Macular vessel density differs in multiple sclerosis and neuromyelitis optica spectrum disorder: An optical coherence tomography angiography study

Rogaczewska, Małgorzata; Michalak, Sławomir; Stopa, Marcin

doi:10.1371/journal.pone.0253417

Cited by 15 publications

(18 citation statements)

References 30 publications

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“…This finding is consistent with Rogaczewska et al, who stated that the superficial capillary plexus thickness was significantly lower in the eyes of patients with MS than in the controls. 21 Peripapillary region vessel density reduction in the whole sectors, revealed through OCT-angio, is consistent with Feucht et al, who considered such reduction of blood supply correlated to tissue atrophy with subsequent reduction of their metabolic needs. 10 However, our finding of vessel density reduction in both macula and peripapillary capillary plexus is consistent with Cennamo et al that the RNFL might suffer indirectly from vascular damage to the optic nerve, and the story might start as a vasculopathy ended by nerve fibre layer reduction.…”

Section: Open Accesssupporting

confidence: 88%

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Expression of poly(ADP-ribose) polymerase-1 gene and optical coherence tomography angiographic parameters among patients with multiple sclerosis

et al. 2022

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Back ground/aimsTo analyse different parameters of the macula, disc and their vascular affection using optical coherence tomography (OCT) and angiography (OCT-A) in patients with multiple sclerosis (MS) correlating these changes to PARP-1 gene expression in blood.MethodsThis cross-sectional study included 80 eyes of the clinically diagnosed relapsing-remitting phenotype of MS. The study included three groups; group (A) included 40 eyes of 20 patients with MS with a history of optic neuritis (MS+ON), group (B) included 40 eyes of 20 patients with MS without a history of ON (MS-ON) and group (C) (the control group) consisted of 40 eyes of 20 matched participants not suffering from any ocular or systemic disease. OCT and OCT-A, RTVue (Optovue, Fermont, California, USA) were done for all eyes for evaluating the macular and disc changes. Qualitative real-time PCR for estimation of PARP1 gene expression level was performed for all patients.ResultsPARP-1 gene expression level showed a significant difference in comparing the three groups, with the highest level being for the (ON+) group (p<0.0009). Significant negative correlations were found between PARP-1 gene expression level and central macular thickness, total macular volume and full foveal vessel density thickness. ROC curve constructed by plotting the area under the receiver operating characteristic curve value was (0.9) for PARP-1 gene expression level.ConclusionsPARP-1 may play an important role in the development of the ON cascade in patients with MS and may be a biomarker for diagnosing and a potential molecular target of ON in MS patients’ therapy. In addition to the OCT and OCT-angio changes that could be detected retrospectively, PARP-1 gene expression level could be considered a prospective detector to complete the full-blown picture of MS (ON+) early and prevent blindness.

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Section: Open Accesssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Expression of poly(ADP-ribose) polymerase-1 gene and optical coherence tomography angiographic parameters among patients with multiple sclerosis

et al. 2022

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“…This may suggest layer specific changes in the disease course over time, or regional differences in the retina. Similar differences have also been noted in other diseases using OCTA, such as multiple sclerosis (34). One group provides a possible explanation for layer-specific differences, positing that loss of vasculature in one layer could lead to compensatory angiogenesis in another, thereby increasing vascular density (35).…”

Section: Utility Of Octasupporting

confidence: 58%

OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment

Green

Choi

Ramchandran

et al. 2022

Front. Digit. Health

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The human retina and retinal imaging technologies continue to increasingly gain the attention of schizophrenia researchers. With the same embryologic origin as the brain, the retina offers a window into neurovascular changes that may underlie disease. Recently, two technologies that have already revolutionized the field of ophthalmology, optical coherence tomography (OCT), and a functional extension of this, optical coherence tomography angiography (OCTA), have gained traction. Together, these non-invasive technologies allow for microscopic imaging of both structural and vascular features of the retina. With ease of use and no side effects, these devices are likely to prove powerful digital health tools in the study and treatment of schizophrenia. They may also prove key to discovering disease relevant biomarkers that underly neurodevelopmental and neurodegenerative aspects of conditions such as schizophrenia.

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“…Data on alterations of the DVC in eyes with an ON history are conflicting. Both DVC loss, 7 , 20 DVC thickening, 19 and comparable DVC measures to non-ON eyes 6 , 18 have been described by different groups using different OCT-A devices. Here, vessel measures may vary greatly and cannot be transferred interchangeably between OCT-A devices.…”

Section: Discussionmentioning

confidence: 93%

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

Aly

Noll

Wicklein

et al. 2022

Neurol Neuroimmunol Neuroinflamm

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Background and ObjectivesRarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory relapse including acute optic neuritis (ON) and to search for associations with alterations of the retinal architecture and visual function.MethodsThis prospective longitudinal cohort study included patients with relapsing-remitting MS or clinically isolated syndrome having an acute ON (n = 20) or a non-ON relapse (n = 33). Patients underwent examinations at baseline and after 7, 14, 28, 90, and 180 days with OCT, OCT-A, and assessment of the high- (HCVA) and low-contrast visual acuity (LCVA).ResultsRetinal vessel loss of the superficial vascular complex (SVC) evolves early after ON and reaches a plateau between 90 and 180 days (relative vessel loss 15% ± 8% [mean ± SD]). In addition, an 18% ± 18% intraindividual increase of the foveal avascular zone (FAZ) is evident within 180 days after acute ON. Both SVC thinning and FAZ enlargement were associated with worse HCVA and LCVA. Rarefication of the SVC evolved simultaneously to thinning of the common ganglion cell and inner plexiform layer (GCIP) after ON. No alterations of the deep vascular complex were seen in eyes with ON, and no alterations of the retinal vasculature were recognized in patients having acute non-ON relapses.DiscussionRarefication of the SVC and growing of the FAZ evolve rapidly after ON and are linked to persistent visual disability. ON-related SVC thinning might be closely linked to GCIP atrophy and might occur due to an altered local metabolic activity within inner retinal layers.

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Macular vessel density differs in multiple sclerosis and neuromyelitis optica spectrum disorder: An optical coherence tomography angiography study

Cited by 15 publications

References 30 publications

Expression of poly(ADP-ribose) polymerase-1 gene and optical coherence tomography angiographic parameters among patients with multiple sclerosis

Expression of poly(ADP-ribose) polymerase-1 gene and optical coherence tomography angiographic parameters among patients with multiple sclerosis

OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

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