MAGE-A and NY-ESO-1 expression in cervical cancer: Prognostic factors and effects of chemotherapy

Napoletano, Chiara; Bellati, Filippo; Tarquini, Elisabetta; Tomao, Federica; Taurino, Federica; Spagnoli, Giulio C.; Rughetti, Aurelia; Muzii, Ludovico; Nuti, Marianna; Panici, Pierluigi Benedetti

doi:10.1016/j.ajog.2007.05.019

Cited by 44 publications

(28 citation statements)

References 18 publications

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“…However, protein expression has been demonstrated by immunohistochemistry in tissues of cervical cancer patients only for MAGE-A (34%) 7 and NY-ESO-1 (49%). 7 In contrast, SPAG9 mRNA and protein expression was detected in 82% of cervical cancer tissues irrespective of disease stages. This is an important feature that could lead to the identification and characterization of tumor-specific targets for immunotherapy and the development of cancer biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…A unique class of tumor-associated antigens coded by the cancer testis (CT) gene family are being investigated as cancer biomarkers because of their aberrant expression in various types of cancer. 6 In this context, expression of several CT antigens, namely MAGE-A, 7 GAGE, 8 CAGE-1, 9 NY-ESO-1, 7 CRT2, 10 and SSX4, 11 have been reported in cervical cancer. However, humoral and cellular immune responses have been reported for only a few CT antigens.…”

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confidence: 99%

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Sperm‐associated antigen 9 is a biomarker for early cervical carcinoma

Garg

Kanojia

Salhan

et al. 2009

Cancer

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Sperm‐associated antigen 9 is a biomarker for early cervical carcinoma

Garg

Kanojia

Salhan

et al. 2009

Cancer

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“…In some cancers, the expression of CTAs impacts a poorer prognostic future (4)(5)(6)(7)(8). These tissue-restricted proteins can induce spontaneous immune responses when aberrantly produced in tumors as there is no or weak central tolerance against proteins restricted to immunoprivileged sites (9).…”

Section: Introductionmentioning

confidence: 99%

Cancer/testis antigen SSX2 enhances invasiveness in MCF-7 cells by repressing ERα signaling

et al. 2012

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Abstract. Cancer/testis antigen (CTA) SSX2, which is silent in most normal adult tissues and expressed in various malignant tumors, has been identified for decades. Expression of SSX in tumors has been associated with advanced stages and worse patient prognosis. However, little is known about its role in breast cancer. The SSX2 expression plasmid constructed was stably transfected into the breast cancer cell line MCF-7. The influence of SSX2 on MCF-7 cells was assessed using MTT assay, flow cytometry, transwell invasion assay and in vivo tumorigenicity assay. A comparative proteomic approach was performed to identify and clarify the underlying molecular mechanisms. SSX2 expression was more pronounced in ERα-negative breast cancer cells compared with the positive ones. Overexpression of SSX2 induced cell growth and prompted cell invasion. Both ERα and E-cadherin expression were suppressed in the SSX2 overexpressing MCF-7 cells. Eleven known proteins were identified with significant differential expression. Among these, five were decreased, while other six were increased in the SSX2 overexpressing MCF-7 cells. These results suggested SSX2 may enhance invasiveness in MCF-7 cells both in vivo and in vitro. The regulation of ERα signaling by target proteins of SSX2 may explain the metastatic potential of breast cancer cells.

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“…Furthermore, members of the CT-X antigens in particular are typically associated with advanced cancer with poorer outcomes. [28][29][30][31][32] Two dedicated databases published recently, CTpedia (http://www.cta.lncc.br/index.php) that catalogues the known CTAs 33 and ACTAbase (http://actabase.jhu.edu) that also houses microarray gene expression data in addition, serve as excellent resources for detailed information regarding the CTAs (Parekh et al, in preparation).…”

Section: Cancer/testis Antigens (Ctas)mentioning

confidence: 99%