Macular thickness measured by spectral-domain optical coherence tomography in healthy Thai eyes

Abstract

The normal macular thickness in Thais is thinner than those reported for other populations when measured using the Spectralis SD-OCT. Male gender and axial length were correlated positively with CSF thickness.

Influence of Clinical Factors and Magnification Correction on Normal Thickness Profiles of Macular Retinal Layers Using Optical Coherence Tomography

“…Gender also had a significant contribution to macular retinal thickness. The results of thinner macula in females than in males agree with previous reports [ 9 – 14 , 16 , 17 , 19 , 20 , 22 – 26 ]. In this study subjects, males were significantly younger than females although even distribution of subjects by gender was aimed.…”

“…Without magnification correction, a negative correlation between axial length and retinal thickness in the macula has been reported for full thickness [ 13 , 14 , 16 , 17 , 20 , 22 , 26 , 28 ] and also for GCC [ 22 , 29 ] and GCLIPL [ 9 , 12 , 29 , 30 ], while RNFL thickness of the macular area had a positive correlation with axial length [ 29 ]. Our results, which corroborate the earlier reports, may be explained by the normal thickness profile of each retinal layer determined by spectral-domain OCT [ 10 , 39 ].…”

“…Determinants of macular layer thickness in normal subjects have been extensively studied in order to establish a normative database for improving diagnostic accuracy [ 7 – 10 ] and also to reveal normal anatomical nature of the macula by utilizing data from population-based studies [ 11 – 14 ]. Various factors including age [ 7 , 9 – 22 ], gender[ 7 – 14 , 16 – 20 , 22 – 26 ], ethnicity [ 7 – 9 , 25 , 26 ], eye laterality [ 8 , 9 ], axial length [ 9 – 14 , 16 – 18 , 20 , 22 , 23 , 26 – 30 ], refractive error [ 11 , 12 , 14 , 17 , 18 , 20 , 22 , 23 , 26 – 28 , 30 ], corneal curvature [ 13 , 14 , 18 ], and signal strength [ 9 , 12 , 18 , 31 ] have been selected as potential candidates that may influence retinal layer thickness in the macula. However, only a few studies have conducted a multivariate regression analysis to determine the relationship between various clinical factors and the thickness of multiple retinal layers [ 10 , 17 , 18 , ...…”

“…A number of studies reported the significant effects of axial length on the retinal layer thickness in the macula [ 9 , 11 , 12 – 14 , 16 , 17 , 20 , 22 , 26 – 29 , 32 ]. Some authors speculated that retinal thinning in myopic eyes may result from mechanical stretching of the sclera along with axial elongation [ 13 , 14 , 17 , 23 , 27 ].…”

Normative Study to Correlate the Effects of Morphological Variables on Macular and Choroidal Thickness Using SD-OCT

“…[2] Studies have reported significant differences in macular thickness amongst subjects of different race, gender and age. [3,4] Thus it is desirable that measurements derived from the normative population be as close as possible to the population for which the instrument is to be used.…”