MAGE Xp-2: A Member of the MAGE Gene Family Isolated from an Expression Library Using Systemic Lupus Erythematosus Sera

Dk, McCurdy; Lq, Tai; Nguyen, Joseph; Wang, Z; Hm, Yang; Udar, Nitin; Naiem, Faramarz; Concannon, Patrick; Ra, Gatti

doi:10.1006/mgme.1997.2639

Cited by 16 publications

(15 citation statements)

References 16 publications

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“…As shown by McCurdy et al (1998) MAGE Xp-2 may be expressed in a case of systemic lupus erythematosus. PAGE-1, a GAGE-like gene belonging to another, structurally unrelated family of tumor/embryo/ adult testis-restricted genes, is expressed in normal prostate, testis, uterus, fallopian tube, and placenta, leading the authors to suggest that PAGE-1 might be involved in sex determination (Brinkmann et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Identification of a New, Unorthodox Member of the MAGE Gene Family

et al. 1999

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Several tumor-associated antigen families, such as MAGE, GAGE/PAGE, PRAME, BAGE, and LAGE/NY-ESO-1, exist. These antigens are of particular interest in tumor immunology, because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells only. We have identified a novel member of the MAGE gene family, MAGED1. Northern hybridization and RT-PCR demonstrated that the expression level of MAGED1 in different normal adult tissues is comparable to that in testis and fetal liver. Thus, MAGED1 does not possess an expression pattern characteristic of previously identified MAGE family genes, suggesting that the biology of the MAGE-family genes is more complex than previously thought. Chromosome mapping linked MAGED1 to marker AFM119xd6 (DXS1039) on chromosome Xp11.23.

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Section: Discussionmentioning

confidence: 99%

Identification of a New, Unorthodox Member of the MAGE Gene Family

et al. 1999

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“…These appear to play key developmental roles in the brain [42,43] – and therefore, might be expected to be highly conserved. The large cluster of human MAGE A genes, centered near Xq28 [25,26], have been found to be highly expressed in tumors of various histological types [26], particularly in melanoma and breast carcinoma cell lines [44]. Proteins coded by these genes are also the targets of autoantibodies from patients with systemic lupus erythematosus, and so may play a role in autoimmune diseases [44].…”

Section: Resultsmentioning

confidence: 99%

“…The large cluster of human MAGE A genes, centered near Xq28 [25,26], have been found to be highly expressed in tumors of various histological types [26], particularly in melanoma and breast carcinoma cell lines [44]. Proteins coded by these genes are also the targets of autoantibodies from patients with systemic lupus erythematosus, and so may play a role in autoimmune diseases [44]. A natural speculation is that proteins important in both autoimmune disease and cancer-recognition might require (or acquire) a nimble evolutionary strategy, analogous to the clustered and rapidly-evolving Major Histocompatibility Complex (MHC) gene family in mammals [45,46] – and in contrast to the MAGE-D1 genes that are involved in early brain development.…”

Section: Resultsmentioning

confidence: 99%

OrthoParaMap: Distinguishing orthologs from paralogs by integrating comparative genome data and gene phylogenies

Cannon

Young

2003

BMC Bioinformatics

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Background: In eukaryotic genomes, most genes are members of gene families. When comparing genes from two species, therefore, most genes in one species will be homologous to multiple genes in the second. This often makes it difficult to distinguish orthologs (separated through speciation) from paralogs (separated by other types of gene duplication). Combining phylogenetic relationships and genomic position in both genomes helps to distinguish between these scenarios. This kind of comparison can also help to describe how gene families have evolved within a single genome that has undergone polyploidy or other large-scale duplications, as in the case of Arabidopsis thalianaand probably most plant genomes.

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“…Given that MAGE-A1 is expressed during wound healing as well as in the joints of patients with juvenile arthritis, MAGE-A1 may have a role in inflammation [180, 181]. Furthermore, MAGE-B2 was originally identified as being expressed in patients with systemic lupus erythematosus where MAGE-B2 auto-antibodies can be found [182, 183]. Thus, additional investigation of roles for type I MAGE CTAs in other disease contexts besides cancer is warranted in the future.…”

Section: Transcriptional Regulationmentioning

confidence: 99%

A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases

Lee

Potts

2017

Journal of Molecular Biology

108

118

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Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A subset of MAGEs initially garnered interest as cancer biomarkers and immunotherapeutic targets due to their antigenic properties and unique expression pattern that is primary restricted to germ cells and aberrantly re-activated in various cancers. However, further investigation revealed that MAGEs not only drive tumorigenesis, but also regulate pathways essential for diverse cellular and developmental processes. Therefore, MAGEs are implicated in a broad range of diseases including neurodevelopmental, renal, and lung disorders, as well as cancer. Recent biochemical and biophysical studies indicate that MAGEs assemble with E3 RING ubiquitin ligases to form MAGE-RING ligases (MRLs) and act as regulators of ubiquitination by modulating ligase activity, substrate specification, and subcellular localization. Here, we present a comprehensive guide to MAGEs highlighting the molecular mechanisms of MRLs, their physiological roles in germ cell and neural development, oncogenic functions in cancer, and potential as therapeutic targets in disease.

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MAGE Xp-2: A Member of the MAGE Gene Family Isolated from an Expression Library Using Systemic Lupus Erythematosus Sera

Cited by 16 publications

References 16 publications

Identification of a New, Unorthodox Member of the MAGE Gene Family

Identification of a New, Unorthodox Member of the MAGE Gene Family

OrthoParaMap: Distinguishing orthologs from paralogs by integrating comparative genome data and gene phylogenies

A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases

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