Madecassoside and Asiaticoside-Loaded Film-Forming Polymeric Solutions Based on Hypromellose E5 and Eudragit® NE 30D

Abstract

The aim of this work was to prepare and evaluate the physicochemical properties of film-forming polymeric solutions containing madecassoside and asiaticoside. The stability and in vitro release were also investigated. Hypromellose E5 and Eudragit® NE 30D were used as film-forming agents. Glycerin was used as a plasticizer. Ethanol is used as a solvent and for shortening film drying. The best formulations composed of 5 % hypromellose E5, glycerin, ethanol, and Centella asiatica Cosmélène® in the ratio of 60:20:20:10 (Formulation 11) or 60:20:10:10 (Formulation 12) w/w. It could form a complete film after being applied to the skin within 10 - 15 min. The pH, viscosity, and spreadability values were 7.9, 23.7 cP, 25.1 g·cm2/s, for Formulation 11, and 7.9, 27.1 cP, and 23.4 g·cm2/s, for Formulation 12, respectively. They were stable for at least 6 months. Both formulations released only 13 % of madecassoside and 14 -15 % of asiaticoside to the phosphate buffer pH 7.4. In conclusion, the developed FFPS could be used as the delivery system for madecassoside and asiaticoside for skin application. HIGHLIGHTS The best film-forming polymeric solution formulation composed of 5 % hypromellose E5, glycerin, ethanol, and Centella asiatica Cosmélène® in the mass ratio of 60: 20: 20 (or 10): 10, respectively The developed film-forming polymeric solution was stable for at least six months at various temperatures The low content of madecassoside and asiaticoside released from the formulation was observed GRAPHICAL ABSTRACT