Madelung's disease

Gomez-Antunez, M.; Muiño-Miguez, A.; Julian-Romero, M. San; Lόpez-Berastegui, O.; Lavilla-Olleros, C.; Santos-Martinez, J.; Millán-Nuñez-Cortés, Jesús

doi:10.1016/j.ejim.2013.08.480

Cited by 2 publications

(3 citation statements)

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“…Acomete, geralmente, indivíduos entre 30 e 60 anos de idade. A desordem parece ser mais comum nos países mediterrâneos, com incidência relatada na Itália de um caso para cada 25.000 homens 3,4 .…”

Section: Discussionunclassified

“…No tipo 1, a gordura se acumula predominantemente ao redor do pescoço, na parte superior do dorso e dos ombros, o que confere ao paciente uma aparência "pseudoatlética", mais típico dos homens, conforme observado neste caso. No tipo 2, o tecido adiposo se estende sobre todo o corpo, principalmente em torno dos quadris e das coxas, o que dá ao paciente a impressão do mesmo ser obeso; este quadro costuma ser mais comum nas mulheres 4,5,9 .…”

Section: Introductionunclassified

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Doença de Madelung (lipomatose simétrica múltipla)

Guariento

Gomes

Esteves

et al. 2019

Medicina (Ribeirao Preto Online)

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Modelo do estudo: O presente estudo é um relato de caso, realizado a partir de revisão de prontuário, autorizado pelo comitê de ética do hospital, e o termo de consentimento livre e esclarecido assinado pelo paciente. Importância do problema: A doença de Madelung ou lipomatose simétrica múltipla é uma desordem rara, de etiologia indefinida, associado frequentemente ao alcoolismo e caracterizada pela presença de massas de tecido adiposo, não encapsuladas, distribuídas simetricamente, principalmente nas regiões superiores do tronco e cervical, que aumentam progressivamente de tamanho e levam a desfiguração cosmética do paciente. Pode provocar sintomas derivados de compressão de estruturas vasculares, nervosas e do trato aerodigestivo. A lipectomia e lipoaspiração são os tratamentos de escolha, embora geralmente paliativo. Comentários: O presente trabalho relata um caso da doença de Madelung e apresenta uma breve revisão da literatura sobre o tema, ressaltando-se a importância do reconhecimento clínico desta entidade, bem como o seu manejo multidisciplinar.

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Section: Discussionunclassified

Section: Introductionunclassified

Doença de Madelung (lipomatose simétrica múltipla)

Guariento

Gomes

Esteves

et al. 2019

Medicina (Ribeirao Preto Online)

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“…In these patients, alcohol withdrawal and weight loss should be recommended, although this may not prevent the progression of the course of the disease. 8 Informed Consent: Written informed consent was obtained from patient who participated in this case.…”

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Multiple Symmetric Lipomatosis: Madelung’s Disease

Özel¹,

Şibar²,

Özmen³

et al. 2016

Turk J Plast Surg

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Dear Editor, Multiple symmetric lipomatosis (MSL), known as Madelung's disease, is characterized by the growth of uncapsulated masses of adipose tissue. 1 These abnormal diffuse lipomas grow in different areas of the body, generally in the neck, shoulder, and inguinal areas. 2 MSL typically occurs around the neck (buffalo humps), parotid region (hamster cheeks), and cervical region (horse collar). 3 The problem is almost entirely cosmetic, but functional problems have been occasionally reported, such as tracheal compression 4 , difficulty in obtaining clothes that fit, and inability to turn the head from side to side. 5 A 52-year-old woman presented to our department complaining of severe neck and back pain and presented with an 11-year history of progressively growing fatty masses in the neck, shoulder, chest, and back regions (Figures 1-3). She had undergone 12 previous surgical operations for the correction of this deformity. Liposuction alone had been performed seven times, and dermolipectomy had been performed five times in the neck area; however, the outcome was only minimal compression relief and repeated relapse of progressive growth. Initial biopsies of the adipose mass confirmed the presence of adipose tissue without malignant transformation. The patient is a nonsmoker and has no alcohol intake history. There was no family history of a similar disorder as well. Physical examination showed multiple giant soft tissue masses involving the neck, shoulders, and back. There were transverse cervical scars observed in the neck area. Routine preoperative laboratory tests were normal. Superwet conventional liposuction procedure was performed to the five distinct areas on the back under general anesthesia. A total of 3000 mL was aspirated from these areas. After liposuction, dermolipectomy was performed to remove the fat deposits of the right subscapular region (12×6.5 cm) to excise the redundant skin. A closed suction drain was placed. A compression bandage was applied to the operative area that dissipates the dead space. The drain was removed one day after the surgery. The patient was discharged from the hospital on post-operative day 1. In the early post-operative period, there was a serous fluid leakage from the cannula entry point, but this problem was resolved spontaneously in the following four days. Histological examination revealed normal lipomatous tissue. During the follow-up period, the patient was satisfied with the cosmetic result and the relief from neck and back pain (Figures 4, 5). The patient is in the 1.5 th postoperative month, with only minimal complaints of neck and back pain, but the cosmetic problems still persist. Multiple symmetric lipomatosis is an extremely rare disease, characterized by diffuse, painless, uncapsulated, symmetrical accumulation of fat tissues. 6

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Madelung's disease

Cited by 2 publications

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Doença de Madelung (lipomatose simétrica múltipla)

Doença de Madelung (lipomatose simétrica múltipla)

Multiple Symmetric Lipomatosis: Madelung’s Disease

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