 pseudophakic eyes with no fundus diseases. Pseudophakia was chosen to avoid the influence of cataract in the measurement of fundus autofluorescence. The mean patient age was 72.3 ± 8.6 years. MPOD was analyzed separately in three zones, i.e., A: a central area within a radius of 0.5°, mainly containing Z; B: a ring area with radii from 0.5° to 1.3°, containing Z and L; C: a ring area with radii from 1.3° to 9°, containing L. Multivariate analyses were performed with MPOD as the dependent variable and sex, supplement intake, smoking habits, glaucoma, diabetes, age, body mass index (BMI), skin carotenoid levels, retinal thickness, retinal volume, axial length as the independent variables. The mean total MPOD volume within 9° eccentricity was 20,121 ± 6293. Age was positively associated with MPOD in all zones. Supplement and BMI were positively and negatively associated with MPOD in zones B and C. Smoking was negatively associated with MPOD in zone A. This study revealed the standard MP values of aged Japanese, which resulted to be higher than the previously reported values in other races. Age was found to have a positive association with MP values. L in the outer foveola was affected by BMI and supplements, but Z in the foveola was not. The amount of Z in the Müller cell cone may not be changed easily by factors such as hunger and satiety in the context of preservation of homeostasis in the human body, but tobacco had a negative effect on Z.

show abstract

Macular Pigment in Eyes With Macular Hole Formation and Its Change After Surgery

Cited by 6 publications

References 33 publications

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Operative Digital Enhancement of Macular Pigment during Macular Surgery

Foveal macular pigment dip in offspring of age-related macular degeneration patients is inversely associated with omega-3 index

Lutein and Zeaxanthin Distribution in the Healthy Macula and Its Association with Various Demographic Factors Examined in Pseudophakic Eyes

Contact Info

Product

Resources

About