Maggot debridement therapy: A practical review

Jordan, Ashley; Khiyani, Neeraj; Bowers, Steven; Lukaszczyk, John J.; Stawicki, Stanislaw P.

doi:10.4103/ijam.ijam_6_18

Cited by 15 publications

(1 citation statement)

References 74 publications

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“…3 In the United States, one diabetic ulcer can cost up to $10,000 for treatment and an additional $12,000 for a nonhealing ulcer further requiring amputation. 4 In 2019, The Society for Clinical Vascular Surgery reported the mean of care per diabetic foot ulcer from initial presentation to complete wound healing was $24,226 AE $2176. 5 This included $41,420 AE $3318 for inpatient admissions and $11,265 AE $1038 for outpatient procedures.…”

Section: Introductionmentioning

confidence: 99%

Reappraisal and updated review of maggot debridement therapy in chronic lower extremity ulcers

Shamloul

Khachemoune

2023

Int J Dermatology

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Background Dating back to the mid‐1500s, maggot debridement therapy (MDT) has been a viable treatment modality for chronic wounds. In early 2004, the sterile larvae of Lucilia sericata received FDA approval for medical marketing for neuropathic, venous, and pressure ulcers, traumatic or surgical wounds, and nonhealing wounds that have not responded to standard care. However, it currently remains an under‐utilized therapy. The proven efficacy of MDT begs the question if this treatment modality should be considered as a first‐line option for all or a subset of chronic lower extremity ulcers. Objective This article aims to address the history, production, and evidence of MDT and discuss future considerations for maggot therapy in the healthcare field. Methods A literature search using the PubMed database was conducted using keywords, such as wound debridement, maggot therapy, diabetic ulcers, venous ulcers, among others. Results MDT reduced short‐term morbidity in non‐ambulatory patients with neuroischemic diabetic ulcers and comorbidity with peripheral vascular disease. Larval therapy was associated with statistically significant bioburden reductions against both Staphylococcus aureus and Pseudomonas aeruginosa. Faster time to debridement was achieved when chronic venous or mixed venous and arterial ulcers were treated with maggot therapy versus hydrogels. Conclusions The literature supports the use of MDT in decreasing the significant costs of treating chronic lower extremity ulcers, with emphasis on those of diabetic origin. Additional studies with global standards for reporting outcomes are necessary to substantiate our results.

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Section: Introductionmentioning

confidence: 99%