Maculopapular drug eruption due to the Japanese herbal medicine Kakkonto (kudzu or arrowroot decoction)

Akita, Hirotaka; Sowa, Junko; Makiura, Munehiko; Akamatsu, Hirohiko; Matsunaga, Kayoko

doi:10.1034/j.1600-0536.2003.00151.x

Cited by 7 publications

(6 citation statements)

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“…In our study, two adverse events—drug eruption, fever—were reported. There have been a few reports of drug eruptions with herbal medications containing Paeonia lactiflora Pallas, one of the active ingredients in SGT [ 25 , 26 ]. Although it may have been the cause of the patient's symptom, clinical possibility of SGT causing the fever seems to be low.…”

Section: Discussionmentioning

confidence: 99%

Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy

Lee

Son

Hwang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. Herbal medicine has been widely used to treat drug resistant epilepsy. Shihogyejitang (SGT) has been commonly used to treat epilepsy. We investigated the effect and safety of SGT in children with drug resistant epilepsy. Design. We reviewed medical records of 54 patients with epilepsy, who failed to respond to at least two antiepileptic drugs and have been treated with SGT between April 2006 and June 2014 at the Department of Pediatric Neurology, I-Tomato Hospital, Korea. Effect was measured by the response rate, seizure-free rate, and retention rate at six months. We also checked adverse events, change in antiepileptic drugs use, and the variables related to the outcome. Results. Intent-to-treat analysis showed that, after six months, 44.4% showed a >50% seizure reduction, 24.1% including seizure-free, respectively, and 53.7% remained on SGT. Two adverse events were reported, mild skin rash and fever. Focal seizure type presented significantly more positive responses when compared with other seizure types at six months (p = 0.0284, Fisher's exact test). Conclusion. SGT is an effective treatment with excellent tolerability for drug resistant epilepsy patients. Our data provide evidence that SGT may be used as alternative treatment option when antiepileptic drug does not work in epilepsy children.

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Section: Discussionmentioning

confidence: 99%

Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy

Lee

Son

Hwang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…In areas of northeast Asia such as Korea, China, and Japan, various herb roots are widely used for food and medicine, and a few cases of food allergy induced by the ingestion of herbs, including arrowroot and ginseng, have been reported [4,5]. However, no food allergies to the Chinese bellflower had to date been reported; to the best of our knowledge, this is the first report of anaphylaxis induced through ingesting Chinese bellflower root and its IgE-binding components.…”

Section: Discussionmentioning

confidence: 99%

Chinese Bellflower Root Anaphylaxis: IgE-Binding Components and Cross-Reactivity With Mugwort and Birch

Kim

Lee

Park

et al. 2009

Korean J Intern Med

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A 56-year-old man who had suffered from seasonal rhinitis in spring and autumn experienced recurrent generalized urticaria and an oral burning sensation after eating several cooked herbs for 3 months. A skin-prick test showed positive responses to various pollens, celery, Chinese bellflower, and arrowroot. The Chinese bellflower-specific IgE ELISA OD value was 1.547. Oral challenge with unprocessed raw Chinese bellflower root provoked oral burning sensation, eyelid swelling, generalized urticaria, and hypotension. In an ELISA inhibition test, IgE binding to Chinese bellflower was significantly inhibited by Chinese bellflower, mugwort, and birch pollen extract. SDS-PAGE and immunoblot assay revealed nine IgE-binding components, and common protein bands were detected in the range of 40~55 kDa (Chinese bellflower-mugwort-birch) and 14 kDa (Chinese bellflower-birch). Chinese bellflower root can cause anaphylaxis and may have cross-reactivity with mugwort and birch.

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“…A case of maculopapular exanthema due to arrowroot ingestion was reported and confirmed by a patch test, suggesting type IV hypersensitivity. 2 Two cases of toxic hepatitis associated with arrowroot ingestion have been reported in which generalized urticaria was accompanied by hepatitis. 5 In this case, the patient showed only generalized urticaria without any other organ involvement, suggesting an IgE-mediated reaction.…”

Section: A Case Of Generalized Urticaria Caused By Arrowroot Ingestionmentioning

confidence: 99%

“…Allergic reactions to arrowroot have rarely been reported, and immunologic investigations have not yet been performed. 2 We report a case of generalized urticaria induced by ingestion of fresh arrowroot.…”

Section: A Case Of Generalized Urticaria Caused By Arrowroot Ingestionmentioning

confidence: 99%

“…1 The gerbil (Meriones unguiculatus) is a popular pet that is also used as an animal model for immunology studies. 2 Cases of allergy to gerbils have rarely been reported, and gerbil allergens have not been characterized to date. 3,4 A 33-year-old female biologist and smoker with pollinosis who worked with guinea pigs and gerbils was treated at Fundación Jiménez Díaz.…”

Section: Occupational Asthma Caused By Gerbil: Purification and Partimentioning

confidence: 99%

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