2007
DOI: 10.1016/j.visres.2007.09.002
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Macular pigment, photopigments, and melanin: Distributions in young subjects determined by four-wavelength reflectometry

Abstract: We have developed an objective procedure, using a modified retinal camera, to determine macular pigment (MP) optical density distributions in the human retina. Using two multi-band filters, reflectance maps of the retinas of young subjects (<25 years old) were obtained at 460, 528, 610 and 670 nm, without pupil dilation. The log-transformed maps were combined linearly to yield optical density maps of MP, cone and rod photopigments, and melanin. MP optical density and heterochromatic flicker photometry results … Show more

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Cited by 41 publications
(34 citation statements)
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“…As such, it is often used as a standard against which other techniques are validated [e.g., [56][57][58][59][60], although at present there is no true 'goldstandard' in vivo measure of MPOD.…”
Section: Heterochromatic Flicker Photometrymentioning
confidence: 99%
“…As such, it is often used as a standard against which other techniques are validated [e.g., [56][57][58][59][60], although at present there is no true 'goldstandard' in vivo measure of MPOD.…”
Section: Heterochromatic Flicker Photometrymentioning
confidence: 99%
“…30 Prior multispectral retinal image analysis has been restricted, either in spatial extent to single line scans 31 or to pointwise acquisition, 32 or spectrally to a limited number of spectral bands. [33][34][35] While excellent focal analysis of MP has been possible with two wavelength reflectance 36,37 or AF, 36 we wanted to investigate the full 20 deg field with 76 bands of spectral information and explore the use of blind source separation to obtain detailed spectral characterization of MP in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…This is particularly important because (unlike in 1997) we now know from the literature that the distribution of macular pigment is not as simple as originally proposed (i.e., it cannot just be described as a firstorder exponential decline with increasing retinal eccentricity) (Delori FC, et al IOVS 2004;45:ARVO E-Abstract 1288). [6][7][8][9] Also, careful review of the papers cited by Professors Bone and Landrum, show that we are still lacking HPLC carotenoid distribution analysis information for central macular pigment. For example, there is no information in their papers about the distribution of the carotenoids at 0.258 or 0.58 eccentricity, and very little information at 1.08 of eccentricity (i.e., the 0.25-mm radius ¼ circa 18 eccentricity).…”
mentioning
confidence: 99%